肠易激综合征患者抑郁及焦虑程度与调节性T细胞的关系

目的探讨肠易激综合征患者抑郁及焦虑程度与调节性T细胞的关系。方法以72例肠易激综合征患者及36例同期体检的健康人员为研究对象,依据抑郁自评量表及焦虑自评量表的结果,将研究对象分为三组:36例伴有抑郁焦虑的肠易激综合征患者为观察组,36例不伴有抑郁焦虑的肠易激综合征患者为对照1组,36例健康体检者为对照2组;对所有研究对象的CD+4、CD+8、CD+4/CD+8等调节性T细胞进行检测并进行组间比较。结果观察组研究对象的抑郁及焦虑评分均高于对照组,差异有统计学意义(P<0.05);而对照组间的抑郁及焦虑评分差异有统计学意义(P>0.05);观察组研究对象的CD+4水平和CD+4/CD+8值均低于两组对照组,而CD+8水平高于两组对照组,差异有统计学意义(P<0.05);对照组1组的CD+4水平和CD+4/CD+8值均低于对照2组,而CD+8水平高于对照2组,差异有统计学意义(P<0.05)。结论肠易激综合征患者抑郁及焦虑程度与调节性T细胞具有一定的相关性,可证实精神心理状态对肠易激综合征的发病及治疗具有重要意义。

Relationship between Irritable Bowel Syndrome and Depression and Anxiety and Regulatory T cells

Objective To investigate the correlation between the degree of depression/anxiety among patients with irritable bowel syndrome（IBS）and the level of Th cels.Methods A total of 72 IBS patients and 36 wel~matched healthy individuals were included in the study and accordingly assigned to each of the folowing 3 groups：IBS with depression/anxiety（Observation;n=36）,IBS without depression/anxiety（Control 1;n=36）and healthy individuals （Control 2;n=36）.Levels of CD＋4,CD＋8,CD＋4/CD＋8 were obtained in al subjects for group comparisons.Results Scoring of depression/anxiety in Observation group was significantly higher than that in either of the control groups（P〈0.05）, whereas such scoring in both control groups was similar（P〉0.05）.For the observation group,as compared with either of the control groups,levels of CD＋4 and CD＋4/CD＋8 were significantly higher while level of CD＋8 was significantly lower （P〈0.05）.A similar trend was also found in the comparison of control 1 vs.control 2（P〈0.05）.Conclusion The degree of depression/anxiety in patients with IBS seemed to be correlated with the level of Th cels,which indicated that psychological factors may play an important role in the pathogenesis and management of IBS.