The (Failed) Development of a Biotechnology Cluster: The Case of Lombardy

This paper discusses the development of the biotechnology industry in an Italian region, Lombardy. It asks why significant innovative activities in biotechnology did not emerge in what might have been considered at the outset a promising area for the growth of this industry and why in very recent years some timid symptoms of dynamism seem to be appearing. After an overview of the patterns of the development of biotechnology in Italy, the specific case of Lombardy, is described. Then, the paper discusses what kind of factors might explain the lagging behind of the Italian (and more generally, European) biotechnology industry vis-à-vis the United States.     

中小生物技术企业创业融资问题研究

世界现代生物技术发展已经进入大规模产业化阶段,生物技术企业是产业化的主要推动力量。我国生物技术企业普遍存在融资困难的问题．既有高新技术产业在融资中存在的普遍性问题,也有其自身的特殊问题。阐述生物产业特征与融资特点,分析我国生物技术企业融资现状和存在的问题,并提出政策建议。     

Service bundling and strategic equilibrium in the information services industry

The information service industry is characterized by successive levels of access; e.g., network service and data base service. Within this structure firms may have incentives to bundle services and exclude independent service providers from media access. This multilevel structure is incorporated into mathematical models that can be used to characterize interactions between unregulated firms in a variety of industries, including switched network services, software, and television.Incentives for vertical merger between complementary service providers are evaluated for several cases. We show that cross subsidy occurs under vertical merger, and that the likelihood of merger is greatest when one of the firms can unilaterally exclude other complementary firms from media access. In this case the access controlling firm is in a position to enforce bundled pricing and limit the availability of independently supplied services. This ability to bundle services leads to cross subsidy and merger, even in the absence of economies of scale or scope.     

The Dynamics of Industrial Clustering in Biotechnology

This paper is a study of the process by which industrial clusters form. It identifies the forces of attraction to new companies to a cluster in biotechnology in the U.S. as it grows. It uses a model of entry of new firms into the industry to measure the degree of attraction to those new firms of the presence of an existing cluster at a particular location. The paper finds that the main agent of attraction to new firms to enter the biotechnology industry is the presence of a strong science base at that location. This provides a greater magnet than the strength of any particular sector of the industry. In terms of attraction between different sectors within the industry, the paper finds that there is positive attraction and feedback between a group of sectors in the biotechnology industry – namely the therapeutics, diagnostics and the equipment/research tools sector. However in other sectors of the industry – chemicals, food and to some extent agriculture – there is much less attraction and interaction between them. This implies that clusters of firms tend to develop only in particular sectors of the industry and positive feedback mechanisms do not extend to other parts of the industry.     

Early‐Stage of Innovations: Selection System Criteria for Funding U.S. Biotech SMEs

The focus of this paper is small and medium‐sized enterprises (SMEs) operating in the U.S. biotechnology industry and how they compete for financial resources during the early stages of innovation development. We utilize selection system theory, which describes how selectors use reputation‐based information about selectees as decision factors when making investments. Our findings suggest that there are different predictive variables for SME categories and the types of investors attracted to these categories, which is consistent with selection system theory. We extend prior studies by providing context to early‐stage innovation investment funding within an environment characterized as having a long development cycle and representing high uncertainty.     

区域物流产业专业化的现状分析与发展对策——以陕西省为例

专业化产业指一个区域内直接或间接为外区域提供商品或劳务的产业.从西部地区来看,现阶段陕西省物沈产业专业化水平低,还不能成为向西部地区输出物流服务和产品的物流专业化部门.文章提出,影响物流业发展的因素很多,可利用因子分析法,分别从物流需求、物流供给、物流平台、物流组织四个方面选取指标,剖析陕西省物流业发展落后的原因.研究发现,陕西省物流业发展综合水平不高,物流运作供给能力较强,经济环境和运输空间条件等因素制约了物流业的发展.文章指出,为促进陕西省物流业发展,提升其专业化优势,应深化物流业管理体制改革,完善物流产业政策,落实陕西省现代物流业发展规划;积极培育物流市场,整合物流资源,推进企业物流向社会物流转化:搭建统一的物流要素平台,加强物流新技术的应用和开发,促进关键物流技术和产品的产业化;建立物流市场信息预警与监督机制,完善行业协会管理职能.     

