Rivaroxaban for non-valvular atrial fibrillation and venous thromboembolism in the Netherlands: a real-world data based cost-effectiveness analysis

Background: Non-vitamin K antagonist oral anticoagulants (NOACs) have been included in international guidelines as important alternatives to vitamin K antagonists (VKAs) for the treatment of venous thromboembolism (VTE) and stroke prevention in non-valvular atrial fibrillation (NVAF). Meanwhile, in the Netherlands, NOACs are widely used next to VKAs. The objective of this study is to estimate the cost-effectiveness of treatment with rivaroxaban compared to VKAs in NVAF and VTE patients in the Netherlands, using data from international prospective observational phase IV studies.

Methods: Two models were developed to represent NVAF and VTE patients, populated with patients from the XANTUS (NCT01606995) and XALIA (NCT01619007) international prospective observational studies. The 1-year cost-effectiveness of rivaroxaban use, compared to VKAs, was explored in a population consisting of NVAF and VTE patients (base case) as well as for four scenarios with sub-populations: NVAF patients only, VTE patients only, NVAF patients with unstable international normalized ratio (INR), and NVAF patients using an INR self-measuring device.

Results: In the base case, rivaroxaban saved €72,350 and gained 21 quality-adjusted life-years (QALYs) in a simulation of 2,000 patients over the use of VKAs. Ergo, rivaroxaban was dominant over VKAs. The probabilistic sensitivity analysis showed a probability of 85% for rivaroxaban being dominant and 100% at a willingness-to-pay threshold of €20,000/QALY. Rivaroxaban appeared to be dominant in all scenarios as well, except for the NVAF-patients-only scenario where the incremental cost-effectiveness ratio (ICER) was €157/QALY.

Conclusions: In patients with NVAF or VTE, rivaroxaban treatment is likely to be cost-effective and a potentially cost-saving alternative to VKA in the Netherlands.     

重叠滤波多音系统的频偏性能分析及优化

重叠滤波多音(O-FMT)是针对滤波多音(FMT)系统频谱利用率低的缺点而根据超奈奎斯特(FTN)概念引入子载波重叠得到的方案。鉴于O-FMT系统在频偏环境下的性能缺陷，理论分析了频偏对系统信号各部分的影响，比较了O-FMT与正交频分复用（OFDM）系统的抗频偏性能。针对频偏性能优化问题，提出了基于最佳线性无偏估计（BLUE）的改进盲估计算法，设计了基于频域滤波器系数的内嵌结构进行频偏补偿。仿真实验表明，O-FMT相比OFDM具有更好的抗频偏能力，改进的盲估计算法估计值精度更高，抗干扰、抗衰落能力更强，设计的频偏补偿结构可以使系统获得更好的性能。     

基于BDS的ADS-B报文生成系统

目前国际民航组织（ICAO）和美国航空无线电技术委员会（RTCA）有关广播式自动相关监视（ADS-B）标准中的报文数据源均规定来自全球定位系统（GPS），而中国自主建设的“北斗”卫星导航系统（BDS）作为ADS-B数据源是必然趋势。设计了基于BDS的ADS-B报文生成系统的总体架构，利用BDS接收机接收的真实数据仿真生成了ADS-B的6种报文，并以空中位置报文的生成为例，详细阐述了报文产生涉及的关键技术以及报文的生成过程。通过运行集成后的ADS-B报文生成系统以及对所产生的6种报文的仿真验证，证明该系统总体设计思路合理，运行结果正确，可为基于BDS的ADS-B相关技术研究提供稳定可靠的ADS-B报文源。     

