Research Strategies in Science-based Start-ups: Effects on Performance in Danish and Swedish Biotechnology

Although biotech start-ups fail or succeed based on their research, few attempts have been made to examine if and how they strategise in this core activity. Using a unique comprehensive dataset on Danish and Swedish biotech start-ups in drug discovery this paper adopts a Simonean approach to analysing the research strategies of small dedicated biotech firms (DBFs), focusing on three interrelated issues: (i) characterising the problem architectures addressed by different types of DBFs; (ii) testing and confirming that DBFs form requisite research strategies, by which we refer to problem-solving approaches developed as congruent responses to problem architectures; and (iii) testing and confirming that financial valuation of firms is driven by achievements conforming to requisite research strategies. These strategies, in turn, require a careful combination of multiple dimensions of research. The findings demonstrate that Schoonhoven's argument that 'strategy matters' is valid not only for the larger high-tech firms covered by her study, but also for small research-based start-ups operating at the very well-springs of knowledge where science directly interacts with technologies. Although more research is needed along these lines, these findings offer new implications for the understanding, management and financing of these firms.     

R&D contribution in TFP growth of Greek industry: A limited information likelihood approach

We provide a novel panel model to decompose total factor productivity (TFP) growth in the Greek industry at the firm level while we tackle the contribution of R&D. We, therefore, opt for parametric methodology that provides statistical inference and would validate the results. Our modeling departs from prior strong assumptions such as error terms across firms being independent. In fact, we provide a novel limited information maximum likelihood (LIML) estimation method that adequately deals with the issue of endogeneity and model misspecification. We demonstrate that our model detects variability in terms of TFP growth components across industries and firms. Our results show that R&D would enhance TFP of Greek firms, albeit the crisis has had a detrimental impact. Financial ratios such as liquidity and solvency ratios also affect TFP as we demonstrate that both would enhance TFP. The solvency ratio is important as it provides an estimate of whether the firm can cope with debt. We also note variability across small versus medium and large firms and report that small firms are more productive and spend more of their revenues on R&D. In terms of policy, our evidence warrants higher R&D spending to enhance TFP growth, though R&D funding is a concern.     

Assessing the returns to collaborative research: Firm-level evidence from Italy

We use firm-level data from Italian manufacturing firms to assess the relationship between various types of R&D and total factor productivity growth, including collaborative research with other firms and universities. A novel twist to our empirical analysis is that we estimate a sample selection model, which allows us to treat the decision to conduct R&D as endogenous. We find strong evidence of positive returns to collaborative research with other companies, whereas collaborative research with universities does not appear to enhance productivity. This result implies that firms may conduct R&D with universities when appropriability conditions are weak and the outcomes of such research projects do not yield direct strategic benefits.     

A dynamic model of R&D competition

This study considers a dynamic model of R&D competition in a situation of no uncertainty with identical firms in a perfect foresight. We are going to find out about the effects of firms' absorptive capacity on R&D strategies in the presence of technological spillovers. The conditions for the existence and uniqueness of a feedback–Nash equilibrium on firms' R&D expense will be also discussed. Numerical simulations will show as the introduction of the absorptive capacity reduces the impact of spillovers degree on firms' R&D strategies.     

R&D expenditures and firm growth – is small beautiful?

ABSTRACT

This paper examines how efficiently different groups of firms use their R&D expenditures. To this end, it investigates how the empirical relationship between firms' R&D expenditures and their sales growth varies with different values of firm size, firm age, and the number of firms in the respective industry. Using panel data for Switzerland ranging from 1995 to 2012, the paper finds that smaller, more mature firms show a more positive relation between R&D expenditures and sales growth than both relatively larger or younger firms. The paper argues that, on the one hand, these firms can benefit from various small size advantages in the R&D process, such as more motivated researchers, caused by a stronger connection to the firm's fate. On the other hand, these firms can also benefit from a well-established R&D department that allows absorbing the latest technological developments. The paper further finds that industries consisting of many small firms show a more positive relation between R&D expenditures and sales growth than industries consisting of only a few large firms. The intuition behind this result is that industries consisting of many small firms imply more independent innovative trials, which then together result in a higher probability of discovering successful innovations. In sum, the paper finds that groups consisting of a large number of small, more mature firms spend their R&D in the most efficient way.     

