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C—erbB-2、bcl-2禾口nm23蛋白在结肠癌组织中的表达及意义
引用本文:高艳,张险峰.C—erbB-2、bcl-2禾口nm23蛋白在结肠癌组织中的表达及意义[J].黄石理工学院学报,2011,27(3):51-54.
作者姓名:高艳  张险峰
作者单位:1. 黄石理工学院医学院,湖北黄石,435003
2. 黄石市中心医院消化内科,湖北黄石,435000
摘    要:为探讨C—erbB-2、bcl-2及nm23蛋白在结肠癌组织中的表达及意义,采用免疫组化S—P法检测45例原发性结肠癌组织中C—erbB-2、bcl-2及nm23蛋白的表达。结果为bcl-2、nm23蛋白的表达与结肠癌肿块大小无关(P〉0.05),C—erbB-2的表达与结肠癌肿块大小相关(P〈0.01);c—erbB-2、bcl-2与分化程度相关,nm23蛋白表达与肿瘤分化程度无关(P〉0.05);C—erbB-2、bcl-2、nm23蛋白表达与肿瘤浸润深度、淋巴结转移和远隔转移有关。结论为C—erbB-2、bcl-2和nm23蛋白异常表达在结肠癌发生发展和浸润转移中起重要作用;联合检测C—erbB-2、bcl-2和nm23蛋白对判断结肠癌患者预后和转移有一定的价值。

关 键 词:结肠癌  C—erb  B一2  bel-2  nm23

Expressions and Significances of c-erb B-2,bcl-2 and nm23 Protein in the Colon Carcinoma Tissues
GAO Yan,ZHANG Xianfeng.Expressions and Significances of c-erb B-2,bcl-2 and nm23 Protein in the Colon Carcinoma Tissues[J].Journal of Huangshi Institute of Technology,2011,27(3):51-54.
Authors:GAO Yan  ZHANG Xianfeng
Institution:GAO Yan1 ZHANG Xianfeng2(1 School of Medicine,Huangshi Institute of Technology,Huangshi Hubei 435003,2 Department of Gastroenterology,Huangshi Central Hospital,Huangshi Hubei 435000)
Abstract:Objective:to investigate the expressions and significances of c-erb B-2,bcl-2 and nm23 protein in the colon carcinoma tissues.Methods:the expressions of c-erb B-2,bcl-2 and nm23 protein were determined by immunohistochemical staining in the 45 patients with colon carcinoma.Results:the expressions of bcl-2 and nm23 protein were not correlated with tumor volume(P>0.05),but c-erb B-2 protein had the significant correlation with tumor volume(P < 0.01).The expressions of c-erb B-2,bcl-2 protein were correlated w...
Keywords:colon carcinoma  c-erb B-2  bcl-2  nm23  
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