Regional cooperation is needed by close geographical location at rnost extent. Although the regions without close geographical location can be cooperated, the cooperation is processed between enterprises not between govemments. Because Chongqing has close geographical relation with regions at upper reaches of Yangtze River and has long cooperation history, the govemment has the un- replaced responsibili-ty for promoting regional cooperation optimization. Central govemment plays an important role in the cooperation but local govemments play more active role in the cooperation.