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1.
Estimation in the interval censoring model is considered. A class of smooth functionals is introduced, of which the mean is an example. We consider case 2, with two observation times for each unobservable event time, in the situation that the observation times cannot become arbitrarily close to each other. It is proved that the nonparametric maximum likelihood estimator of the functional asymptotically reaches the information lower bound. 相似文献
2.
In this paper, we discuss the inference for the competing risks model when the failure times follow Chen distribution. With assumption of two causes of failures, which are partially observed, are considered as independent. The existence and uniqueness of maximum likelihood estimates for model parameters are obtained under generalized progressive hybrid censoring. Also, we discussed the classical and Bayesian inferences of the model parameters under the assumption of restricted and nonrestricted parameters. Performance of classical point and interval estimators are compared with Bayesian point and interval estimators by conducting extensive simulation study. In addition to that, for illustration purpose, a real life example is discussed. Finally, some concluding remarks, regarding the presented model, are made. 相似文献
3.
讨论了定数截尾样本下,指数分布环境因子的极大似然估计和区间估计,为研究估计的精度,运用随机模拟方法,对环境因子的置信区间的精度进行了讨论。 相似文献
4.
M. J. van der Laan 《Statistica Neerlandica》1997,51(2):178-200
A large number of proposals for estimating the bivariate survival function under random censoring have been made. In this paper we discuss the most prominent estimators, where prominent is meant in the sense that they are best for practical use; Dabrowska's estimator, the Prentice–Cai estimator, Pruitt's modified EM-estimator, and the reduced data NPMLE of van der Laan. We show how these estimators are computed and present their intuitive background. The asymptotic results are summarized. Furthermore, we give a summary of the practical performance of the estimators under different levels of dependence and censoring based on extensive simulation results. This leads also to a practical advise. 相似文献
5.
Lu Mao 《Statistica Neerlandica》2019,73(3):395-413
We present a nonparametric study of current status data in the presence of death. Such data arise from biomedical investigations in which patients are examined for the onset of a certain disease, for example, tumor progression, but may die before the examination. A key difference between such studies on human subjects and the survival–sacrifice model in animal carcinogenicity experiments is that, due to ethical and perhaps technical reasons, deceased human subjects are not examined, so that the information on their disease status is lost. We show that, for current status data with death, only the overall and disease‐free survival functions can be identified, whereas the cumulative incidence of the disease is not identifiable. We describe a fast and stable algorithm to estimate the disease‐free survival function by maximizing a pseudo‐likelihood with plug‐in estimates for the overall survival rates. It is then proved that the global rate of convergence for the nonparametric maximum pseudo‐likelihood estimator is equal to Op(n?1/3) or the convergence rate of the estimated overall survival function, whichever is slower. Simulation studies show that the nonparametric maximum pseudo‐likelihood estimators are fairly accurate in small‐ to medium‐sized samples. Real data from breast cancer studies are analyzed as an illustration. 相似文献
6.
In this paper firstly a summary of the theory of competing risks is presented; it shows how cause specific failure time distributions, failure probabilities and failure rate functions relate to the joint survivor function in the presence of various competing failure causes. This first part of the paper gives the insight useful for the second part, which concerns the way in which the dependency of the failure process on given time–dependent observations of covariables is specified and estimated. An application is presented briefly. 相似文献
7.
8.
Accelerated life testing of products is used to get information quickly on their lifetime distributions. This paper discusses a k -stage step-stress accelerated life test under progressive type I censoring with grouped data. An exponential lifetime distribution with mean life that is a log-linear function of stress is considered. A cumulative exposure model is also assumed. We use the maximum likelihood method to obtain the estimators of the model parameters. The methods for obtaining the optimum test plan are investigated using the variance-optimality and D-optimality criteria. Some numerical studies are discussed to illustrate the proposed criteria. 相似文献
9.
Maximum likelihood methods for fitting the burr type XII distribution to multiply (progressively) censored life test data 总被引:2,自引:0,他引:2
Dallas R. Wingo 《Metrika》1993,40(1):203-210
Summary This paper develops mathematical and computational methodology for fitting, by the method of maximum likelihood (ML), the
Burr Type XII distribution to multiply (or progressively) censored life test data. Mathematical expressions are given for
approximating the asymptotic variances and covariances of the ML estimates (MLEs) of the parameters of the Burr Type XII distribution.
