The globalisation of research in the pharmaceutical industry: A case of uneven development

The paper discusses different conceptualisations of the term globalisation of research. From this discussion five dimensions of globalisation of research are identified. Using three different type of data, the paper goes on to examine the extent, motivations and mechanism for the globalisation of research along these five dimensions among leading European and US pharmaceutical multinational companies (MNCs). The evidence for the period 1975–1998 shows that the general process of international expansion of research activities varied significantly between leading US and European MNCs. It is also clear that the development of the process of globalisation has proceeded unevenly along the five dimensions studied. The data also show the increasing concentration of both US and European research investment in the USA.     

The determinants of pharmaceutical research and development expenditures

Since the late 1970s, pharmaceutical R&D has grown at a rapid rate relative to sales and other variables. In this paper, we examine the determinants of pharmaceutical R&D using a pooled data sample of 11 major drug firms over the period 1974 to 1994. We find that expected returns and cash flows are important explanatory variables of firm research intensities during this period. This is consistent with our results for an earlier sample period characterized by very different growth patterns on R&D.     

The effects of patent-law changes on innovation: The case of India's pharmaceutical industry

Recent patent-law changes in India's pharmaceutical industry provide opportunities to study changes of institutional and regulatory environments on innovation and social welfare in low-income markets. From 1972 to 2004 under its process-patent regime, India's pharmaceutical industry grew to become the world's fourth largest. Indian companies were becoming globally competitive in generics and clinical testing, and moving into product R&D. Researchers have debated the effects of India's new product-patent laws' effects on these trends. The authors cover the domestic characteristics and global competitiveness of India's pharmaceutical industry. They contrast data (from 2001 to 2004) on patents in India's process-patent regime with preliminary data (from 2005 to 2008) on patents in the country's new product-patent regime. They argue that Indian pharmaceutical companies have changed their decision-making in response to changed patent laws by moving from process to product research. However, the preliminary results indicate that these changes may have hurt domestic innovation. They conclude with strategic implications for the Indian pharmaceutical industry and highlight the need for research and public policy to establish optimal social returns from product-patent regimes.     

Telecommuting : The case of research software development

This paper reports seven case histories involving the use of telecommuting in the environment of research software development over a 15-year period. The cases are presented and analyzed, and their normative implications are explored. These cases indicate three trends. First, remoteexpertise will become increasingly valuable and easy to obtain. Second, face-to-face contact will remain important and should be anticipated. It is necessary for ill-defined tasks, for group identity, and for general demonstration of judgement, ability, and competence. Third, telecommuting will become an ordinary, though augmentative, component of work involving highly motivated, independent knowledge workers with well-developed social skills. Such work will be loosely coupled and less hierarchical.     

Introduction: globalisation,governance and development

In 1887 Henry Carter Adams produced a study demonstrating that the ownership of government bonds was heavily concentrated in the hands of a ‘bondholding class’ that lent to and, in Adams's view, controlled the government like dominant shareholders control a corporation. The interests of this bondholding class clashed with the interests of the masses, whose burdensome taxes financed the interest payments on government bonds. Since the late nineteenth century there has been plenty of debate about the ownership of the public debt. But the empirical evidence offered to support the various arguments has been scant. As a result, political economists have few answers to questions first raised by Adams over century ago: how has the pattern of public debt ownership changed? Can we still speak of a powerful ‘bondholding class’? Does public debt redistribute income from taxpayers to public creditors? This article develops a new framework to address these questions. Anchored within a ‘capital as power’ approach, the research indicates a staggering pattern of concentration in the ownership of US public debt in the hands of the top one per cent of US households over the past three decades. Accordingly, the bondholding class is still alive and well in contemporary US capitalism.     

Industrial development in the inland region of China: A case study of the motorcycle industry

Although the inland region of China has generally been left behind in economic development compared with the coastal region, the motorcycle industry in Chongqing has recorded remarkable growth due to the meteoric rise of private enterprises over the last decade. Based on panel data of enterprises, we attempt to identify the factors behind the dynamic development of this industry. We conclude that the success of the motorcycle industry in Chongqing is attributable to a combination of positive features from the Wenzhou model in the 1990s, in which industrial development is based on clustering of private enterprises, and the Sunan model in the 1980s, in which industrial development is based on the effective use of human resources recruited from existing state-owned enterprises (SOEs). Learning by collective enterprises from SOEs in Chongqing coupled with the growth of the private enterprise sector fostered cluster-based industrial development. Journal of Comparative Economics 34 (4) (2006) 818–838.     

