我国药物安全性评价及GLP的有效实施

我国新药在上市前,所进行的新药审批须经非临床与临床研究,其安全性评价尤为重要。新药非临床安全性研究的最终目的就是为了降低临床研究安全性方面的风险性,只有当GLP标准表明该药有充分的安全性和有效性,才可进入临床研究。由于我国医药行业存在诸多问题,多数新药临床前安全性评价不符合GLP标准,不得上市造福人类,药企也面临着无法生存的难题。因此,必须坚持和落实科学发展观,确保新药安全性评价以及GLP的有效实施。     

ARE CONSUMERS MORE LOYAL TO NATIONAL BRANDS THAN TO PRIVATE LABELS?

The evolution of private labels (PLs) can be understood in terms of a strategy adopted by the retail industry with the aim of competing with national brands (NBs). In the 1990s, this strategy led to the development of ‘me too’ products, which currently represent the largest share of store brand products. Since the early 2000s, retailers have widened the range of their store brands by introducing high‐quality products. The aim of this study was to estimate consumers’ attachment to ‘me‐too’ and niche PLs respectively, as compared to NBs. We captured the degree of maturity of these PLs through their price‐elasticities, computed for three staple goods offered by three mass retail companies. It was found that price sensitivity does not differ much between the ‘me‐too’ PLs and the corresponding NBs. This result confirms that ‘me‐too’ products are now considered reliable quality brands. However, in the high quality segment, consumers remain more sensitive to the price of PLs than to that of NBs, a characteristic which may relate to their recent introduction on the market.     

Effects of Network Embeddedness on the Relationship Between Environmental Volatility and Interfirm Contracts

Purpose: This study examines the effects of an embedded network on the contractual relationship between exchange parties under conditions reflecting varying levels of environmental volatility and investigates the role of an important network factor—the embedded network—in the contractual relationship between manufacturers and their suppliers.

Methodology: The empirical test was conducted with manufacturing companies in the context of manufacturer–supplier relationships. Construct measures were based on existing measures and previous research. Measurement reliability and validity were established using exploratory and confirmatory factor analysis and an overall measurement model was assessed with structural equation modeling using LISREL.

Findings: The results of a survey of manufacturers indicate that firms in an embedded network preferred “soft” contracts even when they face volatile environments, whereas those facing volatile environments in a less embedded network preferred “hard” contracts with explicitly specified written requirements. Network partners carefully evaluated embedded networks (a critical factor that has not received enough attention) before forming contractual relationships in a network perceiving interfirm relationships differently.

Originality: The study introduces network embeddedness to explain governance mechanisms in volatile environments and shows that the explicit recognition of embedded network may facilitate the development of contracts with specific provisions as the contractual relationship evolves.     

专用性人力资本投资与饭店业基层员工低薪酬现象成因解释

我国饭店业正逐步演变为典型的低薪酬行业，主要表现为固定工资合约逐渐成为主导性薪酬契约，且固定工资基数水平不断下降。文章运用专用性人力资本理论，解释了在隐性知识管理机制缺失的条件下，饭店业主为什么会放弃对专用性人力资本投资收益的追求而选择固定工资合约，并进一步分析了固定工资合约的实际支付水平为什么会逐步下降，直至最终形成接近法定最低工资标准的全行业统一价格。     

浅析宏观经济政策对金融市场的影响

近几年来,国内经济的发展可谓势头猛增,国家出台了一系列的宏观经济政策,这些宏观经济政策对我国金融市场的发展具有一定的影响。本文就国家的宏观经济政策对我国的金融市场产生的影响进行浅析评论。     

The impacts of international tourism demand on economic growth of small economies dependent on tourism

This paper studies the impacts on economic growth of a small tourism-driven economy caused by an increase in the growth rate of international tourism demand. We present a formal model and empirical evidence. The ingredients of the dynamic model are a large population of intertemporally optimizing agents and an AK technology representing tourism production. The model shows that an increase in the growth of tourism demand leads to transitional dynamics with gradually increasing economic growth and increasing terms of trade. In our empirical application, an econometric methodology is applied to annual data of Antigua and Barbuda from 1970 to 2008. We perform a cointegration analysis to look for the existence of a long-run relationship among variables of economic growth, international tourism earnings and the real exchange rate. The exercise confirms the theoretical findings.     

工民建混凝土施工的质量控制措施

在建筑行业中,混凝土因为其价格低廉、抗压强度高和容易成型等优势条件,成为了建筑行业最广泛的材料。但是由于施工过程中操作不当或者浇筑条件控制不严格等原因,会经常引起各种质量事故。混凝土质量高低是工民建施工质量控制的关键,在本文中,笔者对工民建混凝土施工的质量控制措施进行了分析和研究。     

基于古诺模型的四种市场的社会福利

市场根据垄断程度的不同。可以分为完全竞争、垄断竞争、寡头垄断和完全垄断市场四种类型。基于古诺模型，用博弈论方法研究n个厂商市场情形的总产量、价格、总收益和消费者剩余并把它们归纳为统一的公式。从四种市场情形总产量和价格的特点推出其供给曲线的形状，进而比较其社会福利的状况。研究结果表明，随着垄断性的加强，市场的社会福利会越来越劣，完全竞争市场的社会福利最好，垄断竞争市场次之，寡头垄断市场更次，完全垄断市场的社会福利最差。     

我国居民消费增长的未来趋势与现实抑制

经济增速维持高位、就业形势趋好、收入分配格局改善等利好因素支撑着我国居民消费的长期增长趋势。但是,消费率偏低仍然是困扰我国经济发展方式转变的主要困难。收入分配差距大、公共服务不健全、消费环境不佳、通货膨胀、外部不确定性等矛盾同时制约着消费增长。必须长期制度创新与短期政策优化相结合,力促居民消费增长。     

基于激励的IT企业员工需求特征分析

本文以奥尔德弗的生存、关系、成长需求理论的基本观点为基础,得出针对IT企业员工的主要工作激励因素,从工作激励因素角度对IT企业员工的需求特征进行分析。在此基础上,提出IT企业员工工作激励因素调查问卷,采用聚类分析方法,对成都市某IT企业的员工进行实证研究。