卡前列素氨丁三醇联合缩宫素治疗对产后出血产妇血小板计数、活化部分凝血活酶时间、凝血酶原时间水平的影响

目的探讨卡前列素氨丁三醇联合缩宫素治疗对产后出血产妇血小板计数(PLT)、活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)水平的影响。方法选取2019年6月至2020年2月方大医疗(营口)群众医院妇科收治的78例产后出血产妇作为研究对象,按照抽签方法随机分为对照组和观察组,各39例。对照组患者给予单一缩宫素进行治疗,观察组在对照组治疗基础上联合卡前列素氨丁三醇进行治疗。比较两组PLT、APTT、PT、FIB、治疗有效率、产后1 h及24 h出血量、血流动力学、不良反应发生情况。结果治疗后,观察组PLT、APTT、PT水平高于对照组,FIB水平低于对照组,差异有统计学意义(P<0.05);观察组治疗有效率高于对照组(P<0.05);观察组产后1h及24h出血量少于对照组(P<0.05);治疗后,观察组心率、舒张压、收缩压优于对照组(P<0.05);两组患者不良反应发生率比较差异无统计学意义(P>0.05)。结论对产后出血产妇采用卡前列素氨丁三醇联合缩宫素进行治疗,临床效果显著,使患者PLT、APTT、PT、FIB水平得到改善,减少产妇产后出血量,降低产后大出血发生率,临床治疗安全性较高。

Influence of Carboprost Tromethamine Combined with Oxytocin for Postpartum Blood Platelet Count and Activated Partial Thromboplastin Time,Prothrombin Time Level

Objective To investigate the effect of carboprost tromethamine combined with oxytocin on PLT, APTT and PTlevels in patients with postpartum hemorrhage. Methods A total of 78 patients with postpartum hemorrhage admitted to Fangda Medical(Yingkou) Mass Hospital from June 2019 to February 2020 were selected as the research objects, and were divided into a control group(n=39) and an observation group(n=39) according to the drawing method. The patients in the control group were given single oxytocin treatment, and in the observation group was treated with carboprost tromethamine plus single oxytocin treatment. The PLT, APTT, PT, FIB, curative rate, the bleeding volume, hemodynamics, and adverse reactions after at 1 h and 24 h after delivery were compared. Results After treatment, the PLT, APTT and PT levels were higher than those of the control group, the FIB level was lower than that of the control group, the difference was statistically significant(P<0.05);the effective rate of treatment in the observation group was higher than that in the control group(P<0.05);the bleeding volume of the observation group was less than that of the control group at 1 h and 24 h after delivery(P<0.05);after treatment, the observation group’s heart rate, diastolic blood pressure, and systolic blood pressure were better than the control group(P<0.05);there was no significant difference in the incidence of adverse reactions between the 2 groups(P>0.05). Conclusion The clinical effect of carboprost tromethamine combined with oxytocin in the treatment of postpartum hemorrhage is very significant, which can improve the level of PLT, APTT, Pt and FIB, reduce the amount of postpartum hemorrhage and the incidence of postpartum hemorrhage. The clinical treatment is safe.