Home-stay get rapid rising in recent years as new tourist accommodation forms of home-stay facility, with its uniqueness, experience, cultural and involvement was welcomed by the masses of tourists.But the development can’t leave the advantage of home-stay facility location,the distribution of home-stay must follow the law of spatial layout, fully considering the influencing factors of layout, location can obtain the best possible yields. Taking Yangshuo county as an example, to study the spatial layout of the home-stay facility, through on-the-spot investigation and ctrip data analysis, Yangshuo home-stay facility mainly distributed in The West Street, Ten-mile Gallery, Yulong River, The Xingping Town and other key tourist development area, and the natural environment, scenic area distribution, transportation, gathering, become the main factors which influence the Yangshuo home-stay facility layout.