Health resource use and costs of vilazodone and other selective serotonin re-uptake inhibitors in treating major depressive disorder

Abstract

Objective:

Selective serotonin re-uptake inhibitors (SSRIs) are widely prescribed antidepressants. This claims database study compared healthcare resource use and costs among patients with major depressive disorder (MDD) treated with vilazodone vs other SSRIs.     

绿色阻垢剂环氧琥珀酸聚合物的研究进展

随着人类环保意识的不断提高,绿色高效阻垢剂的合成与应用是水处理领域研究的发展趋势.阐述了绿色阻垢剂聚环氧琥珀酸及环氧琥珀酸共聚物的研究现状与阻垢机理,针对聚环氧琥珀酸在阻垢性能方面存在的问题,展望了环氧琥珀酸共聚物的研究前景.     

MMP-2、TIMP-2与大肠癌浸润转移关系的研究进展

基质金属蛋白酶-2能有效降解Ⅳ、V型胶原及层粘连蛋白,但它的活性却受到组织金属蛋白酶抑制剂-2的影响。研究证实细胞外基质中基质金属蛋白酶及其组织抑制剂的失衡与多种病理机制有关,尤其是肿瘤的浸润与转移密切相关。本文就基质金属蛋白酶及其组织抑制剂的一般特性、在肿瘤发生和发展中的作用进行了综述。     

聚硅硫酸铝缓蚀性能的研究

该文重点研究了聚硅硫酸铝的缓蚀性能,采用旋转挂片失重法考察了聚硅硫酸铝聚合分子量、用量及pH值对其缓蚀性能的影响,对聚硅硫酸铝和与Zn2+的协同作用进行了分析。研究结果表明,当聚硅硫酸铝聚合分子量在6.6×105左右,投加量0.1mL/L时缓蚀率可达54.2%,和Zn2+复配后最佳缓蚀率可达77.6%,两者协同缓蚀作用很好。     

生物除磷机理与数学模型的探讨

概述了生物除磷在厌氧、缺氧和好氧条件下的反应机理,并基于对反硝化聚磷菌的认识将现有除磷数学模型发展划分为两个阶段。基于除磷数学模拟所包含的涉磷组分、计量学参数、动力学参数以及生物衰减理论等对两阶段模型进行了较为详细的介绍和比较,认为Delft模型是现有模型中比较完善的,并提出今后发展除磷数学模型应重点解决的问题。     

孤东KD641块腐蚀原因及防治措施研究

针对孤东KD641区块出现的腐蚀问题,开展了腐蚀原因分析,通过对不同腐蚀因素开展实验研究找出了该区块的腐蚀原因。同时针对腐蚀因素研制了缓蚀剂,现场试验2口井,结果表明:影响该区块的腐蚀因素主要有氯离子、溶解氧、二氧化碳和细菌4种腐蚀因素。针对这些因素开发了缓蚀剂,现场应用后,可使腐蚀速率由原来的0.242 3mm/a下降到0.034 7mm/a,见到了良好的防腐效果。     

The economic burden of switching targeted disease-modifying anti-rheumatic drugs among rheumatoid arthritis patients

Aims: To estimate real world healthcare costs and resource utilization of rheumatoid arthritis (RA) patients associated with targeted disease modifying anti-rheumatic drugs (tDMARD) switching in general and switching to abatacept specifically.

Materials and methods: RA patients initiating a tDMARD were identified in IMS PharMetrics Plus health insurance claims data (2010–2016), and outcomes measured included monthly healthcare costs per patient (all-cause, RA-related) and resource utilization (inpatient stays, outpatient visits, emergency department [ED] visits). Generalized linear models were used to assess (i) average monthly costs per patient associated with tDMARD switching, and (ii) among switchers only, costs of switching to abatacept vs tumor necrosis factor inhibitors (TNFi) or other non-TNFi. Negative binomial regressions were used to determine incident rate ratios of resource utilization associated with switching to abatacept.

Results: Among 11,856 RA patients who initiated a tDMARD, 2,708 switched tDMARDs once and 814 switched twice (to a third tDMARD). Adjusted average monthly costs were higher among patients who switched to a second tDMARD vs non-switchers (all-cause: $4,785 vs $3,491, p?p?p?p?=?.021), and numerically lower all-cause costs ($4,444 vs $4,741, p?=?0.188). Switchers to TNFi relative to abatacept had more frequent inpatient stays after switch (incidence rate ratio (IRR) = 1.85, p?=?.031), and numerically higher ED visits (IRR = 1.32, p?=?.093). Outpatient visits were less frequent for TNFi switchers (IRR = 0.83, p?Limitations and conclusions: Switching to another tDMARD was associated with higher healthcare costs. Switching to abatacept, however, was associated with lower RA-related costs, fewer inpatient stays, but more frequent outpatient visits compared to switching to a TNFi.     

相控阵雷达T/R组件的效费比随机petri网维修模型

针对T/R组件在备件库存、保障模式以及维修策略方面的特点,建立了两级维修保障体制下相控阵雷达的效费比随机Petri网模型。首先对随机Petri网性能存在的不足进行分析,并对其进行改进,引入抑制弧和全局时间,建立了多部件条件下不同连接方式的系统Petri网模型;其次以多部件当中的k/N系统连接方式为基础,建立了相控阵雷达系统的Petri网模型并进行实例验证;最后对模型中的使用可用度和单位时间维修费用进行分析。实例仿真表明,该Petri网模型可信度高,可以分析基层级和基地级初始备件数量、维修策略参数(m,NG)对系统保障效能的影响,克服了传统解析方法建模的局限,更加贴合实际。     

龋齿菌繁殖抑制剂

龋齿菌繁殖抑制剂含有γ—癸内酯、γ—十一内酯一种或两种化合物。     

催化裂化油浆结垢原因及解决措施

讨论了催化裂化油浆系统的结垢原因及减少其结垢的措施。介绍了近年来国内外催化裂化油浆的发展状况和应用效果。针对我国的实际情况提出了一些设想和建议。