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Aims: To examine healthcare resource utilization associated with refractory myasthenia gravis (MG) in England.

Materials and methods: This was a retrospective cohort study of linked data from the Clinical Practice Research Datalink and the Hospital Episode Statistics database collected between 1997 and 2016. Included patients were ≥18?years of age at the index MG diagnosis. Patients with refractory MG were identified using an algorithm based on treatments received. Healthcare resource utilization since the index date was compared between refractory and non-refractory cohorts.

Results: The study included 1149 patients with MG, of whom 66 (5.7%) were refractory. Sex and age at diagnosis did not significantly differ between the refractory and non-refractory cohorts. Rates of healthcare resource utilization per person-year were significantly higher (p?p?Limitations: The algorithm for identifying refractory patients did not include clinical criteria. Also, treatments administered in hospitals or by specialists were not available in the databases.

Conclusions: Patients in England with refractory MG more often visit healthcare providers, are hospitalized and visit an emergency room than patients with non-refractory MG.  相似文献   
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Counterfeits have been a longstanding concern to global brand manufactures. However, recently, a new product category that partly imitates and partly innovates under the term shanzhai has entered into market. Shanzhai products mimic original leading brands through visual or functional similarities and may also provide additional features. Given this new copycat phenomenon, our study for the first time conceptually distinguishes shanzhai products from counterfeits, theoretically compares the values of consumers choosing shanzhai products versus counterfeits, and empirically tests such differences in one integrative model. Specifically, shanzhai buyers value product functional benefits more than counterfeit buyers, while counterfeit buyers value status consumption, yet experience less self‐clarity than shanzhai buyers. Our findings offer important implications for imitative innovation literature as well as for practitioners.  相似文献   
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Supplier development for sustainability is a critical element of sustainable supply chain management and requires extensive multi‐stakeholder collaboration. This article establishes a conceptual four‐stage framework to analyse the collaborative mechanisms of supplier development practices, and presents an exploratory, qualitative analysis to identify the major contributors of sustainable supplier development practices, such as NGOs, industrial associations, consulting firms etc. Based on semi‐structured interviews about 63 organizations from different regions and industries, this article identifies three types of contributor: drivers, facilitators and inspectors. Instead of traditional stakeholder engagement processes, these contributors actively collaborate with buying firms and suppliers to design, implement and evaluate sustainable supplier development programs. The article then provides a matrix to describe the supply chain coverage and supplier performance of supplier development practices, given the absence or positive involvement of facilitators and inspectors. We conclude our study by suggesting future research directions as well as discussing managerial implications. Copyright © 2017 John Wiley & Sons, Ltd and ERP Environment  相似文献   
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This article measures the size and incomes of six major social classes across the industrial revolution using social tables for England and Wales in 1688, 1759, 1798, 1846, and 1867. Lindert and Williamson famously revised these tables, and this article extends their work in three directions. First, servants are removed from middle‐ and upper‐class households in the tables of King, Massie, and Colquhoun and tallied separately. Second, estimates are made for the same tables of the number and incomes of women and children employed in the various occupations, and, third, incomes are broken down into rents, profits, and employment income. These extensions to the tables allow variables to be computed that can be checked against independent estimates as a validation exercise. The tables are retabulated in a standardized set of six social groups to highlight the changing structure of society across the industrial revolution. Gini coefficients are computed from the social tables to measure inequality. These measures confirm that Britain traversed a ‘Kuznets curve’ in this period. Changes in overall inequality are related to the changing fortunes of the major social classes.  相似文献   
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This article develops a posthuman approach to authorship to challenge implied distinctions and superiorities between the social and material worlds, which can detach academics and their writing from societies and ecosystems. By reimagining academic texts that are open for richer interpretation and accessible to diverse audiences, this article offers two main contributions. Firstly, I develop a conceptualisation of the posthuman author as an 'unbounded gatherer', adding to others' attempts to destabilise predominant humanistic ways of writing about managing and organizing that view authors as autonomous agents. Secondly, by developing the idea of 'mediators' as a means to explore how the sociomaterial is implicated in writing, debates about materiality in writing are extended. Through an illustration of posthuman writing, five emergent categories of mediators are analysed, and three textual practices are performed and examined.  相似文献   
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The lack of a validated measure of active–passive union participation and a dearth of research into the relationship between generational cohort and union participation challenge union leaders to develop policies and practices to facilitate union renewal. We address these issues by (a) developing a multidimensional measure of union participation that captures both active and passive components, (b) using structural equation modelling to validate the measure within a nomological framework, and (c) investigating the impact of generational cohort on all paths in our framework. Data from members of a large American union confirm that generational cohort influences how union members participate in their union. The two‐factor measure developed in this study facilitates research into antecedents and outcomes of passive and active union participation. Our findings should also prove useful to unions seeking to increase participation within their membership, academics researching unions and generational cohort, and human resource practitioners operating in unionised environments.  相似文献   
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