药物创新的突破口：以核酸及其蛋白复合物为靶点的药物

黄震教授全球首创的硒核酸技术一举解决了核酸生物大分子X射线晶体衍射领域中相位角测定这一重大技术瓶颈难题，硒核酸还能在很大程度上帮助核酸及蛋白复合物结晶，提高晶体结构精度．并且能够非常奸地保持大分子结构同形性。有望在这一领域以及新药研发领域带来革命性影响。

Creating Novel Drugs: Targeting Nucleic Acids and Their Protein Complexes

Professor Zhen Huang is the rst to pioneer and innovatively develop Selenium-derivatized Nucleic Acids (SeNA) platform technology for structure determination and function study of nucleic acids and their protein complexes. This creative technology provides a rational solution to the phasing problem that is one of two long-standing bottle-neck problems in nucleic acid X-ray crystallography. At the same time, selenium derivatization can also signi cantly facilitate crystallization of nucleic acids and their p...