Supply chain planning of vaccine and pharmaceutical clusters under uncertainty: The case of COVID-19

As an abrupt epidemic occurs, healthcare systems are shocked by the surge in the number of susceptible patients' demands, and decision-makers mostly rely on their frame of reference for urgent decision-making. Many reports have declared the COVID-19 impediments to trading and global economic growth. This study aims to provide a mathematical model to support pharmaceutical supply chain planning during the COVID-19 epidemic. Additionally, it aims to offer new insights into hospital supply chain problems by unifying cold and non-cold chains and considering a wide range of pharmaceuticals and vaccines. This approach is unprecedented and includes an analysis of various pharmaceutical features such as temperature, shelf life, priority, and clustering. To propose a model for planning the pharmaceutical supply chains, a mixed-integer linear programming (MILP) model is used for a four-echelon supply chain design. This model aims to minimize the costs involved in the pharmaceutical supply chain by maintaining an acceptable service level. Also, this paper considers uncertainty as an intrinsic part of the problem and addresses it through the wait-and-see method. Furthermore, an unexplored unsupervised learning method in the realm of supply chain planning has been used to cluster the pharmaceuticals and the vaccines and its merits and drawbacks are proposed. A case of Tehran hospitals with real data has been used to show the model's capabilities, as well. Based on the obtained results, the proposed approach is able to reach the optimum service level in the COVID conditions while maintaining a reduced cost. The experiment illustrates that the hospitals' adjacency and emergency orders alleviated the service level significantly. The proposed MILP model has proven to be efficient in providing a practical intuition for decision-makers. The clustering technique reduced the size of the problem and the time required to solve the model considerably.     

A socio-economic optimization model for blood supply chain network design during the COVID-19 pandemic: An interactive possibilistic programming approach for a real case study

In uncertain circumstances like the COVID-19 pandemic, designing an efficient Blood Supply Chain Network (BSCN) is crucial. This study tries to optimally configure a multi-echelon BSCN under uncertainty of demand, capacity, and blood disposal rates. The supply chain comprises blood donors, collection facilities, blood banks, regional hospitals, and consumption points. A novel bi-objective Mixed-Integer Linear Programming (MILP) model is suggested to formulate the problem which aims to minimize network costs and maximize job opportunities while considering the adverse effects of the pandemic. Interactive possibilistic programming is then utilized to optimally treat the problem with respect to the special conditions of the pandemic. In contrast to previous studies, we incorporated socio-economic factors and COVID-19 impact into the BSCN design. To validate the developed methodology, a real case study of a Blood Supply Chain (BSC) is analyzed, along with sensitivity analyses of the main parameters. According to the obtained results, the suggested approach can simultaneously handle the bi-objectiveness and uncertainty of the model while finding the optimal number of facilities to satisfy the uncertain demand, blood flow between supply chain echelons, network cost, and the number of jobs created.