How to promote R&D-based growth? Public education expenditure on scientists and engineers versus R&D subsidies

This paper compares the positive and normative implications of two alternative measures to promote R&D-based growth: R&D subsidies to firms and publicly provided education targeted to the development of science and engineering (S&E) skills. The model accounts for the specificity of S&E skills, where individuals with heterogeneous ability choose their type of education. Although intertemporal knowledge spillovers are the only R&D externality, the analysis suggests that R&D subsidies may be detrimental to both productivity growth and welfare. Moreover, they raise earnings inequality. In contrast to R&D subsidies, publicly provided education targeted to S&E skills are found to be unambiguously growth-promoting and neutral with respect to the earnings distribution.     

Dismantling the ivory tower: The influence of networks on innovative output in emerging technologies

In this article we examine how R&D networking affects an organization's innovative output. Using empirical data on 419 research organizations in transgene plant research over a 20-year period, we test several hypotheses relating their sociometric position in an R&D network to their innovative output. Attention is paid to the relative importance of in-house versus collaborative research. Least squares dummy variable models are used to analyze cross-sectional data across different time periods. The results show that (1) an organization's “network embeddedness” positively influences its innovative output; whereas (2) involvement in collaborative R&D has a curvilinear effect on innovative performance.     

A practical approach to R&D project selection

We present a technique to allocate available resources more systematically to competing R&D projects in a government laboratory setting. The technique is simpler than most models described in the literature, systematically utilizes the expertise of various organizational units in the corporation, and does not try to substitute complex calculations for good managerial judgment. The literature on R&D project selection models is briefly reviewed. Key factors identified are used to develop the approach. Details are presented on the sequence of the R&D project selection process through alternative levels of corporate management. Sample forms used for R&D ideas submittal and evaluation are included. Experiences gained from applying the approach in a large R&D laboratory are discussed.     

Firm size and types of innovation

We propose a general theory of innovation that illustrates the relative benefits of performing process versus product R&D when firm size is endogenous. A firm's size, scope, and R&D portfolio are shown to reflect the same underlying characteristic of the firm, namely manufacturing efficiency. We demonstrate that efficient firms become larger, have greater scope, and perform more of both process and product R&D. In light of decreasing returns to R&D, this implies small firms obtain more product innovations per dollar of R&D than large firms, which is consistent with evidence we present that small firms are more innovative than large firms as they obtain more patent counts and citations per dollar of R&D.     

The 1988 EC directive on biotechnological inventions and the UK biotechnology industry

The article, based on a recent survey of UK biotechnology companies, highlights the complex interaction between the organization of R&D and the patenting policy in the biotech industry. Some of the more interesting findings include: the limited extent of private investment in biotechnological R&D; the existence of two markedly different R&D strategies (product- vs. process-based); the distinction between first- and second-generation patents and their effects on market structure. The core of the article deals with the likely effects on patenting behaviour of changes in patent law - both as envisaged in the October 1988 Directive and as suggested by recent theoretical research on the economics of patents. The Directive in its current form is reported to have no discernible effect on the extent and organization of R&D, whereas the industry's response to a series of hypothetical changes suggests that any definition or patentability standards has far-reaching repercussions on: (1) the allocation of resources between research and development; (2) the conditions of entry into the industry; (3) the balance of bargaining power between firms of unequal size (or pursuing different R&D strategies); and ultimately (4) the allocation of technological surplus between consumers and producers.     

