生物电子等排原理在新药设计中的应用

探索生物电子等排原理在新药研究中应用的规律,推动新药研究的进展;通过查阅文献资料,阐述生物电子等排的定义及各类生物电子等排的特点、使用范围、典型事例;表明生物电子等排既有外层电子总数相等的原子或基因的替换,也有在体积、形状、构象、电子分布、脂水分配系数、pKa、化学反应性(包括代谢相似性)和氢键成键能力等重要参数上存在相似性的原子或基团的替换,是对已知药物的结构改造或结构修饰;所产生新化合物优于、近于或拮抗原来药物的作用,具有成功率高、风险小、投资少的特点,在新药研究中占有重要的地位。应用生物电子等排体进行新药设计,尤其适合我国制药工业现有的实际情况。     

Unit initial public offerings: Staged equity or signaling mechanism?

We investigate the use of unit (i.e., package) initial public offerings by Australian industrial firms and conclude that their use reflects their role as a signaling mechanism (Chemmanur and Fulghieri, 1997), as distinct from the agency–cost explanation offered by Schultz (1993). From a sample of 394 IPOs between 1976 and 1994, the 66 firms making unit offerings are typically riskier, use less prestigious underwriters and have a lower level of retained ownership than other IPO firms. While these results are also consistent with Schultz's agency cost explanation, other results we report are not. We find no difference in underpricing etween unit IPOs and other IPO firms, nor are there any significant differences in the planned uses of proceeds reported in the prospectus, post–listing failure rates or secondary equity offerings of the type predicted by Schultz. We do however, report evidence consistent with a prediction unique to the signaling explanation. After controlling for the level of ownership retained by insiders, the proportion of firm value sold as warrants is increasing in IPO firms' riskiness.     

Characteristics of Earnings-Leading Versus Price-Leading Firms

This study attempts to identify firm characteristics that explain the disparity between the information content of accounting earnings and stock prices. Granger's causality concept was employed to classify sample firms into four groups: price-leading firms, feedback-system firms, earnings-leading firms, and no-causation firms. The feedback-system firms were either combined with the no-causation firms or eliminated entirely to form three sample groups. The entire sample firms then were divided into two classes. The first is for estimation, and the second is for prediction. Results indicate that firm size, capital structure, R-square of regressing prices at time t against earnings at time t – 1, R-square of regressing earnings at time t against prices at time t – 1, and percentage of shares held by institutions are the significant explaining variables. The application of the coefficient estimates to the hold-out sample indicates that 76.2% of the firms can be correctly classified into the corresponding groups. These results were consistent with those from canonical discrimination and other multivariate statistical methods.     

个人理财市场细分及客户群差异性分析

目前我国商业银行个人理财业务尚处于初级阶段,个人理财市场的细分还很简单,尚没有进行更深入的、多层次的分析。针对这一情况,本文借鉴“家庭生命周期”的分析思路,选取人口统计变量和家庭生命周期变量等综合指标作为客户细分变量,对给定的调查样本实施市场细分。为此,本文利用方差分析探讨了一般客户、重要客户、未来潜力客户和战略客户4组客户理财个性的差异性以及对银行理财服务质量期望的差异性。同时,还分析这组客户对主要理财工具、理财产品的需求特点,并在市场细分的基础上制定出4差异化的、有针对性的营销策略。     

我国国家助学制度的问题分析与财政对策选择

国家助学制度是解决大学生入学机会公平的一种有效的手段,在我国已有50多年的历史,目前已形成了多元混合的制度体系,为我国教育改革和发展提供了前提条件,但也存在不足和缺陷。本文从我国国家助学制度现行状况入手,对存在的问题进行了剖析,提出了若干可行的解决建议。     

IPO anomalies and innovation capital

Innovation capital are typically expensed and/or unrecognized as assets under current generally accepted accounting principles. This results in accounting-related information asymmetry. This paper examines the association of innovation capital (as measured here by the proxies of R&D expenditures and granted patents) and initial public offerings (IPO) anomalies. These anomalies include initial IPO underpricing, duration of honeymoon (a distinct feature of the Taiwanese IPO environment), and long-term performance. The theoretical model underlying this research is a signaling model. The results indicate that more innovative firms are more likely to be underpriced, and have longer honeymoon periods than less innovative firms. Further, the more innovative firms have positive and growing long-term market-adjusted returns. This stands in contrast to the declining long-term stock performance of initial public offering firms that is evidenced in the literature. We conclude that pre-IPO research and development expenditures disclosed in the IPO prospectus, official monthly reports of newly developed patents released to the public, and the frequency of patent citations significantly signal both underpricing and future market performance of IPO firms in Taiwan.     

论小型冷热电联产

介绍了小型冷热电联产系统的特点和主要设备的现状.阐述了如何在西气东输的前提下,大力发展以小型、清洁冷热电联产为代表的第二代能源系统,促进国民经济的发展.     

面向项目和岗位建立与优化建设项目知识库

文章充分利用项目和岗位在实践中承载知识的有利条件，面向项目和岗位，提出了在建设项目管理中建立与优化知识库的新思路，即应该从知识的来源分类存贮知识，并根据知识的应用范围和应用条件建立分级分类的知识库体系；通过串行和并行智能体Agent辅助岗位完成知识的采集与挖掘，使整个知识库体系在应用中具备自我学习和发展的能力。     

New MII Circular on Telecom and Internet Firms

On July 13, 2006, the Min istry of Information Indus try of the People＇s Repub lic of China （＂MII＂） issued a new notice concerning foreign-invested telecom and internet companies in China. MII＇s ＂Notice on Strengthening Regulation of Foreign Investment in and Operations of Value-Added Telecom Services＂ （the ＂MII Circular＂）, further clarifies the existing regulatory framework governing foreign investment in internet and other value-added telecommunications （＂ VATS ＂） businesses in China.     

2006年石油价格展望

本文对影响2006年石油价格的因素做了系统分析。认为2006年形成油价风险的主要动因已从需求的波动转向供给的波动;2006年油价将由于供求的脆弱平衡维持高位运行的格局,并且,由于供给链中潜在的危机,油价波动性将会非常大;但在全球经济增速下降、石油需求增长放缓、石油生产国家和公司仍然在努力满足市场需求、炼油瓶颈有望缓和的大背景下,油价在2006年按2005年可比价格计不会大幅上升,不会对全球经济产生重大负面影响。