| 超重力技术在6-APA生产过程中的应用研究 |
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| 引用本文： | 郝金恒,邹海魁,刘健,马文婵,纪爱民.超重力技术在6-APA生产过程中的应用研究[J].河北工业科技,2013,30(3):156-159. |
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| 作者姓名： | 郝金恒 邹海魁 刘健 马文婵 纪爱民 |
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| 作者单位： | 石药集团中诺药业(石家庄)有限公司;北京化工大学教育部超重力工程研究中心;河北工业大学化工学院 |
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| 基金项目： | 河北省省级省校科技合作开发基金 |
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| 摘 要： | 针对超重力技术在直通法6-APA生产过程中的应用,研究了进料温度、气液比、电机频率、真空度等条件对醋酸丁酯脱除效果的影响。结果表明,超重力技术可以用于脱酯工艺,在保证脱酯液质量的同时,使相关产品收率有所提高。
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| 关 键 词： | 超重力 6-APA 分离 |
Application of high gravity in the production of 6-APA |
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| HAO Jinheng,ZOU Haikui,LIU Jian,MA Wenchan and JI Aimin.Application of high gravity in the production of 6-APA[J].Hebei Journal of Industrial Science & Technology,2013,30(3):156-159. |
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| Authors: | HAO Jinheng ZOU Haikui LIU Jian MA Wenchan and JI Aimin |
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| Institution: | 1(1.Zhongnuo(Shijiazhuang) Pharmaceutical Company Limited,CSPC,Shijiazhuang Hebei 050041,China;2.Research Center for High Gravity Engineering of Education Ministry,Beijing University of Chemical Technology,Beijing 100029,China;3.College of Chemical Engineering,Hebei University of Technology,Tianjin 300130,China) |
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| Abstract: | Appilication that production of one-pot 6-APA carry through high gravity is reporded in this article,the influence of feed temperature,the gas/liquid ratio,the generator frequency and the vacuum on ester desorption effects,The results showed that high gravity can be used in the technique of ester desorption.In the condition of ensuring the quality of ester desorption liquid,the yield of production is increased. |
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| Keywords: | high gravity 6-aminopenicillanic acid(6-APA) separation |
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