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1.
Entrepreneurs need to act under conditions of uncertainty and resource constraints to bring new, often-unrecognizable products to market and convince an unknown set of stakeholders to support their endeavours. The type of action entrepreneurs take to navigate uncertain entrepreneurial contexts is underspecified. We analysed 48 interviews with entrepreneurs to inductively identify an action-oriented construct we labelled as entrepreneurial hustle – an entrepreneur’s urgent, unorthodox actions that are intended to be useful in addressing immediate challenges and opportunities under conditions of uncertainty. In a follow-up study, we use an experimental vignette approach to assess the impact of an entrepreneur’s hustle on venture stakeholders. Findings suggest that entrepreneurial hustle positively influences stakeholder perceptions of the entrepreneur’s leadership effectiveness and a venture’s legitimacy, mediated by perceptions of the entrepreneur’s ability-based trustworthiness. We conclude that entrepreneurial hustle is a fundamental behaviour that enables entrepreneurs to enrol new venture stakeholders and lead their entrepreneurial efforts.  相似文献   
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Incentive packages are popular tools for economic development. However, development projects are often considered in isolation without an analysis of opportunity costs. In this study, we use an intuitive framework for comparing projects and weigh alternate projects against North Carolina’s film incentive programme. The results indicate that there are substantial differences in the economic impact of the projects we consider in this study. Our results suggest that policy decisions by governments and economic development officials should weigh a potential project against alternative uses in order to optimize the use of incentives.  相似文献   
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ABSTRACT

The Dualistic Model of Passion (DMP) is an emerging framework in social psychology that assesses individuals’ passion for an activity. Although a passion parallels the definition for a serious leisure activity, the DMP further differentiates between a harmonious (HP) versus an obsessive (OP) passion, which are associated with adaptive versus maladaptive outcomes, respectively. Building on recent research in the area of mindfulness and the growing interest in problem video gaming, the present study explores the effect of dispositional mindfulness on reports of HP and OP. An online sample of adult video game users (N = 1,124; 68.95% male) completed assessments of their passion for video gaming as well as their dispositional mindfulness. Results revealed a negative association between dispositional mindfulness and OP for video gaming, but no association between dispositional mindfulness and HP for video gaming. Further, a moderation effect was found such that high dispositional mindfulness appears to protect against internalizing an OP for video gaming. Finally, results from a latent profile generally supported the role dispositional mindfulness plays in reducing the severity of OP for video gaming. The implications for theory and positive video game engagement are discussed.  相似文献   
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Conclusion Two independent tests with a total of 36 large and medium-sized non-southern cities have demonstrated support for a political explanation of the major riots of the 1960s. It is argued that politically interested and motivated segments of the black community were disaffected because of the failure of government to respond to their demands. Their participation turned minor disorders into major uprisings. An alternative hypothesis, that public policy response generates increased expectations and ultimately greater violence, has been rejected. However, the findings rest upon the riot experience of a small number of cities in the 1960s. It seems very unlikely that the public policies of these cities would have much impact on the expectations of their black citizens and thus the rationale of the alternative hypothesis is undermined. The public policies of other governments, at other times, might have more influence on the expectations of their citizens. Additional research would be required to identify circumstances under which public policy response might lead to increased expectations, disaffection, and ultimately greater violence.  相似文献   
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Aims: To determine the cost-effectiveness of treatment sequences of biologic disease-modifying anti-rheumatic drugs or Janus kinase/STAT pathway inhibitors (collectively referred to as bDMARDs) vs conventional DMARDs (cDMARDs) from the US societal perspective for treatment of patients with moderately to severely active rheumatoid arthritis (RA) with inadequate responses to cDMARDs.

Materials and methods: An individual patient simulation model was developed that assesses the impact of treatments on disease based on clinical trial data and real-world evidence. Treatment strategies included sequences starting with etanercept, adalimumab, certolizumab, or abatacept. Each of these treatment strategies was compared with cDMARDs. Incremental cost, incremental quality-adjusted life-years (QALYs), and incremental cost-effectiveness ratios (ICERs) were calculated for each treatment sequence relative to cDMARDs. The cost-effectiveness of each strategy was determined using a US willingness-to-pay (WTP) threshold of $150,000/QALY.

