我国细胞治疗产业发展现状研究

中国在细胞治疗领域的基础研究位列世界前列,一些龙头企业正在积极进行相关技术的研发,加紧全产业链的布局,我国的细胞治疗产业正处于成功商业化和临床受益的爆发点。介绍了我国细胞治疗的市场环境、政策环境、国内外最新研究进展和我国细胞治疗行业代表企业的发展情况,提出了未来我国发展细胞治疗产业的关键挑战,并对今后的发展方向进行了展望。     

The cost-effectiveness of alectinib in anaplastic lymphoma kinase-positive (ALK+) advanced NSCLC previously treated with crizotinib

Introduction Anaplastic lymphoma kinase (ALK) targeting drugs provide an important option for advanced non-small cell lung cancer patients with this distinct tumor type; however, there is considerable uncertainty as to which drug provides the optimal value after crizotinib treatment. This study estimated the cost-utility of alectinib vs ceritinib from a US payer perspective.

Methods A cost-utility model was developed using partition survival methods and three health states: progression-free (PF), post-progression (PP), and death. Survival data were derived from the key clinical trials (alectinib: NP28761 &; NP28673, ceritinib: ASCEND I and II). Costs included drugs, adverse events, and supportive care. Utilities were based on trial data and the literature. One-way and probabilistic sensitivity analyses (PSA) were performed to assess parameter uncertainty.

Results Treatment with alectinib vs ceritinib resulted in increases of 2.55 months in the PF state, 0.44 quality adjusted life-years (QALYs), and $13,868, yielding a mean cost/QALY of $31,180. In the PSA, alectinib had a 96% probability of being cost-effective at a willingness-to-pay of $100,000/QALY. Drivers of model results were drug costs and utilities in the PF health state. The ICER ranged from $10,600–$65,000 per QALY in scenario analyses, including a sub-group analysis limited to patients with prior chemotherapy and crizotinib treatment.

Conclusions Treatment with alectinib in ALK?+?crizotinib-treated patients increased time progression-free and QALYs vs ceritinib. The marginal cost increase was driven by longer treatment durations with alectinib. This model demonstrates that alectinib may be considered a cost-effective treatment after progression on crizotinib.     

On regulations for 5G: Micro licensing for locally operated networks

Future 5G networks aim at providing new high-quality wireless services to meet stringent and case-specific needs of various vertical sectors beyond traditional mobile broadband offerings. 5G is expected to disrupt the mobile communication business ecosystem and open the market to drastically new sharing based network operational models. 5G technical features of network slicing and small cell deployments in higher carrier frequencies will lower the investment barrier for new entrants to deploy local radio access networks and offer vertical specific services in specific areas and allow them lease the remaining required infrastructure on demand from mobile network operators (MNO) or infrastructure vendors. To realize the full vision of 5G to benefit the society and promote competition, innovation and emergence of new services when the 5G end-to-end network spans across different stakeholders administrative domains, the existing regulations governing the mobile communication business ecosystem are being refined. This paper provides a tutorial overview on how 5G innovations impact mobile communications and reviews the regulatory elements relevant to 5G development for locally deployed networks. This paper expands the recent micro licensing model for local spectrum authorization in future 5G systems and provides guidelines for the development of the key micro licensing elements. This local micro licensing model can open the mobile market by allowing different stakeholders to deploy local small cell networks with locally issued spectrum licenses ensuring pre-defined quality guarantees for the vertical sectors’ case specific needs.     

要素集聚、产权完整性与城乡收入差距

本文从要素集聚与产权完整性视角研究中国城乡收入差距,认为中国的市场化进程其实就是生产要素从农村地区向城市地区单向流动的过程,并且中国城市居民的产权是完整的,而农村居民的产权是不完整的。这种生产要素的集聚导致城乡交易成本、生产效率的差异,进而导致城乡收入差距;要素集聚还使得城市居民的资产增殖,而农村居民的资产无法增殖;城乡居民产权的完整性差异是生产要素向城市集聚的一个重要原因,通过要素集聚间接影响城乡收入差距;另外城乡居民产权的完整性差异还会直接导致城乡收入差距。本文通过2002—2011年省级面板数据对要素集聚与产权完整性对城乡收入差距的影响予以实证研究,并给出政策建议。     

Aid Quality and Donor Rankings

This paper offers new measures of aid quality covering 38 bilateral and multilateral donors, as well as new insights about the robustness and usefulness of such measures. The 2005 Paris Declaration on Aid Effectiveness and the follow-up 2008 Accra Agenda for Action have focused attention on common donor practices that reduce the development impact of aid. Using 18 underlying indicators that capture these practices—derived from the OECD-DAC’s Survey for Monitoring the Paris Declaration, the new AidData database, and the DAC aid tables—the authors construct an overall aid quality index and four coherently defined sub-indexes on aid selectivity, alignment, harmonization, and specialization. Compared with earlier indicators used in donor rankings, this indicator set is more comprehensive and representative of the range of donor practices addressed in the Paris Declaration, improving the validity, reliability, and robustness of rankings. One of the innovations is to increase the validity of the aid quality indicators by adjusting for recipient characteristics, donor aid volumes, and other factors. Despite these improvements in data and methodology, the authors caution against overinterpretation of overall indexes such as these. Alternative plausible assumptions regarding weights or the inclusion of additional indicators can still produce marked shifts in the ranking of some donors, so that small differences in overall rankings are not meaningful. Moreover, because the performance of some donors varies considerably across the four sub-indexes, these sub-indexes may be more useful than the overall index in identifying donors’ relative strengths and weaknesses.     

结核分枝杆菌诱导抗原提呈细胞Toll样受体表达差异性研究进展

该文结核分枝杆菌感染后,抗原提呈细胞表面Toll样受体(toll-like receptors,TLR)表达差异、抗原提呈细胞的增殖、分化以及相关信号通路作一阐述.     

现代生物技术在食品领域中的应用研究

现代生物学和分子生物学的发展,对基因工程、细胞工程、酶工程、发酵工程等现代生物技术工程产生重要影响,其在食品发酵生产中的应用越来越广。本文阐述了基因工程、细胞工程、酶工程等现代生物技术在食品发酵业的应用。     

马克思剩余价值理论视角下信息商品增值研究

信息劳动创造价值,如何在马克思剩余价值理论视角下研究信息商品增值是一个新的研究课题。信息劳动是复杂劳动,创建期投入巨大,一些信息商品具有独特形式。将信息生产的不同时期的区分引入复杂的劳动过程和价值增殖的研究：信息商品创建期和扩大生产期都属于生产过程,在生产中获得价值增殖的潜力,而通过流通过程,创造出巨大数量的消费受众,从而实现了剩余价值的获得。巨大的规模投资、极高的技术门槛和政府政策保护使信息企业获得超额剩余价值。     

生物气固体氧化物燃料电池研究进展

对近年来国内外生物气固体氧化物燃料电池发电领域的研究进行了归纳分析。在介绍生物气产生和氧离子型固体氧化物燃料电池产电原理的基础上，总结了固体氧化物燃料电池以生物质产出的生物气为燃料发电所涉及的电化学反应；介绍了国外研究者对该类发电过程进行的试验和模拟研究；同时，对生物气结合固体氧化物燃料电池的研究进展进行了分析。得出的结论为，生物气结合固体氧化物燃料电池进行产电具有重大的实际和环保意义。