Biotechnology Firms in Sweden

The purpose of this study is to create an understanding of the strategies that biotechnology firms in Sweden implement, how they manage to keep their competence ahead and how they finance their research. Their main factor of success is the ability to rapidly identify the latest research findings from academia and turn them into commerciable technology. The collaboration with academia is thus an important part of the networking strategy of the biotechnology firms in Sweden. Outsourcing parts of their activities keeps the firms flexible, which is necessary in this high risk business.Whether a firm chooses an intermediary or integrating position is not found to be correlated to age or size. It is instead heavily influenced by the strategies of large pharmaceutical companies, the nature of the firms' core technology, expectations of investors and the overall access of capital. The private capital market in Sweden has undergone a change during the last years. New marketplaces for young, innovative firms have been created in Sweden and their existence is most likely one reason for the increasing presence of venture capitalists in the country. That, in turn, increases the opportunities for new firms within biotechnology to develop in Sweden.     

The role of incubator organizations in the founding of growth-oriented firms

The role of incubator organizations, those organizations where entrepreneur work before starting their own firms, is examined. Using a sample of 161 new, growth-oriented firms, the relationships of the new companies to their incubator organizations are considered, as well as the characteristics of the incubator organizations. 5The findings have implications for prospective entrepreneurs. Entrepreneurs in most industry categories do not change geographic location and, in most technical industries, usually start businesses related to what they did before. An individual's decision to join a particular organization results in a particular geographic location and in knowledge about a particular industry. The would-be founder located in an unpromising geographic area and getting experience in an industry offering few opportunities for company start-ups is unlikely to be able to start a growth-oriented technical firm, regardless of personal motivation. However, the prospective founder of a nontechnical firm appears to be less tied to the experience gained in an incubator organization.There are also implications for regional economic development. Because technically oriented start-ups are tied closely to the business of their incubator organizations and because most entrepreneurs don't move when starting, the possibilities for high-technology start-ups may be very limited in many geographic regions. There have been no studies, to date, on why some founders move when starting. Programs to attract entrepreneurs at the time of start-up may have promise, but, at least to date, there is not much evidence of entrepreneurs being mobile at this stage of their careers.Local and regional programs to attract branch facilities of larger corportions have a long history. The emphasis is usually upon attracting facilities that will offer the maximum number of blue-collar jobs. In contrast to this traditional approach, it might be beneficial to shift the emphasis to those facilities most likely to function as incubators. The greatest benefits might come from laboratories or divisions that would “seed” a region with people learning about promising technologies or industries.The role of universities in this process appears to be less direct than is often assumed. Based upon our sample, it appears that software and biotechnology/medical firms often have spun-off from universities or hospitals. However, in other industry categories, it is business firms that have primarily served as incubators. There are currently many experiments underway to create university-affiliated innovation centers or incubator centers intended to help aspiring entrepreneurs. Whether these will enable universities to function more effectively as incubators, spinning off students and faculty who start growth-oriented firms, remains to be seen.     

A Dynamic Model of Size Distribution of Firms Applied to U.S. Biotechnology and Trucking Industries

The present paper attempts to contribute to the existing literature on industry dynamics by proposing a tractable structure for the analysis of the dynamic process governing the size distribution of firms. An analytical model is proposed which describes the density of the cross-sectional distribution of firm size within an industry. The model is based on the theory of diffusion processes, and the method illustrates how information on the time-evolution of size distribution of firms over an extended period of time can be used to make inferences about an underlying process. An empirical application to the evolution of size distribution of population of firms in (i) the U.S. biotechnology industry, and (ii) the U.S. interstate for-hire trucking industry illustrates the applicability of the proposed model in industry studies.     