Composition of R&D expenditures and firm performance

ABSTRACT

The explosion of research and development (R&D) expenditures in China brings a puzzling fact that the proportion of research in R&D is extremely small, and thus the proportion of development is large. This article distinguishes research from development in R&D and investigates the heterogeneous effects of the two components on the performance of Chinese listed firms. Using a generalized propensity score matching approach with continuous treatments, we present non-linear relationships between R&D composition and firm performance. While development-oriented firms benefit more from an increase in profit than a growth in productivity, orientation toward research contributes more to productivity gains than to profitability. Research and development activities are found to be complementary in promoting firm performance. The results suggest the existence of optimal proportions of the components of R&D for maximizing firm performance.     

Using resources in R&D policy planning: Brazil, the Amazon and biotechnology

Brazil's research and development (R&D) policies are examined in light of changes in economic direction especially as it pertains to competition. In a competitive environment, regions should develop industrial applications and expertise in areas that coincide with their resources. These could be human resources but could, as in the focus of this paper, be useful resources that differentiate the region from others in the world. This differentiation provides an advantage to the region. Brazil and its Amazon region has the large majority of the world's rare genes. In biotechnology, genes are “green gold,” and Brazil is slowly developing a biotechnology industry and beginning to tap into the Brazilian Amazon region's economic biotech potential. This region has enormous potential for the development of biotech-related technologies and products. This paper discusses the relationship between resources and an R&D strategy using as an example the recent developments in biotechnology research in Brazil and the role of the Amazon region in the development of a Brazilian biotechnology industry. It recommends a number of policy initiatives that will enhance Brazil's focus on biotechnology.     

Innovative growth: the role of market power and negative selection

ABSTRACT

This paper relies on register-based statistical data from Finland to measure broad research and development (R&D), organizational capital (OC) and information and communication technology (ICT) investments as innovation inputs in addition to formal survey-based R&D and CIS survey data on innovations. The linked panel data are appropriate for a comparison of low-market-share (small) and large-market-share (large) firms. We analyze the productivity growth and profitability of Finnish firms with varying market power. In contrast to high-market-share firms, low-market-share firms are characterized by low profit derived from new innovations. This study suggests that in addition to imitative growth, a ‘negative selection mechanism’ explains the high productivity growth relative to the low profits.     

Employment growth and innovation at the firm level

We analyze the influence of innovation on growth rates of employment in 859 Dutch manufacturing firms over the period 1983–1988. Whereas the (growth of the) R&D intensity of firms has a slightly negative impact on employment, we find that firms with a high share of product-related R&D (as a proxi of R&D related to industrial activities in an early stage of the life cycle) experienced an above average growth of employment. The same holds for firms which directed their R&D towards information technology. Smaller firms have, ceteris paribus, substantially higher growth rates of employment than their larger counterparts. Against our expectations, R&D cooperation has no significant impact on employment growth. The same holds for activities in the fields of biotechnology and new materials.     

R&D subsidies in a model of growth with dynamic market structure

This paper presents the effects of an R&D subsidy in a Schumpeterian general equilibrium model with rich industry dynamics. R&D subsidies raise the long-run growth rate, but they also raise the level of industry concentration. In the model firms compete for market share through process R&D endogenously determining the market structure within and across industries. Endogeneity of the market structure allows for analysis of changes in the moments of the firm size distribution in response to policy. R&D subsidies primarily benefit large incumbent firms who increase their innovation rates creating a greater technological barrier to entry. Concentration increases with fewer firms and a higher variance in the market shares. In general equilibrium, the greater distortions in the product market cause the wage rate to fall which leads to increased turnover rates. In addition, the analysis demonstrates that the model captures a large number of empirical regularities described in the industrial organization literature, but absent from most endogenous growth models. These features, such as entering firms are small relative to incumbents, the hazard rate of exit is negatively related to firm size, and large firms spend more on R&D than small firms play important roles in understanding the impact of R&D subsidies on the economy.     

