Strategies of biotechnology companies

To identfy the R&D and marketing strategies adopted by by biotechnology firms in the UK, a survey was conducted spanning a range of biotechnology firm size, product, organizational arrangemens. and prior experiences with advanced technology. This was done using a comprehensive questionnaire similar to that used in a comparable investigation in the USA. Twenty-three firms active principally engaged in speciality chemicals human diagnostics and agricultural products.The information from the questionnaires was used to analyse the company strategies under three man headings. These were technology acquisitation,marketing and R&D. Companies were charecterized into three clusters within each of these headings. The means of appropriation for different strategies were then examined although the significance of the results was undermined by the small size. Finally, the relationship between R&D and marketing strategies within the same firms was investigated.     

The development of networks between engineering contractors and their clients: the special case of partnering

This paper sets out to show how partnering arrangements between engineering contractors in process plant contracting and their process industry clients have led to increasing collaborative contributions at the 'front end' of capital asset formation. Partnering arrangements are seen here as formalised long-term contracts between process plant contractors and their clients, intended to apply to engineering and other services in major capital projects over a number of years.
While research does not appear to have been affected to a significant extent, partners seem to be interacting increasingly on process development and design. One outcome of partnering is to increase the contractors' involvement in their clients' overall business objectives. As a result of this change in the character of their services, contractors are more inclined to seek opportunities to improve plant efficiency, rather than following given specifications. This interaction of entities with a different focus and, to some extent, different skills is a potential source of innovation which to date has not been realised to any great extent.     

Quality measurement as a basis for resource allocation: research assessment exercises in United Kingdom universities

The research assessment exercises covering universities in the United Kingdom aim to produce quality ratings as a basis for the allocation of much of the research funding from central government. For each subject area a panel drawn from higher education and research users awards a grade to each university department. Each subject is allocated a predetermined share of the total research fund. The sum each university then receives is determined by the number of active research workers and the grades awarded.
The first research assessment exercises were carried out in 1986 and 1989. By the time of the 1992 exercise the number of universities in the United Kingdom had increased dramatically with the conferment of university status on all the former polytechnics and a small number of other institutions. This paper describes the way in which quality was assessed and the results of the 1992 exercise together with the changes made for the next exercise taking place in March 1996.
The research assessment exercises have required the new universities (principally the former polytechnics) to compete on an equal footing with the established universities for research funding and thus for their staff to engage more fully in research. The result is a major change in the environment, particularly in the new universities. This paper offers a preliminary examination of the attempts by universities to this change with the consequential effect upon the labour market.     

Differential rent and the role of landed property

La rente différentielle, dans la théorie marxiste de la rente fonciére capitaliste, est souvent considérée comme l'appropriation, par les propriétaires, des surprofits résultant de la production sur les terres les plus fertiles, surprofits différentiels dont l'existence serait indépendante de la nécessité du paiement de rente. Dans cette perspective, la rente différentielle n'influe pas sur le procès d'accumulation du capital, ni sur la valeur d'échange des marchandises. La thèse développée ici est que l'analyse de la rente différentielle (type II) dans Le Capital montre que l'existence de cette rente conduit à des effets opposés, et que la conclusion selon laquelle la rente différentielle n'est qu'une redistribution de surprofit préexistant ne peut découler que d'une problématique ricardienne ou marginaliste. Après avoir explicité les différences entre les théories de la rente différentielle de Marx et de Ricardo, il est montré que la théorie marxiste de la valeur constitue un élément décisif de la constitution de ces différences. De plus, il résulte du rapport entre la théorie marxiste de la valeur et celle de la rente différentielle que les effets de cette catégorie de rente sont distincts selon qu'il s'agit de l'agriculture ou de l'industrie. Et ceci permet, entre autre, de théoriser l'impact des localisations sur le procès de production et sur la valeur des marchandises. Ce qui mène, au bout du compte, à s'interroger sur la pertinence des catégories marxistes de rente, rente différentielle comprise, pour l'analyse des mécanismes créateurs de rente dans les zones urbaines.     

Reviews

GRAND STRATEGY OR DRAINING LAKE WINDERMERE WITH A TEASPOON?

Chandler, J.A. and Lawless, P. 1985: Local Authorities and the Creation of Employment. Aldershot: Gower, £14.50 hardback only.

HOW IT'S DONE IN HAMMERSMITH.

Allan, M., Fenton, M. and Flockhart, A. 1985: Creating a local economic development network. A case study of Hammersmith and Fulham. Dundee Park Place Publishing/The Planning Exchange, £7.50 paperback.

ENTREPRENEURSHIP FOR THE UNEMPLOYED?

