MDM2和PTEN基因表达与贲门癌发生发展的相关性

目的 MDM2、PTEN基因表达与贲门癌发生发展关系的研究。方法用免疫组化S-P法检测32例贲门癌组织及18例正常贲门粘膜组织中MDM2和PTEN表达情况。结果贲门癌组织中MDM2表达34.4%,显著高于正常贲门粘膜组织(P<0.05),且与贲门癌淋巴结转移、浸润深度呈正相关。PTEN在贲门癌组织中的表达40.6%,显著低于正常贲门粘膜组织(P<0.05),且与贲门癌淋巴结转移、分化程度相关。结论 MDM2和PTEN异常表达与贲门癌的关系密切,共同参与了贲门癌的发展、转移及浸润。

MDM2and PTEN gene expression and the correlation of the development of gastric cardia cancer

Objective Study on relationship between MDM2,PTEN gene and progression of cardiac carcinoma.Methods Cardiac(n=32),nomal tissues(n=18) were detected for MDM2 and PTEN expression by S-P immunohistochemistry methods.Results The MDM2 protein expression tissues was higher than the normalcardiac tissues(P<0.05),and was related statistically with lymphote metastasis and depth of invasion(P<0.05).The PTEN protein expression was lower than the normal gastric tissues(P<0.05),and was related statistically with lymphotemetastasis and degree of differentiation(P<0.05).Conclusions Abnormal expression of MDM2 and PTEN is closely associated with cardiac carcinoma,which may be contribute in the tumorigenesis,growth and metastasis of gastric carcinoma.