Innovation forecasting

Technological forecasting is premised on a certain orderliness of the innovation process. Myriad studies of technological substitution, diffusion, and transfer processes have yielded conceptual models of what matters for successful innovation, but most technological forecasts key on limited empirical measures quite divorced from those innovation process models. We glean a number of concepts from various innovation models, then present an array of bibliometric measures that offer the promise of operationalizing these concepts. Judicious combination of such bibliometrics with other forms of evidence offers an enriched form of technological forecasting we call “innovation forecasting.” This provides a good means to combine technological trends, mapping of technological interdependencies, and competitive intelligence to produce a viable forecast. We illustrate by assessing prospects for ceramic engine technologies.     

Interactive visualization of 3D mantle convection

The current availability of thousands of processors at many high performance computing centers has made it feasible to carry out, in near real time, interactive visualization of 3D mantle convection temperature fields, using grid configurations having 10–100 million unknowns. We will describe the technical details involved in carrying out this endeavor, using the facilities available at the Laboratory of Computational Science and Engineering (LCSE) at the University of Minnesota. These technical details involve the modification of a parallel mantle convection program, ACuTEMan; the usage of client–server socket based programs to transfer upwards of a terabyte of time series scientific model data using a local network; a rendering system containing multiple nodes; a high resolution PowerWall display, and the interactive visualization software, DSCVR. We have found that working in an interactive visualizastion mode allows for fast and efficient analysis of mantle convection results.     

Asymmetric Oligopoly and Foreign Direct Investment: Implications for Host-Country Tax-Setting

We present a duopoly model with heterogeneous firms that vary in cost-efficiency, each of which can choose to serve a foreign market by either exporting or local production. We do so to analyse the effects of a host-country corporate profit tax on both the scale and composition of FDI, and find that: strategic interaction between oligopolistic firms provides for a pattern of FDI that favours cost-inefficiency to the detriment of host-country welfare; and the host-country tax rate can be optimally used to avoid such patterns of FDI and instead promote direct investment by a relatively cost-efficient firm.     

Estimating the clinical effectiveness and value-based price range of erenumab for the prevention of migraine in patients with prior treatment failures: a US societal perspective

Background: Frequent migraine with four or more headache days per month is a common, disabling neurovascular disease. From a US societal perspective, this analysis models the clinical efficacy and estimates the value-based price (VBP) for erenumab, a fully human monoclonal antibody that inhibits the calcitonin gene-related peptide receptor.

Methods: A Markov health state transition model was developed to estimate the incremental costs, quality-adjusted life-years (QALYs), and value-based price range for erenumab in migraine prevention. The model comprises “on preventive treatment”, “off preventive treatment”, and “death” health states across a 10-year time horizon. The evaluation compared erenumab to no preventive treatment in episodic and chronic migraine patients that have failed at least one preventive therapy. Therapeutic benefits are based on estimated changes in monthly migraine days (MMD) from erenumab pivotal clinical trials and a network meta-analysis of migraine studies. Utilities were estimated using previously published mapping algorithms. A VBP analysis was performed to identify maximum erenumab annual prices at willingness-to-pay (WTP) thresholds of $100,000–$200,000 per QALY. Estimates of VBP under different scenarios such as choice of different comparators, assumptions around inclusion of placebo effect, and exclusion of work productivity losses were also generated.

Results: Erenumab resulted in incremental QALYs of 0.185 vs supportive care (SC) and estimated cost offsets due to reduced MMD of $8,482 over 10 years, with an average duration of treatment of 2.01 years. The estimated VBP at WTP thresholds of $100,000–$200,000 for erenumab compared to SC ranged from $14,238–$23,998. VBP estimates including the placebo effect and excluding work productivity ranged from $7,445–$13,809; increasing to $12,151–$18,589 with onabotulinumtoxinA as a comparator in chronic migraine.

Conclusion: Erenumab is predicted to reduce migraine-related direct and indirect costs, and increase QALYs compared to SC.     

Patterns of infant mortality in rural England and Wales, 1850–1910†

The study of nineteenth‐century infant mortality in Britain has neglected the rural dimension to a surprising degree. This article maps the change in infant mortality rate (IMR) between the 1850s and the 1900s at registration district (RD) level. Latent trajectory analysis, a longitudinal model‐based clustering method, is used to identify the clusters into which rural RDs fell, based on their IMR trajectories. Relationships between IMR and population density, fertility, female tuberculosis mortality, female illiteracy, male agricultural wages, and distance from London are examined in a longitudinal study. The tuberculosis (maternal health), illiteracy (education), and distance variables had the most effect. IMR responded most strongly to improving health and education in the east, less in the central area, and least in the north and west. The eastern zone's higher‐than‐average mid‐century infant mortality therefore declined faster than the national average. A central and southern zone had slightly lower IMR in mid‐century but did not keep up with the rate of decline in the east. The peripheral north and west had the lowest mid‐century rates but their decline was overtaken by the other zones. The interpretation of these findings and their relevance to the wider study of infant mortality are discussed.     

Corporate Charitable Giving, Multinational Companies and Countries of Concern

This paper investigates the degree to which corporate charitable giving is influenced by a firm's internationalization and/or whether it has operations in one or more countries of concern. For a sample of large UK firms, we find evidence of a positive effect not for internationalization per se, but only for a presence in particular countries. In this connection, the salient country characteristic is a lack of political rights and/or civil liberties, and the positive impact on charitable giving is restricted to a presence in only those countries that are, according to Freedom House indicators, most lacking in this respect. Furthermore, our study highlights a mode of corporate response to stakeholder concerns and pressures – offsetting – that is qualitatively different from those suggested in earlier conceptual literatures.     

Building trust in US-Japanese business relationships: Mediating role of cultural sensitivity

While evidence suggests trust plays a fundamental role in maintaining successful buyer-seller relationships in Japan, little is known conceptually as to how foreign sellers can best develop trust in the minds of their Japanese customers. In this research, we develop and test a multi-component model of US seller actions that manifest key trust-building processes (intentionality- and capability-processes) which sellers find effective in building trust with their Japanese buyers. In this unique cultural context, theory suggests trust develops when sellers demonstrate benevolent intentions toward the buyer and exhibit a strong capability to fulfill business promises. An analysis of 181 US sellers in Japan demonstrates that a combination of trust-building efforts is recognized as being critical in seller attempts to develop and sustain trust on the part of their Japanese customers. Importantly, cultural sensitivity mediates the impact of intentionality-based practices on buyer trust, while capability-based activities directly influence trust.     

Effects of microcredit and other loans on female empowerment in Bangladesh: the borrower's gender influences intra‐household resource allocation

This article examines microcredit's effectiveness in empowering women borrowers in rural Bangladesh. It does so by examining how gender‐specific borrowing activities influence household expenditures which are either specifically of interest to men or women, and by examining the effects of all loans rather than only those provided by microcredit organizations. The article uses a quasi‐experimental design to identify the effects of borrowing by men and women by using an original combination of panel data and instrumental variables on subsamples of the surveyed population. It finds that the borrower's gender affects how households allocate their resources to different expenditure items and assets that are valued differently by men and women. In all, the findings suggest that providing greater credit access to women may improve their household bargaining positions.