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胶质母细胞瘤PTEN基因突变和Ki-67表达的研究
引用本文:张宏敏.胶质母细胞瘤PTEN基因突变和Ki-67表达的研究[J].中国药物经济学,2013(6):141-142.
作者姓名:张宏敏
作者单位:佛山市第二人民医院,广东佛山,528000
摘    要:目的对胶质母细胞瘤内部PTEN基因突变以及Ki-67表达情况进行研究,并对两者关系展开探讨。方法取胶质瘤石蜡切片102例为研究对象,其中胶质母细胞瘤切片42例,对所选样本行聚合酶链反应-单链构象多态性处理分析(PCR-SSCP),对其PTEN基因突变进行检测;并对Ki-67在胶质瘤中的表达行免疫组化SP检测法进行检测。结果在胶质母细胞瘤中,PTEN基因突变发生率与剩余60例相比明显更高(P〈0.05);在Ki-67平均标记指数方面,胶质母细胞瘤与其它胶质瘤相比数值更高(P〈0.05)。结论在胶质母细胞瘤中,PTEN基因突变对其发生以及发展具有重要作用;其病理恶性程度则与Ki-67表达程度呈明显的正相关;Ki-67表达程度同PTEN基因突变之间的关系也表现为正相关。

关 键 词:PTEN基因  Ki-67表达  胶质母细胞瘤  基因突变

Study on the Expression of Ki-67 and Mutation of PTEN Gene in Glioblastoma
Zhang Hongmin.Study on the Expression of Ki-67 and Mutation of PTEN Gene in Glioblastoma[J].China Journal of Pharmaceutical Economics,2013(6):141-142.
Authors:Zhang Hongmin
Institution:Zhang Hongmin;
Abstract:Objective To study the glioblastoma internal PTEN gene mutation and Ki-67 expression,and to probe into the relationship between the two.Methods 102 cases of gliomas paraffin section as the object of study,including 42 patients with glioblastoma,analysis of the sampling of the polymerase chain reaction,single strand conformation polymorphism(PCR-SSCP) treatment,the PTEN gene mutations were detected;and on the expression of Ki-67 in gliomas immune groups were detected with SP assay.Results In glioblastoma,mutation rate and the remaining 60 cases significantly higher PTEN gene(P0.05);in the average Ki-67 labeling index,glioblastomas compared with other glioma higher(P0.05).Conclusion In glioblastoma,the mutation of PTEN gene plays an important role in the occurrence and development;the malignant degree and the expression of Ki-67 was positively related to the degree of expression of Ki-67 degree;relationship between mutations of the PTEN gene also showed positive correlation.
Keywords:PTEN gene  Ki-67 expression  Glioma  Gene mutation
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