| 高效液相色谱法测定盐酸咪唑苯脲的含量 |
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| 引用本文： | 张 玉,李金明,刘 波,刘 毅.高效液相色谱法测定盐酸咪唑苯脲的含量[J].河北工业科技,2012,29(2):69-70,81. |
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| 作者姓名： | 张 玉 李金明 刘 波 刘 毅 |
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| 作者单位： | 河北远征药业有限公司,河北石家庄,050041 |
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| 摘 要： | 建立了高效液相色谱法测定盐酸咪唑苯脲的含量。采用Amethyst C18色谱柱(4.6mm×150mm,5μm);以乙腈-缓冲液(缓冲液为5mmol/L辛烷磺酸钠溶液,含0.1%(体积分数)三乙胺,用冰乙酸调节pH值为3.2)为流动相,乙腈与缓冲液体积比为30︰70;流速为1.0mL/min;检测波长为239nm;柱温为30℃。在39.32～137.62μg/mL范围内,盐酸咪唑苯脲峰面积与质量浓度呈良好的线性关系(r=0.999 3),平均回收率约为99.50%(n=9),RSD值约为0.52%。
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| 关 键 词： | 盐酸咪唑苯脲 高效液相色谱法 咪唑苯脲 |
| 收稿时间： | 2011/11/3 0:00:00 |
| 修稿时间： | 2012/1/6 0:00:00 |
Determination of imidocarb hydrochloride by HPLC |
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| ZHANG Yu,LI Jin-ming,LIU Bo and LIU Yi.Determination of imidocarb hydrochloride by HPLC[J].Hebei Journal of Industrial Science & Technology,2012,29(2):69-70,81. |
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| Authors: | ZHANG Yu LI Jin-ming LIU Bo and LIU Yi |
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| Institution: | (Hebei Yuanzheng Pharmaceutical Company Limited,Shijiazhuang Hebei 050041,China) |
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| Abstract: | A method is established for determination of imidocarb hydrochloride by HPLC.The chromatographic column of Amethyst C18(4.6 mm×150 mm,5 μm) is adopted,the mobile phase is acetonitrile-buffer(the buffer is 5 mmol/L sodium octanesulfonate containing 0.1% triethylamine adjusted to pH 3.2 with glacial acetic acid)(30︰70) with 1.0 mL/min of flow rate,the detection wavelength is set at 239 nm and the chromatography is operated at 30 ℃.The linear range is 39.32～137.62 μg/mL(r=0.999 3).The average recovery rate is 99.50%(n=9) and RSD value is 0.52%. |
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| Keywords: | imidocarb hydrochloride HPLC imidazole phenylurea |
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