| 2，4，5-三氟苯乙酸的合成研究 |
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| 引用本文： | 刘泽玲.2，4，5-三氟苯乙酸的合成研究[J].河北工业科技,2011,28(4):244-246. |
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| 作者姓名： | 刘泽玲 |
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| 作者单位： | 河北城乡建设学校,河北石家庄,050031 |
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| 摘 要： | 研究了以1，2，4-三氟苯为原料，经Friedel-Crafts酰基化反应、碱性水解重排、氯代和Pd/C催化下甲酸脱氯反应获得首个二肽基肽酶-4(DPP-4)抑制剂西他列汀的起始原料2，4，5-三氟苯乙酸，探讨了催化剂、反应温度等对反应的影响。
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| 关 键 词： | 2 4 5-三氟苯乙酸 1 2 4-三氟苯 西他列汀 |
| 收稿时间： | 2011/1/22 0:00:00 |
| 修稿时间： | 2011/3/9 0:00:00 |
Study on synthesis of 2,4,5-trifluorophenylacetic acid |
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| LIU Ze-ling.Study on synthesis of 2,4,5-trifluorophenylacetic acid[J].Hebei Journal of Industrial Science & Technology,2011,28(4):244-246. |
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| Authors: | LIU Ze-ling |
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| Institution: | School of Hebei Urban and Rural Construction, Shijiazhuang Hebei 050031,China |
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| Abstract: | The preparation of 2,4,5-trifluorophenylacetic acid,which is the starting material of sitagliptin,the first DPP-4 inhibitors,is achieved,with 1,2,4-trifluorobenzene as materials,through Friedel-Crafts acylation,hydrolysis rearrangement in base environment,chlorination and hydrogenolysis catalyzed by Pd/C and formic acid.The effect of the catalyst and temperature were investigated. |
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| Keywords: | 2 4 5-trifluorophenylacetic acid 1 2 4-trifluorobenzene sitagliptin |
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