Michael Thompson's Rubbish Theory explains how the values of objects change and that to understand how we value objects we need to understand ‘rubbish’, that is, objects which hold no value. He explained that most objects lose value after they are created and eventually become rubbish. However, there are some objects that maintain their value, which he calls ‘durables’. His theory explains how some objects move from rubbish to having durable value. When this theory is adapted to illustrate the multiple values attributed to objects at heritage sites, it is possible to explain how heritage tourism can result in conflict at a destination and how durable objects can lose their value, which is not possible according to Thompson. 相似文献
Celecoxib for the treatment of pain resulting from osteoarthritis (OA) was reviewed by the Tandvårds- och läkemedelsförmånsverket–Dental and Pharmaceutical Benefits Board (TLV) in Sweden in late 2010. This study aimed to evaluate the incremental cost-effectiveness ratio (ICER) of celecoxib plus a proton pump inhibitor (PPI) compared to diclofenac plus a PPI in a Swedish setting.
Methods:
The National Institute for Health and Care Excellence (NICE) in the UK developed a health economic model as part of their 2008 assessment of treatments for OA. In this analysis, the model was reconstructed and adapted to a Swedish perspective. Drug costs were updated using the TLV database. Adverse event costs were calculated using the regional price list of Southern Sweden and the standard treatment guidelines from the county council of Stockholm. Costs for treating cardiovascular (CV) events were taken from the Swedish DRG codes and the literature.
Results:
Over a patient’s lifetime treatment with celecoxib plus a PPI was associated with a quality-adjusted life year (QALY) gain of 0.006 per patient when compared to diclofenac plus a PPI. There was an increase in discounted costs of 529kr per patient, which resulted in an incremental cost-effectiveness ratio (ICER) of 82,313kr ($12,141). Sensitivity analysis showed that treatment was more cost effective in patients with an increased risk of bleeding or gastrointestinal (GI) complications.
Conclusions:
The results suggest that celecoxib plus a PPI is a cost effective treatment for OA when compared to diclofenac plus a PPI. Treatment is shown to be more cost effective in Sweden for patients with a high risk of bleeding or GI complications. It was in this population that the TLV gave a positive recommendation. There are known limitations on efficacy in the original NICE model. 相似文献
Despite the well-established theoretical understanding on the benefits of compact cities to the attainment of sustainable transport goals, there has been a worldwide trend of population decentralization in cities. In this paper, an analytical framework, which can be applied to other cities to quantify the potential commuting travel savings and environmental benefits of different job policies in cities having different rates and patterns of population decentralization, is presented. A case study of Hong Kong in the 1992-2002 decade is used to illustrate the analytical framework. The findings suggest that a city’s population patterns did have significant implications on the commuting travel savings from alternative job relocation policies. With a dispersed population pattern, the expected environmental benefits from a job decentralization policy can be very substantial. 相似文献
In the past decade, the maquiladora export industry surpassed both tourism and petroleum products to become the number one source of earned foreign exchange for Mexico. The continued growth of the maquila industry suggests that there may be significant production spillovers into the local environments. Dynamic modeling, using STELLA, provides a framework for quantifying the environmental impacts emanating from the growth of the maquila industry, focusing on wastewater treatment consequences and resulting infrastructural policy considerations. Such detailed modeling of industrial, infrastructural, and ecological linkages has not yet been a feature of research on this region, despite the potential for significant human health ramifications. An environmental model is therefore developed for two focal urban communities, Nogales and Mexicali, facing potential wastewater treatment concerns due to the growth of nearby maquila factories. In the former case, the analysis revealed the inadequacy of the capacity planning for the treatment of effluent; in the latter case, conservative projections reveal that the system upgrades should be able to handle demands through 2020. 相似文献
Many recent economic studies have shown that traditional economic theory applies to nontraditional settings such as religious
organizations. This paper contrasts two labor markets for clergy that result from different denominational polities to examine
the impact of labor market structure on clergy compensation in Protestant denominations. Many Protestant churches operate
autonomously and clergy and congregations negotiate contracts in a free market. However, in a distinct sub-group of Protestant
denominations there is involvement by denominational hierarchy in order to raise the level of clergy compensation and benefits.
Regression analysis using a unique, random sample of US clergy suggests that different labor market structures result in economically
important and statistically significant differences in the distributions of clergy salaries and benefits.