Biotechnology in the textile/clothing industry – a review

Summary: This paper focuses on the use of biotechnology in the textile/clothing industry by identifying where and how such processes are already established and considers the latest developments, either in the research stage or in the early stages of commercialization. It has been found that biotechnology systems are already well known to those involved in fabric preparation, particularly as regards desizing. Enzymes used in detergent formulations have also been successfully used for the past 30–40 years. Most recent commercial advances have been in fabric finishing processes where handle modifications to cotton fabrics in particular are fast becoming established. Cutting-edge research falls in the areas of fibre modification and the generation of new fibres from natural sources, such as natural polyester from bacteria. The isolation of DNA from the shaft of hair fibres and the encoding of detectable specific antigens to designer labels is providing new ways of helping to combat fraud and counterfeit in the fashion trade. The treatment of textile effluent continues to be a major problem to the industry, but here, biotechnological developments in other industries are helping to provide some answers.     

The Fourth Pillar? An assessment of the Situation of the Finnish Biotechnology

The success in constructing a flourishing information and telecommunication cluster has encouraged Finland to seek equal possibilities in other knowledge-intensive industrial branches. Presently, biotechnology is seen as an auspicious business area. Like in other parts of Europe, Finnish biotechnology concentrates mainly on pharmaceutical industries. More than 70 percent of the human resources of Finnish biotechnology industries is settled in this industrial branch.Despite large investments and financing, modern biotechnology industries are still a marginal industrial branch in the Finnish economy. Its turnover in 1999 was only one percent of the total GNP. The wide spectrum of Finnish higher education and the close relations of co-operation between universities and industries can open up promising prospects. Finland's technology-affirmative attitudinal climate works in the same direction. This progress can be delayed by a lack of highly skilled human resources, which is already a problem in the IT sector. The small size and minor experience in global markets have also limited the success of the Finnish firms.     

日本经济起飞时期农村劳动力供给机制研究

20世纪60年代,伴随着日本经济起飞,城市加工产业对劳动力的需求急剧扩大,在城乡巨大收入差距的诱惑下,日本农村的青壮年劳动力大量涌入城市,造成农村劳动力严重短缺,在农户家庭内部劳动力互补机制的作用下,缓解了劳动力不足,在一定程度上稳定了农业生产。从分析日本经济起飞时期农村劳动力的结构变动入手,通过实证分析把握劳动力供给结构变化的经济影响;进而分析未来日本劳动力供给结构变化的趋势,在此基础上结合中国的实际情况说明农村劳动力互补机制对于城市化进程中中国农村的借鉴意义。     

Consumers and Biotechnology: A Synopsis of Survey and Focus Group Research

The Office of Consumer Affairs of Industry Canada, in conjunction with other federal departments, has undertaken preliminary work to identify concerns and highlight consumer issues with respect to biotechnology and its applications. This has included conducting a number of surveys and focus groups to identify what consumers know about biotechnology; where there are information gaps; and how information impacts upon consumers' purchasing decisions.This paper is structured into five sections. First, it provides an overview of some background information on biotechnology. The second section summarises consumers' knowledge of, and reactions to, biotechnology. Next, the paper highlights factors that influence consumers' attitudes towards biotechnology. The fourth section examines two ways of overcoming marketplace barriers contrasting increased consumer awareness with more traditional legislative mechanisms. The concluding section outlines questions that need to be answered in order to determine how the marketplace can best address issues related to biotechnological products.     

