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As society becomes increasingly dependent upon technology, and so increasingly a subject of public policy scrutiny, it is essential to acquire as much knowledge as possible about technology development, adoption, use, and impacts. The authors propose in detail a long-term study of electronic funds transfer that would cover six major topics: how technology emerges; how new technology is handled by existing institutions; how new technologies are assimilated by the public; what specific impacts new technologies have; how new technologies create synergistic impacts with other technologies; and how technologies change over time to conform to new circumstances and developments. They conclude with a consideration of the measures necessary for the implementation of such a study.  相似文献   
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‘Financial statecraft’, or the intentional use of credit, investment and currency levers by the incumbent governments of creditor – and sometimes debtor – states for both international economic and political advantage, has a long history, ranging from money doctors to currency wars. A neorealist, zero-sum framing of international monetary relations is not inevitable, yet casts a persistent shadow especially during periods of prospective interstate power transitions when previously peripheral countries find themselves with unexpected new capabilities. This article seeks to understand and theorise the financial statecraft of emerging economies, moving beyond the traditional understanding that closely identifies the concept with financial sanctions imposed by a strong state on a weaker state. We propose that the aims of financial statecraft may be either ‘defensive' or ‘offensive’. Financial statecraft may be targeted either ‘bilaterally' or ‘systemically’. Finally such statecraft may employ instruments that are either ‘financial' or ‘monetary’. As emerging market economies have moved up in the ranks in the interstate distribution of capabilities, they have also expanded their financial statecraft strategies from narrowly defensive and bilateral to those involving offensive tactics and targeted at the global and systemic level. Historical and contemporary examples illustrate the analysis.  相似文献   
87.
Objective:

To develop a decision-analytic model to estimate the cost-effectiveness of initiating maintenance treatment with aripiprazole once-monthly (AOM) vs paliperidone long-acting injectable (PLAI) once-monthly among patients with schizophrenia in the US.

Methods:

A decision-analytic model was developed to evaluate a hypothetical cohort of patients initiating maintenance treatment with AOM or PLAI. Rates of relapse, adverse events (AEs), and direct medical costs were estimated for 1 year. Patients either remained on initial treatment or discontinued treatment due to lack of efficacy, AEs, or other reasons, including non-adherence. Data from placebo-controlled pivotal trials and product prescribing information (PI) were used to estimate treatment efficacy and AEs. Analyses were performed assuming dosing of clinical trials, real-world practice, PIs, and highest therapeutic dose available, because of variation in practice settings. The main outcome of interest was incremental cost per schizophrenia hospitalization averted with AOM vs PLAI.

Results:

Based on placebo-controlled pivotal trials’ dosing, AOM improved clinical outcomes by reducing schizophrenia relapses vs PLAI (0.181 vs 0.277 per person per year [pppy]) at an additional cost of US$1276 pppy, resulting in an incremental cost-effectiveness ratio (ICER) of US$13,280/relapse averted. When PI dosing was assumed, this ICER increased to US$19,968/relapse averted. When real-world dosing and highest available dosing were assumed, AOM was associated with fewer relapses and lower overall treatment costs vs PLAI.

Conclusions:

AOM consistently provided favorable clinical benefits. Under various dosing scenarios, AOM results indicated fewer relapses at lower overall costs or a reasonable cost-effectiveness threshold (i.e., less than the cost of a hospitalization relapse) vs PLAI. Given the heterogeneous nature of schizophrenia and variability in treatment response, health plans may consider open access for treatments like AOM. Since model inputs were based on data from separate placebo-controlled trials, generalization of results to the real-world setting is limited.  相似文献   

88.
We examine a set of potentially climate smart agricultural practices, including reduced tillage, crop rotation and legume intercropping, combined with the use of improved seeds and inorganic fertiliser, for their effects on maize yields in Zambia. We use panel data from the Rural Incomes and Livelihoods Surveys merged with a novel set of climatic variables based on geo‐referenced historical rainfall and temperature data to explore the changing effects of these practices with climatic conditions. We estimate the impacts on maize yields, and also on the exhibition of very low yields and yield shortfalls from average levels, as indicators of resilience, while controlling for household characteristics. We find that minimum soil disturbance and crop rotation have no significant impact on these yield outcomes, but that legume intercropping significantly increases yields and reduces the probability of low yields even under critical weather stress during the growing season. We also find that the average positive impacts of modern input use (seeds and fertilisers) are significantly conditioned by climatic variables. Timely access to fertiliser emerges as one of the most robust determinants of yields and their resilience. These results have policy implications for targeted interventions to improve the productivity and the resilience of smallholder agriculture in Zambia in the face of climate change.  相似文献   
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Pacific Asia is deep rooted in its cultural heritage and historical background, which have set the tone for regions success. These same factors also have created rather different trading practices, compared with those of the West — practices that are less transparent and full of hidden private trade barriers.
Interdependence within the region suggests integration, but Pacific Asia has taken a course of non-exclusive cooperation rather than following the exclusive course of the European Community (EC) and of the North American Free Trade Agreement (NAFTA). The latter two trade blocs threaten the continued success and development of Pacific Asia. Although the Uruguay Round of the General Agreement on Tariffs and Trade (GATT) sends relief, fostering a cooperative rather than a retaliative Asian Pacific Economic Cooperation (APEC) organization offers the most promise.  相似文献   
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