| 头孢呋辛酯合成方法研究 |
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| 引用本文： | 张军立,白鹏.头孢呋辛酯合成方法研究[J].河北工业科技,2006,23(6):328-329,363. |
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| 作者姓名： | 张军立 白鹏 |
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| 作者单位： | 1. 天津大学化工学院,天津,300072;华北制药集团倍达有限公司,河北,石家庄,050065
2. 天津大学化工学院,天津,300072 |
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| 摘 要： | 研究了以二甲基甲酰胺(DMF)为溶剂,头孢呋辛酸为原料,碳酸钾(K2CO3)作催化剂,在0℃下滴加1-乙酰氧-1-溴乙烷,高产率合成头孢呋辛酯的实验过程。探讨了催化剂用量、反应物用量、反应溶剂选择、结晶溶剂等对反应的影响,在最佳条件下,头孢呋辛酯的合成摩尔收率超过90%。
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| 关 键 词： | 头孢呋辛酯 催化剂 合成 |
| 文章编号： | 1008-1534(2006)06-0328-02 |
| 修稿时间： | 2006年7月8日 |
Study on the synthesis of cefuroxime axetil |
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| ZHANG Jun-li and BAI Peng.Study on the synthesis of cefuroxime axetil[J].Hebei Journal of Industrial Science & Technology,2006,23(6):328-329,363. |
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| Authors: | ZHANG Jun-li and BAI Peng |
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| Institution: | School of Chemical Engineering,Tianjin University,Tianjin 300072,China;Beta Company Limited,North China Pharmaceutical Group Corporation,Shijiazhuang Hebei 050065,China;School of Chemical Engineering,Tianjin University,Tianjin 300072,China |
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| Abstract: | The paper studied on the synthesis of cefuroxime axetil,using DMF as solvent,cefuroxime acid as raw material and K_2CO_3 as catalyst and dripping 1-acetoxyethyl bromide at 0 ℃.The effects of the amount of catalyst,the ratio of the reactants,the choice of the solvent and the solvent of crystallization were investigated.The mol-yield of cefuroxime axetil was over 90% under optimum conditions. |
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| Keywords: | cefuroxime axetil catalyst synthesis |
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