巴拉圭茶对高脂血症小鼠血脂的影响

目的:探讨不同剂量巴拉圭茶对高脂血症小鼠血脂的影响。方法:通过高脂日粮建立高脂血症小鼠模型,随机分为模型组、巴拉圭茶低剂量组、巴拉圭茶高剂量组,对照组饲喂基础日粮,模型组饲喂高脂日粮,巴拉圭茶低剂量组、巴拉圭茶高剂量组饲喂高脂日粮并分别灌胃1 g·kg^-1、2 g·kg^-1巴拉圭茶,连续灌胃4周,处死小鼠,测定小鼠血清中总胆固醇、甘油三酯、高密度脂蛋白胆固醇和低密度脂蛋白胆固醇的含量。结果:与模型组相比,低剂量和高剂量巴拉圭茶均可显著降低高脂血症小鼠血清中的总胆固醇、甘油三酯、低密度脂蛋白胆固醇含量(p<0.05),高剂量巴拉圭茶可显著提高小鼠血清中高密度脂蛋白胆固醇含量(p<0.05)。结论:巴拉圭茶对调节高脂血症小鼠血脂代谢具有一定的作用。

Effect of Yerba Mate on Blood Lipid in Hyperlipidemia Mice

Objective:To investigate the effect of different doses of yerba mate on blood lipids in hyperlipidemia mice.Methods:A hyperlipidemia mouse model was established through a high-fat diet and randomly divided into a model group,a low-dose yerba mate group,and a high-dose yerba mate group.The control group was fed a basal diet,and the model group was fed a high-fat diet The low-dose yerba mate group and the high-dose yerba mate group were fed a high-fat diet and gavage 1 g·kg^-1 and 2 g·kg^-1 yerba mate respectively for 4 weeks.The content of total cholesterol,triglycerides,high density lipoprotein cholesterol and low density lipoprotein cholesterol in rat serum.Results:Compared with the model group,both low-dose and high-dose yerba mate can significantly reduce the total cholesterol,triglyceride,and low-density lipoprotein cholesterol content in the serum of hyperlipidemia mice(p<0.05).High-dose yerba mate can significantly increase the high-density lipoprotein cholesterol content in the serum of mice(p<0.05).Conclusion:Yerba mate has a certain effect on regulating blood lipid metabolism in hyperlipidemia mice.