行业“金字塔结构”假设及验证——以医药、食品行业为例

医药、食品行业是与百姓生活息息相关的两个行业。然而,目前两个行业在我国的发展现状都不容乐观。本文试图透过现象看本质,探究隐藏在这些产业组织问题背后的逻辑。在借鉴SGP范式分析的基础上,分析了行业内企业规模结构,提出了行业金字塔结构的假设,指出了企业规模结构上存在的特点及其对企业行为以及产业绩效的影响。本文还利用笔者调研所得到的数据对模型进行了初步验证,并针对如何提升产业竞争力提出了若干建议。     

The pharmaceutical industry: Towards a new innovation environment

This article examines one facet of changing research alliances between the private and public sector. Consideration ofthe changes occurring within the pharmaceutical industry as a whole and its approach to research and development (R&D) give us some indight into why pharmaceutical companies are are zncreasingly choosing to embark on long-term R&D collaborations with hzgher education establishments. The article suggests possible future directions of alliances and raises questions regarding the implications for industrial and academic research departments izs a result of such collaborations.     

Endogenous innovations in the pharmaceutical industry

This paper addresses the creation of new products in the US pharmaceutical sector, during the second half of the 20th century. We indicate that the continuous increases in population, and thus in the market size of this sector, play a fundamental role in explaining the large creation of new drugs during that period. We also argue that population and market size can be endogenously determined through the impact of drugs over the mortality rate. Hence, these two effects reinforce each other, producing decrements in the mortality rate and increments in the stock of drugs over time. We obtained the set of new molecular entities approved by the FDA during the second half of the 20th century and we decomposed the data in a panel of 15 therapeutic categories over time. Using this data, we tested our hypotheses using different econometric methods. The results support the hypothesis and are consistent across methods.

Patent term extensions and commercialization lags in the pharmaceutical industry: A growth-theoretic analysis

Due to the lags in commercialization, the effective life of a patent is generally less than its statutory term. We introduce commercialization lags into the Schumpeterian growth model and explore the effects of patent term extensions on pharmaceutical R&D and social welfare. Our results show that extending patent terms stimulates the consumption of homogeneous goods but generates an ambiguous effect on the consumption of pharmaceuticals. When patent extensions have an inverted-U effect on social welfare, the optimal patent extension increases with the length of commercialization lags but decreases with the input intensity of commercialization lags. Finally, we calibrate the model and find that increasing patent breadth reduces the optimal patent extension.     

Positioning and negotiations: The case of pharmaceutical pricing

We study a positioning game prior to negotiations where each party invests into influential activities in order to raise voter support for their preferred bargaining outcome. The case chosen for our analysis is a bilateral monopoly where a purchaser meets a pharmaceutical firm and where the two negotiate on the price of a new and innovative medicine. We identify factors that influence on the negotiated price such as treatment effects of the new and the existing drug, production costs of the new drug, the price of the existing drug, the marginal cost of public funds and patient group size. Furthermore, it is shown that the negotiated price, depending on the characteristics of a political cost function with regard to the influential activities, is influenced by the order of moves taken by the parties. Regardless of the strategic interrelationships between the two parties, likely positioning games to be played are those where one of the two negotiating parties acts as a leader while the rival acts as a follower.     

Technological change and industry structure: A case study of the petroleum industry

This paper is a case study of the impact of an exogenous improvement of a process technology on the structure of the petroleum industry. The paper examines the role of three-dimensional seismology in bringing about the 1990s oil industry consolidation. This proposition is examined in the context of evolutionary economics and in a non-cooperative game theory, concluding with a reference to Steindl's theory of industry dynamics. The significance of this contribution lies chiefly in highlighting the fact that exogenous technological change can, under appropriate conditions, play a significant role in industry dynamics. This reference to the exogenous change in technology is a departure from the traditional consideration of endogenity of industry structure in relation to technological development and, therefore, a novelty. Secondly, the documentation of 3D seismology as a significant process technology of the petroleum industry is significant.     

