采用EQ-5D评估2型糖尿病患者的生活质量及影响因素研究

目的：采用EuroQol五维调查问卷表（EQ-5D）对2型糖尿病患者健康相关的生活质量进行评价，并分析其主要影响因素，探讨健康状况发展与生活质量下降的关系。方法：采用EQ-5D问卷及访问，对南京大学附属南京鼓楼医院内分泌门诊256例2型糖尿病患者生活质量和健康状况进行研究。结果全体患者EQ-5D分值平均0．790±0．158。理想控制的患者组平均值0．836（0．810～0．861；95％CI），良好控制和控制差的组的分值分别相当于理想患者的92．2％、84．8％。出现一种或多种并发症的患者分值0．692（0．667～0．717．95％CI），未出现并发症的患者提高到0．863（0．842～0．883,95％CI）。各种并发症的发生发展与血糖控制情况对生活质量影响程度最强。结论：EQ-5D量表适用于中国2型糖尿病患者健康状况测量，适宜成本-效果分析研究。血糖控制不理想和各并发症的发生发展是患者生活质量下降的主要影响因素。

The quality of life of patients with type 2 diabetes measured by EQ-5D and its influential factors analysis

Objective: Use EQ-5D to evaluate the health related quality of life of patients with type 2 diabetes, and analysis the main influence factors. Methods: EQ-5D and interviews were used to study the quality of life and disease states of 256 patients with type 2 diabetes at outpatient. Results: The mean score of all cases was 0.790+0.158. Mean EQ-5D score of patients with ideal blood glucose control group had is 0.836(0.810-0.861; 95%Cl). Mean score of the other two groups were corresponding to 92.2%, 84,8% of that of ideal control group, respectively. Score of patients with one or more diabetes complications was 0.692(0.667-0.717; 95%Cl), while score of patients with no complications increased to 0.863(0.842-0.883; 95%Cl). The occurrence and progression of complications and the blood glucose control condition had great influence on the quality of life. Conclusion: EQ-5D is applied to evaluate the health states of type 2 diabetes patients, and will be useful in cost-effectiveness assessments. Unsatisfied blood glucose control and every complication are the main factors that lower the quality of life of patients.