Research technology organisations as leaders of R&D collaboration with SMEs: role,barriers and facilitators

Research technology organisations or RTOs have attracted academic interest in the last decade due to their role as technology transfer agents and R&D collaborative leaders for firms and especially for small and medium enterprises (SMEs). Although their role within the diversity of specialised structures in generating R&D for industry in National Innovation Systems is recognised, there are scarce publications in relation to their strategies, performance or characteristic, as leaders of R&D collaboration with SMEs. The aim of this work is to identify the role, barriers and facilitators for RTOs performance as well as to develop a contingency relationship between industry environment, strategy, organisational structure and other factors for successful technology transfer from technology organisations to SMEs. This research is based on a field study conducted on 14 technology organisations based in the Valencia region, working with various industry sectors.     

R&D and productivity growth: Evidence from the UK

Although the econometric evaluation of R&D has attracted wide interest in many countries, it has not attracted much in the UK. The main objective of this paper is to fill this void, i.e., to estimate the impact of R&D on productivity growth of the UK manufacturing sector. However, there are some additional objectives. Firstly, we estimate the impact of R&D on productivity growth of large and small firms and we discuss a number of theoretical arguments regarding the role of firm size. Secondly, given that the technological infrastructure influences the innovative capacity of a firm, we compare the impact of R&D on productivity growth of high-tech firms with the corresponding impact on productivity growth of low-tech firms. Thirdly, we investigate whether the contribution of R&D to productivity growth has changed over time.

Based on firm-level data (78 firms, 1989–2002), we find that the contribution of R&D is approximately 0.04. Although the R&D-elasticity of large firms (0.044) is higher than the corresponding elasticity of small firms (0.035), the difference is small. In contrast, the R&D-elasticity is considerably high for high-tech sectors (0.11), but statistically insignificant for low-tech sectors. Finally, the investigation of the elasticity of R&D over time revealed an interesting discontinuity showing that although until 1995 the R&D-elasticity was approximately zero, after 1995 it increased dramatically to 0.09. We investigate the potential causes of such non-linearity and we suggest a number of possible explanations.     

International R&D Networks

This paper considers the Goyal and Moraga‐Gonzalez (2001 ) model of strategic R&D collaboration networks in the open economy framework. The R&D is the d'Aspremont and Jacquemin (1988 ) process innovation and collaboration takes the form of research joint ventures (RJV) in which firms cooperate in R&D but compete in product markets. Countries decide whether to establish free‐trade links while firms decide whether and with whom to form RJVs. A double‐layer pairwise stability concept is introduced to characterize equilibrium network structures. In contrast with conventional wisdom, it is shown that global free trade generally reduces collaborative R&D levels. We give conditions for which pairwise stable R&D networks are welfare maximizing. Stability and efficiency are congruent when R&D cost is either too high or too low. A large public spillover effect is detrimental to an R&D network when trade networks are regional.     

Welfare and growth impacts of innovation policies in a small, open economy; an applied general equilibrium analysis

We explore how innovation incentives in a small, open economy should be designed in order to achieve the highest welfare and growth. The computable general equilibrium model we develop for the purpose allows for research and development (R&D)-driven endogenous technological change embodied in varieties of capital. We study policy alternatives targeted towards R&D, capital varieties formation, and domestic investments in capital varieties. Subsidising domestic investments, thereby excluding stimuli to world market deliveries, generates less R&D, capital formation, economic growth, and welfare than do the other alternatives, reflecting that the domestic market for capital varieties is limited. In spite of breeding stronger economic growth, a higher number of patents, and a higher share of R&D in total production, direct R&D support generates slightly less welfare than subsidising formation of capital varieties. The costs in terms of welfare relates to a lower production within each variety firm, which in presence of mark-up pricing results in efficiency losses.     

Analysis of the Interaction between Regional R&D Productivity and the Investment Strategies of Multinational Enterprises

The aim of this article is to analyze the interaction between regional R&D productivity and the investment strategies of multinational enterprises. The discussion is based on the hypothesis that R&D investments cause a reduction in the production costs and an increase in firms’ market share; furthermore, R&D costs may be affected by national industrial policies. Supposing the existence of asymmetries in local research productivity, necessary and sufficient conditions for a geographical diversification of resources have been found. Suggestions with respect to the optimal allocation of R&D investment are finally derived.