Nabarro, R., Davies, R., Cobbold, C. and Galley, N., 1986: Local enterprise and the unemployed. London: Calouste Gulbenkian Foundation. £4.00 plus 60p postage.

THE CO-OP BANK LOOKS AT CO-OPS.

P. A. Management Consultants Ltd. and Co-operative Bank plc, 1985: Workers Co-operatives Past, Present and Future. Manchester: P. A. Management Consultants (Manchester), £20.00.

HOUSING LAND: ARE PLANNERS LOSING THEIR GRIP?

Rydin, Yvonne, 1986: Housing Land Policy. Aldershot: Gower, £15.00 cloth.

MONETARISTS LOOK AT LIVERPOOL.

Liverpool Research Group in Macroeconomics, 1986: Merseyside Economic Prospect Vol. 1, No. 1 February 1986. Liverpool: University of Liverpool, £6.00.

THE FORGOTTEN DEPRIVATION OF RURAL AREAS.

Association of District Councils, 1986: The Rural Economy At The Crossroads—A Review of Rural Needs and Problems in the '80s. ADC,

9 Buckingham Gate, London SW1E 6LE. £5.00.

THE LONDON FINANCIAL STRATEGY.

Greater London Council, 1986: London Financial Strategy London: Greater London Council, £3.50 (now available from London Strategic Policy Unit, 20 Vauxhall Bridge Road, London SW1).     

The assessment of the impact of oil palm and rubber plantations on the biotic and abiotic properties of tropical peat swamp soil in Indonesia

Current intensification of agricultural activities in Indonesia has led to increased use of tropical peat swamp forests for agriculture. Ideally, peat swamp ecosystems should not be disturbed as they provide essential services such as soil erosion control, ecosystem stabilization and moderation of climate and energy fluxes as well as reducing carbon emission and conserving biodiversity. In this study, agricultural land from Giam Siak Kecil–Bukit Batu Biosphere Reserve in Indonesia was evaluated to assess the impact of oil palm (burning and without burning) and rubber (5–10 and >40 years old) plantations on soil properties through comparisons with soils from a natural forest (NF). Substantial changes in the physico-chemical properties of soils from both plantations were observed including significant reductions in soil organic matter (4–18%) and water holding capacity (22–53%), but an increase in bulk density (ρb) (0.08–0.17?g?cm^?3). A significant increase in bacterial biomass was also observed following conversion of the NF to plantation (p<0.05). However, the oil palm plantation (OPP) (without burning) showed reduced microbial activities and the lowest Shannon diversity values (2.90) compared to other samples. Community-level physiological profiling showed impaired community function only in soils from the OPP but higher CO₂ exchange rates in most plantation soils. Soils from the rubber plantation (RP) were less impaired in terms of their natural function and therefore RPs appeared to be more suitable for sustainable agricultural use than OPP.     

Within trial cost-utility analysis of disease management program for patients hospitalized with atrial fibrillation: results from the SAFETY trial

Abstract

Background: The potential impact of disease management to optimize quality of care, health outcomes, and total healthcare costs across a range of cardiac disease states is unknown.

Methods: A trial-based cost-utility analysis was conducted alongside a randomized controlled trial of 335 patients with chronic, non-valvular AF (without heart failure; the SAFETY Trial) discharged to home from three tertiary referral hospitals in Australia. A home-based disease management intervention (the SAFETY intervention) that involved community-based AF care including home visits was compared to routine primary healthcare and hospital outpatient follow-up (standard management). Bootstrapped incremental cost-utility ratios were computed based on quality-adjusted life-years (QALYs) and total healthcare costs. Cost-effectiveness acceptability curves were constructed to explore the probability of the SAFETY intervention being cost-effective. Sub-group analyses were performed based on age and sex to determine differential cost-effectiveness.

Results: During median follow-up of 1.75?years, the SAFETY intervention was associated with a non-statistically significant increase in QALYs (0.02 per person) and lower total healthcare costs (–$4,375 per person). Although each of these findings were not statistically significant, the SAFETY intervention was found to be dominant (more effective and cost saving) in 58.8% of the bootstrapped iterations and cost-effective (more effective and gains in QALYs achieved at or below $50,000 per QALY gained) in 61.5% of the iterations. Males and those aged less than 78?years achieved greater gains in QALYs and savings in healthcare costs. The estimated value of perfect information in Australia (the monetized value of removing uncertainty in the cost-effectiveness results) was A$51 million, thus demonstrating the high potential gain from further research.

Conclusions: Compared with standard management, the SAFETY intervention is potentially a dominant strategy for those with chronic, non-valvular AF. However, there would be substantial value in reducing the uncertainty in these estimates from further research.

Trial registration: Australian New Zealand Clinical Trials Registry identifier: ACTRN12610000221055.