艾尔巴韦/格拉瑞韦治疗慢性丙型病毒性肝炎的价值评估

目的全面总结评估艾尔巴韦/格拉瑞韦的临床价值、经济价值、病人价值、社会价值,为临床合理用药,减轻患者疾病负担提供参考。方法检索PubMed、Embase、中国期刊全文数据库、中文期刊全文数据库和万方数据知识服务平台等数据库,回顾性分析艾尔巴韦/格拉瑞韦治疗慢性丙型肝炎(CHC)的临床试验研究、真实世界疗效研究以及药物经济学相关研究等资料,总结艾尔巴韦/格拉瑞韦治疗基因1、4型CHC的临床价值、经济价值、病人价值和社会价值。结果在临床价值方面,艾尔巴韦/格拉瑞韦对基因1型或4型CHC患者,以及合并人类免疫缺陷病毒(HIV)、慢性肾脏疾病(CKD)等患者,均具有较高的持续病毒学应答率(SVR)。在经济价值方面,国内外药物经学评价结果显示,艾尔巴韦/格拉瑞韦在治疗CHC基因1(1a,1b)型,以及合并CKD患者中,均具有经济学优势。同时,艾尔巴韦/格拉瑞韦有助于提高病人价值和社会价值,可改善患者身体功能、生理职能、总体健康、情感职能、心理健康等,同时因其可治愈CHC而有助于节约社会生产力,减少疾病传播,具有良好的社会效益。结论艾尔巴韦/格拉瑞韦疗效好,有助于"消除丙肝"目标的实现。

Value Assessment of Elbasvir/Grazoprevir(Zepatier~?) in the Treatment of Chronic Virus Hepatitis C

Objective To comprehensively summarize and evaluate the clinical value,economic value,patient value and social value of Elbasvir/Grazoprevir and to provide reference for the clinical rational medicine use and alleviation of patients’disease burden.Methods PubMed,Embase,CNKI,VIP and Wanfang database were retrieved by computer.Data on clinical trials studies,real-world efficacy studies,and pharmacoeconomics related studies of Elbasvir/Grazoprevir for chronic hepatitis C(CHC)were retrospectively collected.Clinical value,economic value,patient value and social value of Elbasvir/Grazoprevir for the treatment of type 4 CHC were summarized.Results In the aspect of clinical value,Elbasvir/Grazoprevir has high SVR 12(sustained virological response)in patients with genotype 1 or genotype 4 CHC,as well as patients with human immunodeficiency virus(HIV),and patients with chronic kidney disease(CKD)etc.In economic value,the domestic and international pharmacoeconomic evaluation results demonstrated that Elbasvir/Grazoprevir had an economic advantage in the treatment of genotype 1(1 a,1 b)CHC patients and patients with CKD.Meanwhile,Elbasvir/Grazoprevir was helpful for promoting people’s value and social value.It improved physical function,physiological function,overall health,emotional function,mental health,etc.Owing to its CHC cure potential,Elbasvir/Grazoprevir confered substantial values to society by improving work productivity and attenuating CHC epidemic.Conclusion Elbasvir/Grazoprevir has good curative effects,and will be helpful to achieve the goal of eliminating hepatitis C.