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高效液相色谱法测定心可舒胶囊中丹参素钠的含量
引用本文:蒋艳红,王润彪,刘丽杰.高效液相色谱法测定心可舒胶囊中丹参素钠的含量[J].中国医药技术经济与管理,2008,2(11):70-74.
作者姓名:蒋艳红  王润彪  刘丽杰
作者单位:1. 石家庄华新制药厂,河北石家庄,050091
2. 河北省药品检验所,河北石家庄,050011
3. 河北以岭医药研究院,河北石家庄,050035
摘    要:目的 建立心可舒胶囊中丹参素钠的含量测定。方法:方法采用色谱柱:Agilent ZORBAX SB—C18(4.6×25mm,5um)色谱柱;流动相:甲醇-2%冰醋酸溶液(4:96);流速:0.8ml·min^-1;检测波长;280nm.结果 丹参素钠在0.044~1.76ug范围内线性关系良好(r=0.9999),平均回收率100.92%,RSD为1.07%。结论本法简便、准确、重现性好,为心可舒胺囊的质量控制提供了依据。

关 键 词:心可舒胶囊  丹参素钠  高效液相色谱法  含量测定

Determination of Danshensu sodium in xinkeshu capsules by HPLC
JIANG Yanhong,WANG Runbiao,LIU Lijie.Determination of Danshensu sodium in xinkeshu capsules by HPLC[J].Chinese Journal of Pharmacentical Technolgy Economics & Management,2008,2(11):70-74.
Authors:JIANG Yanhong  WANG Runbiao  LIU Lijie
Institution:JIANG Yanhong,WANG Runbiao,LIU Lijie(1.Shijiazhuang HuaXin pharmacentical factory,050091,China;2.Institute for drog control of Hebei Province,050011;3.Hebei Yiling Academy of Medicine,Shijiazhang,050035,China)
Abstract:Objective To establish a method for determination of Danshensu sodium in Xinkeshu capsules. Methods An HPLC method was adopted. A Agilent ZOP, BAX SB-C18 Column was used. the mobile phase consisted of methanol-2%acetic acid (4:96). flow rate was 0.8ml · min^-1. the detection wavelength was 280 nm. Results The calibration curve showed a good linear correlation within the concentration range of 0.044 - 1.76ug (r=0.9999) for Danshensu sodium.The average recovery was 100.92%with the RSD of 1.07%. Conclusion The method is simple,accurate and reproducible. It can be used for quality control of Xinkeshu capsules.
Keywords:Xinkeshu capsules  Danshensu sodium  HPLC  determination
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