抗生素临床合理应用中药学干预的效果

目的探讨在抗生素的临床应用中进行药学干预的效果。方法选取2018年9月至2019年8月于佛山市高明区中医院治疗的患者300例作为研究对象,随机分为对照组和观察组,各150例。对照组进行常规抗生素管理,观察组对抗生素的使用进行药学干预,比较两组抗生素使用情况以及不良反应发生情况。结果观察组抗生素使用种类以及占总医疗费用比例显著低于对照组(t=32.380、χ^2=5.384,P=0.000、0.009);观察组抗生素合理用药率为74.67%显著高于对照组的45.33%(χ^2=26.89,P=0.0000),抗生素滥用、重复用药、不合理使用抗生素比例明显低于对照组(P<0.05);观察组不良反应发生率明显低于对照组(χ^2=11.13,P=0.0008)。结论对抗生素的临床应用进行药学干预可以明显提高抗生素使用的安全性和合理性,对于患者的康复具有促进作用,同时还可以在一定程度上减少患者的治疗费用。

Effects of Rational Clinical Application of Antibiotics in Pharmaceutical Intervention

Objective To explore the effects of pharmaceutical intervention in the clinical application of antibiotics.Methods A total of 300 patients who were treated in the Hospital of Traditional Chinese Medicine in Gaoming District of Foshan City from September 1,2018 to August 31,2019 were randomly divided into a study group and a control group,with 150 cases in each group.The control group received routine antibiotic management,and the study group received pharmaceutical intervention on the use of antibiotics.The use of antibiotics and adverse reactions of the 2 groups were compared.Results The types of antibiotics used in the study group and the proportion in the total medical expenses were significantly lower than those in the control group(t=32.380,χ^2=5.384,P=0.000,0.009);the rational rate of antibiotics used in the study group was 74.67%,significantly higher than 45.33%of the control group(χ^2=26.89,P=0.0000),and the rate of abuse of antibiotics,repeated use of antibiotics and irrational use of antibiotics were significantly lower than those in the control group.The proportion of antibiotic abuse,repeated use,and inappropriate use of antibiotics was significantly lower than that of the control group(P<0.05);The incidence of adverse reactions in the study group was significantly lower than that in the control group(χ^2=11.13,P=0.0008).Conclusion Clinical application of antibiotics in the pharmaceutical intervention can significantly improve the safety and rationality of antibiotic use,promote the rehabilitation of patients,and reduce the treatment costs of patients to a certain extent.