Results: For the base-case scenario, bDMARD treatment sequences were associated with greater treatment benefit (i.e. more QALYs), lower lost productivity costs, and greater treatment-related costs than cDMARDs. The expected ICERs for bDMARD sequences ranged from ~$126,000 to $140,000 per QALY gained, which is below the US-specific WTP. Alternative scenarios examining the effects of homogeneous patients, dose increases, increased costs of hospitalization for severely physically impaired patients, and a lower baseline Health Assessment Questionnaire (HAQ) Disability Index score resulted in similar ICERs.

Conclusions: bDMARD treatment sequences are cost-effective from a US societal perspective.  相似文献   

7.
Devin Fidler 《Futures》2011,43(5):540-544
This paper explores basic theoretical affinities between Foresight and Futures and Strategic Management, arguing that at this point in its development, Foresight can best be understood and deployed as an explicitly managerial discipline.The growth of Foresight and Futures Studies as a discipline has been less robust than the internal logic of the field would predict, potentially indicating an opportunity for theoretical renewal. Foresight is often justified on managerial grounds, with the argument that a discipline is needed to guide decision-making in a technologically aggressive, post-industrial society. Some within Foresight and Futures Studies have argued for the active development of alternatives to these managerial justifications. However, the links between Strategic Management and Futures Studies are robust and the embrace of cross-disciplinary dialogue has proven invigorating in some other disciplines. An evaluation of the goals and logic of Foresight from the standpoint of mainstream Strategic Management gives a novel perspective on the field, highlighting its importance to information processing. Finally, Foresight speaks to well-established normative problems with short-term biases in managerial contexts. For the purposes of this article, the terms “Foresight” and “Futures Studies” are used interchangeably to refer to the general study of futures.  相似文献   
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有些企业正通过分析员工实践与生产率之间的联系,来提高利润水平。整个上一代人力资源高管都渴望着成为企业领导的战略顾问。但是,这对很多人来说,都很困难,因为如何衡量人力资源方法的业务价值实在太难。“培训的投资回报率是多少”?“哪种筛选方法能找出绩效最佳的招聘人选”?  相似文献   
9.
This article systematically examines differences between student and faculty perspectives on quality instruction, using local data for a regional university's college of business matched to RateMyProfessors.com evaluations. Particular attention is focused on gender bias, “hotness,” and “easiness.” In addition to documenting a student bias or preference in favor of male faculty, this article also shows how students and faculty have different views of “easiness” and “hotness.” For this college, students value “easiness” while faculty penalize it; however “hotness” has no measurable effect on faculty in this study.  相似文献   
10.
Aim: Disease-modifying therapies (DMTs) impact the natural history of relapsing forms of multiple sclerosis (RRMS) by reducing annual relapse rates and slowing disability progression. The effect of DMTs on indirect costs has not been consistently explored in cost-effectiveness studies thus far. The value to patients of an emerging DMT, ocrelizumab, was quantified in comparison to subcutaneous interferon beta-1a (IFNβSC) for the prevalent RRMS population with mild-to-moderate disability in the US, based on two Phase 3 trials, OPERA I and OPERA II, of ocrelizumab vs IFNβSC in RRMS.

Materials and methods: A Markov model was developed to compare disability progression as measured by Expanded Disability Status Scale (EDSS) and relapse outcomes over a 30-year horizon for ocrelizumab vs IFNβSC. Direct, indirect, and informal costs (2016?US dollars) and utilities for EDSS health states were obtained from the literature. Hazard ratios for disability progression and relapse rates were estimated from clinical trials. Value was assessed by calculating the net monetary benefit (NMB), defined as the monetary value of discounted quality-adjusted life years (QALYs) minus total costs, where the value of a QALY was $150,000. One-way sensitivity analyses were conducted.

Results: Ocrelizumab was associated with an incremental gain of 0.84 QALYs and cost savings of $287,713 relative to IFNβSC, resulting in an incremental NMB (INMB) of $413,611 per person over 30 years. The INMB increased by $151,763 for those initiating ocrelizumab at EDSS level 1 vs level 4. Influential parameters were QALY value, treatment costs, and disability progression; however, all sensitivity analyses indicated that the INMB for ocrelizumab relative to IFNβSC was ≥$300,000 per person.

Conclusions: Ocrelizumab provides greater value to RRMS patients compared with IFNβSC. Initiating ocrelizumab at lower EDSS levels leads to a greater cumulative value due to slower disability progression, which extends years with higher quality-of-life.  相似文献   
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