| 生物电子等排原理在农药与医药开发中的应用 |
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| 引用本文： | 宋 倩,梅向东,宁 君.生物电子等排原理在农药与医药开发中的应用[J].河北工业科技,2009,26(2):131-136. |
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| 作者姓名： | 宋 倩 梅向东 宁 君 |
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| 作者单位： | 中国农业科学院植物保护研究所植物病虫害生物学国家重点实验室,北京,100193 |
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| 摘 要： | 在新药创制过程中,先导化合物结构优化是一个重要的环节,生物电子等排取代即为对先导化合物进行合理优化的有效策略之一。介绍了生物电子等排原理的定义和生物电子等排体的分类,通过大量典型事例说明了生物电子等排原理在农药及医药研究中的应用。
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| 关 键 词： | 生物电子等排原理 生物电子等排取代 先导化合物 |
| 收稿时间： | 2008/6/3 0:00:00 |
| 修稿时间： | 2008/9/27 0:00:00 |
Application of bioisosterism in pesticide and medicine development |
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| SONG Qian,MEI Xiang-dong and NING Jun.Application of bioisosterism in pesticide and medicine development[J].Hebei Journal of Industrial Science & Technology,2009,26(2):131-136. |
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| Authors: | SONG Qian MEI Xiang-dong and NING Jun |
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| Institution: | State Key Laboratory for Biology of Plant Diseases and Insect Pests;Institute of Plant Protection of Chinese Academy of Agricultural Sciences;Beijing 100193;China |
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| Abstract: | The structure optimization of lead compounds is very important in the process of new drug development.The bioisosteric replacement is an effectual strategy for the optimization of lead compounds.The definition of bioisosterism was introduced,together with the kinds of the isosters.Some applications of bioisosterism in pesticide and medicine research were illustrated through classic examples. |
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| Keywords: | bioisosterism bioisosteric replacement lead compound |
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