较差质量数据下的返回弹道计算及对落点影响的分析

针对某老式卫星返回时雷达跟踪数据曾发生的测量异常及质量较差等情况，为解决此类数据在返回弹道及落点计算中出现的实际困难以及给出应对措施，基于工程实际情况给出了三种不同建模类型下的弹道计算方法——当前统计解耦扩展卡尔曼滤波（EKF）、动力学建模无迹卡尔曼滤波（UKF）、多项式滑窗最小二乘估计算法，并应用该次质量较差的实际观测数据进行了算法应用效果分析与落点计算情况对比，对计算中的经验及教训进行了总结。研究结果表明，所给出的三种算法在面对较差质量数据时性能差异较大，在工程实际应用中可考虑将多种算法互为参考。研究结果及其经验教训对卫星返回弹道及落点的实时估计的工程实施有一定的参考价值。     

基于改进指纹聚类的WLAN定位优化方法

将K-means聚类算法应用到无线局域网（WLAN）位置指纹定位中，虽然可以缩短定位时间，但是容易降低定位精度。为了解决此问题，提出了基于改进指纹聚类的WLAN定位优化方法。首先根据接收信号强度标准差来优化初始聚类中心的选取,然后对指纹数据进行聚类处理,最后进行在线定位。实验结果表明，与传统的WLAN位置指纹定位方法和K-means聚类定位方法相比，基于改进指纹聚类的定位优化方法不仅缩短了定位时间，还能有效提高定位精度。     

The Distributional and Allocative Impacts of Virtual Labor Mobility across Time Zones through Communication Networks

Using a specific‐factors' model, with two goods (a shift‐working good and a non‐shift‐working good), three factors (capital specific to shift‐working, land specific to non‐shift‐working and labor) and two countries (Home and Foreign), which are located in different time zones, we highlight the impact of trade in labor services via communication networks on factor prices and production patterns. If two countries are identical in size, then under free trade in labor services, all workers work only in their local daytime, and night shift in each country is performed by imported labor services supplied by residents of the other country in their local daytime. Night‐time wage becomes the same as daytime wage (a wage equalization result). Other factor prices are also equalized. In both countries, capital rental rate increases, while land rent decreases. However, if two countries are different in size, trade in labor services does not equalize wages: in the large country, wages for night‐shift workers are higher than daytime wages and some residents work at night; in the small country, daytime wages become higher than night‐time wages and no one works at night, and night‐shift work is done by imported labor services from the large country. Land rent in the small country decreases. Land rent in the large country may or may not decrease, but it is always higher than in the small country. Capital rental rates in both countries are equalized and increase.     

Knowledge management through the development of knowledge repositories: towards work degradation

This paper questions the consequences of the use of electronic knowledge repositories for work and employment. Drawing on critical research suggesting that knowledge management associated with such tools presents similarities to scientific management principles, it proposes to examine the following key research question: how do employees experience the transformation of the employment relationship when a knowledge repository is introduced to the workplace? The inquiry is grounded in an exploratory qualitative case study of a knowledge management system designed to foster knowledge‐sharing in a Belgian public administration. The findings illustrate two complementary outcomes: this system resulted in employees experiencing deskilling and work degradation, and was met with resistance. Significantly, this paper considers work degradation as a reflexive phenomenon in the context studied, where knowledge‐sharing systems produced deskilling and resistance as part of a specific re‐regulation process.     

我国出租车牌照拍卖机制研究

论文以有效分配、促进竞争、实现经济价值为目标，建立了公开升价拍卖+密封拍卖的两阶段牌照拍卖模型，证明了其有效性和最优性。并以北京市为例讨论了牌照数量的确定、进入密封拍卖阶段的时机和牌照的流通等实际问题。这些讨论将有利于拍卖机制在现实中的操作实施。     

一种改进的CPFSK信号频率估计方法

针对突发信号解调中多普勒频偏大的问题，提出了一种改进的连续相位移频键控信号(CPFSK)频率估计方法。首先接收信号平方运算使信号的调制指数加倍，再通过一次离散傅里叶变换(DFT)，用搜索信号平方谱谱峰的方法实现突发信号频率估计。仿真实验表明，在低信噪比条件下，该算法的频率估计精度比经典的相位差频率估计算法提高了20%；该算法与广泛用于高动态突发信号的频率插值估计算法相比，同道干扰信道下信干比改善可达4 dB，DFT长度缩短约1/3。