Factors influencing the search for information about genetically modified food products

A recent application of biotechnology to food is genetic modification. Genetically modified (GM) plants, animals and processed foods have been introduced to the international marketplace in the 1990s. As scientific and technological progress in modern biotechnology continues at a breakthrough pace, the consumers are presented with different types and levels of information that is potentially relevant for making choices. Findings from studies of consumer attitudes and awareness towards GM products have varied greatly. Many studies, however, have indicated that public opinions about GM products are not fully formed and the task of informing the public is far from over. This study expands on previous research by examining the factors that influence the search for information about GM products. Utilizing the theory of consumer behaviour and information search, we analyse consumers’ information search patterns about GM products. Specifically, we estimate the probability that consumers search for information actively, passively or do not search for information at all, and the factors influencing this search. An ordered probit model is formulated to measure the factors, both economic and behavioural, that influence in‐formation search by consumers for GM products. Variables representing the informational attitudes and behaviour related to GM products have the greatest impact on the probability of searching for information about GM products. With the exception of age, demographic factors are not significant. The results point to information search, not, for the genetically modified characteristic, but instead for the absence of the characteristic.     

人文精神、政府职能对区域经济的作用——义乌市“专业市场+会展”经济发展模式研究

浙江义乌"专业市场+会展"的产业发展模式极具特色,在土地、资源、人力相对缺乏的条件下,通过创办市场,发展会展产业,推动区域经济迅速增长,被誉为"无中生有"的发展模式。发达的会展与贸易产业、特色鲜明的专业市场、逐渐壮大的浙中商圈、藏富于民的城乡一体化经济都是义乌经济发展的显著特色。这些经济现象背后,剔除贫困的"诱变"因素之外,温州模式的影响、义乌的人文精神是最大的推动力。     

Managing radical innovation: The importance of specialized knowledge in the biotech revolution

This work has implications for managers, investors and entrepreneurs in times of breakthrough innovation at the firm or industry level. The work shows that the marketplace understands the importance of retaining and motivating critical specialized knowledge. By analyzing initial public offerings during the biotechnology discovery wave I find evidence that a dramatic decrease in the ability to include secondary shares (liquidity for early investors and entrepreneurs) in biotechnology IPOs corresponds with the radical increase in the importance of specialized knowledge in that industry, at the time of the rDNA breakthrough discovery and development.     

Analysing the link between export intensity,innovation and firm size in a science-based industry

The aim of this paper is to contribute to a better understanding of the relationship between export intensity, innovation and size in a particular technological setting: a science-based industry. Using a sample of 121 firms in the French biotechnology industry, we have found that firm size is not a determinant for innovation or for export intensity. However, the results show a positive and significant link between innovation and export intensity. Our findings open a new agenda for policy-makers when interpreting how they should promote innovation and exports in science-based firms.     

外商直接投资与我国农产品和食品贸易关系的研究

本文运用计量经济模型,对我国农产品和食品贸易与FDI之间的关系进行了研究,结果表明我国农产品和食品进口、出口和总贸易量与FDI之间皆存在长期稳定的均衡关系,而且这种关系具有互补性。在此基础上,本文还对各变量之间是否存在因果关系进行了检验,以便进一步揭示二者之间的联系。同时结合我国农产品和食品贸易与FDI的特点,对结果进行了相应的讨论。     

STRATEGIC MANDATORY LABELING OF BIOTECHNOLOGY PRODUCTS IN THE ABSENCE OF QUALITY DIFFERENCE

This article examines the strategic use of mandatory labeling of biotechnology products, such as genetically modified food. A foreign dominant firm produces a biotechnology product and foreign competitive firms produce a conventional one. It is shown that if other trade measures such as tariffs are also available, the government of an importing country may impose mandatory labeling even in the case where there is no quality difference between biotechnology and conventional products. A combination of a discriminatory tariff on the biotechnology product and mandatory labeling shifts rents from the foreign dominant firm to the domestic economy.     

The effects of business–university alliances on innovative output and financial performance: a study of publicly traded biotechnology companies

Companies in the biotechnology industry face major challenges in developing and commercializing new products. Focusing on publicly traded biotechnology firms that are not members of university incubators or research parks, this paper argues that the links these companies develop with universities can have beneficial effects on a company's operations. Analysis of 2457 alliances undertaken by 147 biotechnology firms shows that companies with university linkages have lower research and development (R&D) expenses while having higher levels of innovative output. However, the results do not support the proposition that companies with university linkages achieve higher financial performance than similar firms without such linkages.