贝前列素钠联合大株红景天治疗腔隙性脑梗死患者的临床效果

目的探讨腔隙性脑梗死患者应用贝前列素钠与大株红景天联合治疗的临床疗效及安全性。方法选取2017年6月至2020年5月辽宁省鞍山市中心医院铁东院区收治的60例腔隙性脑梗死患者作为研究对象,按随机数字表法将其分为观察组与对照组,各30例。对照组行口服常规西药(辛伐他汀、尼莫地平、阿司匹林肠溶片)治疗,观察组采用贝前列素钠与大株红景天联合治疗,比较两组患者治疗效果、血液流变学指标和椎基底动脉平均血流速度改善情况。结果对照组和观察组患者治疗有效率比较,差异无统计学意义(P>0.05)。治疗前两组血液流变学指标比较,差异无统计学意义(P>0.05);治疗后,两组纤维蛋白原、血浆黏度、全血低切黏度、全血高切黏度降低,且观察组低于对照组,差异有统计学意义(P<0.05)。治疗前两组左侧椎动脉、右侧椎动脉、基底动脉平均血流速度比较,差异无统计学意义(P>0.05);治疗后,两组左侧椎动脉、右侧椎动脉、基底动脉平均血流速度升高,且观察组高于对照组,差异有统计学意义(P<0.05)。结论应用贝前列素钠与大株红景天联合治疗腔隙性脑梗死患者临床效果显著,可有效改善患者血液流变学和椎基底动脉血流速度。

Evaluation of the Clinical Effect of Beraprost Sodium Combined with Rhodiola in the Treatment of Patients with Lacunar Infarction

Objective To explore the clinical efficacy and safety of beraprost sodium combined with Rhodiola rosea in the treatment of patients with lacunar cerebral infarction. Methods From June 2017 to May 2020, a total 60 patients with lacunar infarction admitted to the Tiedong District, Anshan Central Hospital were selected as the research objects and were divided into a a control group(n=30) and an observation group(n=30) by random number table method. The control group received oral conventional Western medicine(simvastatin, nimodipine, aspirin enteric-coated tablets) for treatment, and the observation group received beraprost sodium combined with rhodiola. The therapeutic effects, the improvement of blood rheology index and average blood flow velocity of vertebrobasilar artery were compared. Results There was no statistically significant difference in the treatment effective rate between the control group and the observation group(P>0.05). Before treatment, there was no significant difference in hemorheology between the 2 groups(P>0.05);after treatment, fibrinogen, plasma viscosity, whole blood low-shear viscosity, whole blood high-shear viscosity in the 2 groups decreased, and the observation group was lower than the control group, the difference was statistically significant(P<0.05). Before treatment, the average blood flow velocity of left vertebral artery, right vertebral artery, and basilar artery were not statistically different between the 2 groups(P>0.05);after treatment, the 2 groups had left vertebral artery, right vertebral artery, and basilar artery average blood flow velocity increased, and the observation group was higher than the control group, the difference was statistically significant(P<0.05). Conclusion The combination of beraprost sodium and rhodiola in the treatment of lacunar cerebral infarction has a significant clinical effect, which can effectively improve the patient’s hemorheology and vertebrobasilar blood flow velocity.