A rigorous mathematical analysis is undertaken to investigate the existence and uniqueness of the MLEs for arbitrary sample
data. The methodology of this paper is applied to progressively censored sample data arising in a life test experiment. 相似文献
10.
Anthony Y. C. Kuk 《Revue internationale de statistique》2020,88(3):715-727
A brief survey on methods to handle non-proportional hazards in survival analysis is given with emphasis on short-term and long-term hazard ratio modelling. A drawback of the existing model of this nature is that except at time zero or infinity, the hazard ratio for a unit increase in the value of a covariate depends on the starting value. With two or more covariates, the hazard ratio for a unit increase in one covariate with other covariates held fixed depends in an unintended way on the values of the other covariates. We propose an alternative way to model short-term and long-term hazard ratios without the above drawbacks through a judicious choice of covariate-time interactions. Under the new model, it is easier to describe the time-varying effect of each covariate on the hazard. Nonparametric maximum likelihood estimation for the new model can be carried out in the same way as for the existing model. We also propose a product version of the existing model, which overcomes its second drawback but not the first. The advocated covariate–time interaction model provides a better fit to the Veterans Administration lung cancer data set than the original and product versions of the existing model. 相似文献
11.
D. Ghosh 《Statistica Neerlandica》2001,55(3):367-376
For current status data, L IN , O AKES and Y ing (1998) proposed a procedure for estimation of the regression parameters in the additive hazards model that makes clever use of martingale theory. However, one of the outstanding problems posed in the paper was the issue of efficient estimation, as their estimators do not attain the semiparametric information bound. In this paper, we explore this issue and provide a characterization of the NPMLE. We conduct efficiency comparisons between the NPMLE and the procedure of L IN et al . (1998) analytically and numerically through analysis of a dataset from a tumorigenicity experiment. 相似文献
12.
We give a new proof of the identifiably of the MPH model. This proof is constructive: it is a recipe for constructing the triple—regression function, base-line hazard, and distribution of the individual effect—from the observed cumulative distribution functions.
We then prove that the triples do not depend continuously on the observed cumulative distribution functions. Uniformly consistent estimators do not exist.
Finally we show that the MPH model is even identifiable from two-sided censored observations. This proof is constructive, too. 相似文献
We then prove that the triples do not depend continuously on the observed cumulative distribution functions. Uniformly consistent estimators do not exist.
Finally we show that the MPH model is even identifiable from two-sided censored observations. This proof is constructive, too. 相似文献
13.
Asymptotic normality of the NPMLE of linear functionals for interval censored data, case 1 总被引:2,自引:0,他引:2
We give a new proof of the asymptotic normality of a class of linear functionals of the nonparametric maximum likelihood estimator (NPMLE) of a distribution function with "case 1" interval censored data. In particular our proof simplifies the proof of asymptotic normality of the mean given in Groeneboom and Wellner (1992). The proof relies strongly on a rate of convergence result due to van de Geer (1993), and methods from empirical process theory. 相似文献
14.
《Statistica Neerlandica》2018,72(1):34-47
In intensive care units (ICUs), besides routinely collected admission data, a daily monitoring of organ dysfunction using scoring systems such as the sequential organ failure assessment (SOFA) score has become practice. Such updated information is valuable in making accurate predictions of patients' survival. Few prediction models that incorporate this updated information have been reported. We used follow‐up data of ICU patients who either died or were discharged at the end of hospital stay, without censored cases. We propose a joint model comprising a linear mixed effects submodel for the development of longitudinal SOFA scores and a proportional subdistribution hazards submodel for death as end point with discharge as competing risk. The two parts are linked by shared latent terms. Because there was no censoring, it was straightforward to fit our joint model using available software. We compared predictive values, based on the Brier score and the area under the receiver operating characteristic curve, from our model with those obtained from an earlier modeling approach by Toma et al . [Journal of Biomedical Informatics 40, 649, (2007)] that relied on patterns discovered in the SOFA scores over a given period of time. 相似文献
15.
