智能凝胶GD-1混堵技术在靖边气田的应用

靖边气田钻井过程中发生井漏,采用常规堵漏技术(桥塞堵漏、水泥浆堵漏)常堵漏不彻底、容易出现井漏反复等井下复杂情况。基于常规堵漏方法,引进智能凝胶GD-1混堵技术在靖边气田南部黄土表层、刘家沟组裂缝地层应用,取得了良好的防漏、堵漏效果:提高了堵漏成功率,减小堵漏反复性,二次堵漏的几率明显降低。     

中国硅胶行业的生产现状和发展探讨

介绍中国硅胶行业技术进展和存在问题，今后应提高硅胶的产品质量，重点开发高附加值的微米级硅胶。     

固相萃取-气相色谱法测定三七中38种农药残留

三七中药材产品经乙腈提取,盐析,采用C18和硅胶固相萃取柱净化后,用气相色谱仪检测38种有机氯、拟除虫菊酯农药残留含量。结果表明:C18和硅胶固相萃取柱净化能够有效除去三七药材中挥发油、有机酸、皂苷等大部分共萃物和干扰组分,获得较好的净化效果;3个不同浓度水平添加回收率在78.6%~120.3%之间,相对标准偏差为0.1%~12.5%;校准曲线线性相关系数均大于0.999。该方法操作简单、快速稳定、除杂效果明显,适用于三七中药材产品中多种农药残留的日常检测工作。     

凝胶柱分离纯化茶多酚中表没食子儿茶素没食子酸酯的工艺优化

目的：探讨一种适合产业化分离纯化茶多酚中表没食子儿茶素没食子酸酯（EGCG）的工艺。方法以葡聚糖凝胶为填料,研究中压柱层析分离 EGCG 的效果。结果茶多酚经脱色、过柱、冻干后得白色粉末状固体物,经高效液相色谱法（HPLC）检测EGCG的纯度达90%以上。结论本工艺经中试验放大验证适合产业化生产。     

我国无机硅化工产品的开发生产及发展建议

文章介绍了我国硅酸钠及其繁衍物、白发黑、硅胶、硅溶胶、层硅的生产和发展概况，提出了硅化工企业应扩大生产规模及发展深加工、高附加值的硅化工系列产品的建议。     

Effects of pension fund freezing on firm performance and risk

This study considers the effect of freezing defined benefit pension funds on shareholder risk and returns. The conditional models used in this study directly assess the effects of a pension fund freeze on returns and on systematic and residual risk. While pension fund freezes do not significantly affect performance or systematic risk, they do significantly reduce short‐term residual risk. Pension fund freezes therefore do not generally present significant financial advantages to shareholders. Only shareholders of firms with pension funds in crisis would benefit from significant systematic risk reductions. Copyright © 2015 ASAC. Published by John Wiley & Sons, Ltd.     

凝胶色谱法考察头孢唑林钠聚合反应

通过模拟不同贮存条件,采用凝胶色谱法对头孢唑林钠的聚合反应进行了研究,证明温度和水分两种因素是控制头孢唑林钠聚合反应的关键因素,并推断头孢唑林钠聚合反应可能为N型聚合反应。     

A cost-effectiveness analysis of levodopa/carbidopa intestinal gel compared to standard care in late stage Parkinson’s disease in the UK

Abstract

Objective:

Evaluation of cost-effectiveness of levodopa/carbidopa intestinal gel (LCIG), compared to standard care (SC) in patients with advanced Parkinson’s disease (aPD) in the UK.

Design:

Markov model to quantify costs and outcomes associated with LCIG versus SC in aPD patients at Hoehn and Yahr (H&Y) stages 3, 4 or 5 experiencing >50% OFF time per day. Time horizon was lifetime, LCIG treatment was assumed to last maximal 5 years after which patients revert to SC. Model comprised 12 aPD health states according to H&Y status and daily time spent in OFF state. Cost analyses are reported from a UK NHS and Personal Social Services perspective. Uncertainties were assessed through one-way sensitivity analyses.

Comparators:

LCIG, providing patients with continuous dopaminergic stimulation to maximise functional ON time during the day and SC, defined as medically determined best available oral medication.

Main outcome measures:

Cost-effectiveness, based on quality adjusted life years gained, presented as an incremental cost-effectiveness ratio.

Results:

Lifetime analysis yields an incremental cost per QALY of £36,024 for LCIG compared to SC (incremental cost £39,644, QALY gain 1.1). Results were sensitive to time on treatment, health state on treatment initiation, and estimates of long term benefit (OWSA results from £32,127 to £66,421 per QALY). Findings must be considered in the context of the study limitations which were mainly due to data availability constraints.

Conclusions:

LCIG is an effective treatment, reducing OFF time and improving quality of life in advanced PD. It provides value for money in levodopa-responsive aPD patients with severe motor fluctuations when no other treatment options are effective or suitable. Given LCIG is an orphan drug, it is reasonable to suggest that it may be considered cost-effective in the UK setting. However, further research is needed to complete current data gaps and increase robustness of the model.     

定氮法检测凝胶采出液中聚合物浓度的研究

为准确测定凝胶调驱井采出液中的聚合物浓度,利用定氮法分别绘制聚合物溶液与聚合物凝胶的标准曲线,结合采出液聚合物浓度检测的物理模拟实验结果,对标准曲线进行优选。随机抽取大庆油田某采油厂凝胶试验区16口采油井,分别利用定氮法与淀粉-碘化镉法检测采出液的聚合物浓度,对检测结果进行误差分析,拟合经验公式。结果表明,该方法对于凝胶采出液中聚合物浓度的检测准确、有效。     

进出口食品中沙门氏菌PFGE分型及耐药研究

目的：研究进出口食品中分离的沙门氏菌（SA）分子型别和耐药情况。方法：用限制性内切酶XbaⅠ酶切SA染色体DNA进行脉冲场凝胶电泳（PFGE）实验,用BioNumerics软件分析菌株之间的相似度。用Vitek 2进行药敏实验,分析SA耐药情况。结果：24株SA分成22个PFGE型。SA2和SA11之间相似度100%,鼠伤寒SA之间的相似度62.1%～90.3%。药敏实验结果显示5株鼠伤寒SA共有4种耐药谱,部分菌株对青霉素类、呋喃类、氨基糖苷类、磺胺类耐药。结论：进出口食品中分离的SA表现出较大的遗传多样性,但部分菌株有相关性。