The healthy development of economies: A strategic framework for competitiveness in the health industry

Applying a strategic decision-making perspective on the economics of business, we suggest that a competitive locality in the health industry is one that, relative to other localities, is effective in: (1) providing the healthcare that enables everyone to participate fully in the democratic development of the locality; (2) providing the healthcare that is democratically identified as a direct objective of this development; (3) contributing through the health industry to any other democratically determined objectives of the locality's development. The paper hypothesizes that strategic decision-making in organizations is an especially significant determinant of the impacts of the health industry. We conclude that: (i) a locality that suffers concentration in the power to determine the objectives of its health industry could not be strictly competitive in that industry; (ii) the first best way to achieve competitiveness in the health industry would be to democratize its strategic decision-making. What this would entail in practice is discussed in some detail.     

Government intervention in industry: The case of Israel

Industrial activity in Israel is marked by considerable government intervention, especially in the capital market. This paper examines its effect on rates of return, risk, exports, and the structure of industry (concentration and firm size). The results (1965–1980) show that risk (whose main element is the probability of bankruptcy), R&D spending and human capital were positively related to the rate of return; the effect of firm size and concentration was negative, an unexpected result reflecting mainly government support generating excess investment and unutilized capital. Although most industries in Israel are private and competitive government measures had a substantial, mostly indirect, negative effect on the determinants of industrial performance.     

Peace parks: The paradox of globalisation1

Concern for environmental protection within an increasingly ‘globalised’ international system has led in many parts of the world to plans for transfrontier conservation areas, commonly known as ‘Peace Parks’. These offer the prospect of providing integrated management for bioregions that have been divided by state frontiers, and reopening animal migration routes. They also promise increased tourist revenues since visitors, too, would be free to benefit from the enhanced transnational space that the parks provide. This paper examines plans for such parks in two regions, Southern Africa and Central America. In practice, these plans have been undermined by the existing uses of transnational space for informal (and often criminal) transfers that themselves benefit from the permeability of frontiers in areas that are weakly controlled by state authorities; these include smuggling, poaching, illegal immigration and the trade in narcotics. Such activities, which likewise derive from ‘globalisation’, generate powerful political interests, both among local communities and more widely. Paradoxically, the creation of Peace Parks requires more, and not less, state control of frontier zones, and raises significant issues for the management or control of globalising forces in weakly administered regions of the developing world.     

The relationship between a firm's patent quality and its market value — The case of US pharmaceutical industry

This study examined the relationships between corporate market value and four patent quality indicators - relative patent position (RPP), revealed technology advantage (RTA), Herfindahl-Hirschman Index of patents (HHI of patents), and patent citations - in the US pharmaceutical industry. The results showed that RPP and patent citations were positively associated with corporate market value, but HHI of patents was negatively associated with it, while RTA was not significantly related to it. Thus, if pharmaceutical companies want to enhance their market value, they should increase their leading positions in their most important technological fields, cultivate more diversity of technological capabilities, and raise innovative value of their patents. In addition, this study found that market value of pharmaceutical companies with high patent counts was higher than that of pharmaceutical companies with low patent counts, and suggested that pharmaceutical companies with low patent counts should increase RPP in their most technological fields, decrease HHI of patents, or raise patent citations to further enhance their market value. Furthermore, this study developed a classification for the pharmaceutical companies to divide them into four types, and provided some suggestions to them.     

The determinants of efficiency: the case of the Spanish industry

The aim of this paper is to analyse the factors explaining the technical efficiency of Spanish industrial sectors during the period 1991–1994 using the Survey of Business Strategies (SBE) of the Ministry of Industry and Energy. It analyses whether efficiency can be explained by factors external to the firm such as the degree of competition in the markets in which it operates, characteristics of the firm (size, organization, advantages of location, participation of public capital, etc.), as well as the effects of dynamic disturbances that may affect the degree of utilization of the productive capacity.