Estimation in the interval censoring model is considered. A class of smooth functionals is introduced, of which the mean is an example. The asymptotic information lower bound for such functionals can be represented as an inner product of two functions. In case 1, i.e. one observation time per unobservable event time, both functions can be given explicitly. We mainly consider case 2, with two observation times for each unobservable event time, in the situation that the observation times can not become arbitrarily close to each other. For case 2, one of the functions in the inner product can only be given implicitly as solution to a Fredholm integral equation. We study properties of this solution and, in a sequel to this paper, prove that the nonparametric maximum likelihood estimator of the functional asymptotically reaches the information lower bound. 相似文献
16.
M. Schemper 《Statistica Neerlandica》1987,41(1):59-64
While jackknife and bootstrap estimates of the variance of a statistic are well–known, the author extends these nonparametric maximum likelihood techniques to the estimation of skewness and kurtosis. In addition to the usual negative jackknife also a positive jackknife as proposed by BERAN (1984) receives interest in this work. The performance of the methods is investigated by a Monte Carlo study for Kendall's tau in various situations likely to occur in practice. Possible applications of these developments are discussed. 相似文献
17.
A randomized two‐stage adaptive design is proposed and studied for allocation of patients to treatments and comparison in a phase III clinical trial with survival time as treatment responses. We consider the possibility of several covariates in the design and analysis. Several exact and limiting properties of the design and the follow‐up inference are studied, both numerically and theoretically. The applicability of the proposed methodology is illustrated by using some real data. 相似文献
18.
《Spatial Economic Analysis》2013,8(4):467-483
Abstract This paper discusses the maximum likelihood estimator of a general unbalanced spatial random effects model with normal disturbances, assuming that some observations are missing at random. Monte Carlo simulations show that the maximum likelihood estimator for unbalanced panels performs well and that missing observations affect mainly the root mean square error. As expected, these estimates are less efficient than those based on the unobserved balanced model, especially if the share of missing observations is large or spatial autocorrelation in the error terms is pronounced. Estimation de vraisemblance maximale d'un modèle général d'effets aléatoires spatiaux déséquilibré: une étude Monte Carlo RÉSUMÉ La présente communication se penche sur l'estimateur du maximum de vraisemblance d'un modèle général d'effets aléatoires spatiaux déséquilibré avec des perturbations normales, en supposant l'absence aléatoire de certaines observations. Des simulations de Monte Carlo montrent que des groupes déséquilibrés se comporte bien, et que les observations manquantes affectent principalement l'erreur de la moyenne quadratique. Comme prévu, ces évaluations sont moins efficaces que celles qui sont basées sur le modèle équilibré non observé, notamment si la part des observations manquantes est importantes, ou l'on déclare une autocorrélation spatiale dans les termes d'erreur. Estimación de la probabilidad máxima de un modelo espacial general desequilibrado de efectos al azar: un estudio de Monte Carlo RÉSUMÉN Este trabajo discute el estimador de probabilidad máxima de un modelo espacial general desequilibrado de efectos al azar con alteraciones normales, suponiendo que faltan algunas observaciones al azar. Las simulaciones de Monte Carlo muestran que el estimador de probabilidad máxima para los paneles desequilibrados funciona satisfactoriamente, y que las observaciones omisas afectan principalmente al error de la media cuadrática. Como se suponía, estas estimaciones son menos eficientes que las basadas en el modelo equilibrado inadvertido, especialmente si la cantidad de omisiones es grande/o la autocorrelación en los términos de error es pronunciada. 相似文献
19.
In this paper, we develop procedures for obtaining confidence intervals for the parameters of a Laplace distribution as well as upper and lower γ probability tolerance intervals for a proportion β, given a progressively Type-II right censored sample from the Laplace distribution. The intervals are obtained by conditioning on the observed values of the ancillary statistics. The intervals are exact, do not require numerical integration, and generalize the work of Childs and Balakrishnan (1996) who considered the conventional Type-II right censored case. Received: February 2000 相似文献
20.
Dragi Anevski 《Statistica Neerlandica》2003,57(2):245-257
We obtain a relation between the time between two bird-catchings and the total resting period of a bird, leading to the problem of estimating the derivative of a convex density. We state a fundamental result on the nonparametric maximum likelihood estimator of a convex density. Further, we derive the optimal rate in the minimax risk sense for estimating the derivative of a convex density. 相似文献