Healthcare resource utilization by patients with treatment-refractory myasthenia gravis in England

Aims: To examine healthcare resource utilization associated with refractory myasthenia gravis (MG) in England.

Materials and methods: This was a retrospective cohort study of linked data from the Clinical Practice Research Datalink and the Hospital Episode Statistics database collected between 1997 and 2016. Included patients were ≥18?years of age at the index MG diagnosis. Patients with refractory MG were identified using an algorithm based on treatments received. Healthcare resource utilization since the index date was compared between refractory and non-refractory cohorts.

Results: The study included 1149 patients with MG, of whom 66 (5.7%) were refractory. Sex and age at diagnosis did not significantly differ between the refractory and non-refractory cohorts. Rates of healthcare resource utilization per person-year were significantly higher (p?p?Limitations: The algorithm for identifying refractory patients did not include clinical criteria. Also, treatments administered in hospitals or by specialists were not available in the databases.

Conclusions: Patients in England with refractory MG more often visit healthcare providers, are hospitalized and visit an emergency room than patients with non-refractory MG.     

Health state utilities associated with caring for an individual with cutaneous T-cell lymphoma (CTCL)

Abstract

Aim

Cutaneous T-cell Lymphoma (CTCL) is a rare form of non-Hodgkin lymphoma characterized by skin lesions, which can negatively impact the quality of life of both patients and their caregivers. The Decision Support Unit (DSU) at the National Institute for Health and Care Excellence (NICE) in the UK recently outlined a rationale for the inclusion of caregiver burden in economic evaluations. This study aimed to estimate utilities for health states associated with being a caregiver for an individual with CTCL at different stages of treatment.     

Market reactions to the disclosure of internal control weaknesses and to the characteristics of those weaknesses under section 302 of the Sarbanes Oxley Act of 2002

We examine the stock price reaction to management’s disclosure of internal control weaknesses under §302 of the Sarbanes Oxley Act and to the characteristics of these weaknesses, controlling for other material announcements in the event window. We find that some characteristics of the weaknesses—their severity, management’s conclusion regarding the effectiveness of the controls, their auditability, and the vagueness of the disclosures—are informative. We also find that the information content of internal control weakness disclosures depends on the severity of the internal control weakness. Moreover, in a sub-sample uncontaminated by other announcements in the event window, we find negative price reactions to the disclosure of internal control weaknesses and material weaknesses.

Foreign Aid, the Real Exchange Rate, and Economic Growth in the Aftermath of Civil Wars

Foreign aid, the real exchange rate (RER), and economic growthare three key variables that shape the aftermath of civil warsin many developing countries. Panel estimations drawn from asample of 39 conflict and 44 nonconflict countries between 1970and 2004 indicate that although postconflict countries receivelarger aid flows and exhibit moderate RER overvaluation afterpeace is attained, overvaluation cannot be traced to aid. Yetforeign aid is among the significant determinants of the equilibriumRER. Aid is also an important determinant of economic growth,particularly after peace is reached. Aid exhibits decreasingreturns, however, and interacts negatively with RER overvaluation.RER overvaluation reduces growth, but this effect is amelioratedby financial development. Postconflict policies should thereforeaim to use aid prudently, avoid RER misalignment, and supportfinancial and capital market development to achieve high andstable growth in the aftermath of war and beyond.     

Tunneling and propping: A justification for pyramidal ownership

This paper links existence of the pyramidal ownership structure to tunneling and propping. Tunneling refers to a transfer of resources from a lower-level firm to a higher-level firm in the pyramidal chain, whereas propping concerns a transfer in the opposite direction intended to bail out the receiving firm from bankruptcy. We show that tunneling alone cannot justify the pyramidal structure unless outside investors are myopic, since rational outside investors anticipate tunneling and adjust their willingness-to-pay for the firm’s shares accordingly. With propping, however, they may be willing to be expropriated in exchange for implicit insurance against bankruptcy.     

Non‐profit vulnerability: An exploratory study

This mixed‐method study explores the symptoms and potential causes of non‐profit vulnerability within the Australian context. Following two focus groups with CEOs and Chairs of non‐profit organizations, an online survey was developed, pilot tested and distributed to non‐profit CEOs. Our findings suggest three symptoms that might be particularly useful in identifying non‐profit vulnerability: a substantial increase in unit costs/delivery hours; a substantial increase in the proportion of administration to program expenses; and a reduced ability to pursue the organization's mission. The results also suggest various potential causes of non‐profit vulnerability; in particular, Board inadequacies; External environmental threats; Project management issues; and Funding constraints.     

Kenya's focus on urban vulnerability and resilience in the midst of urban transitions in Nairobi

ABSTRACT

Addressing urban vulnerability requires an understanding of the underlying determinants of resilience for individuals, households, communities and institutions – to withstand shocks, to adapt and to change. Analysing urban resilience utilises the results of five rounds of the Indicator Development for Surveillance of Urban Emergencies surveys conducted in three informal settlements of Nairobi. Results show a significant deterioration in food security and household hunger in marginalised urban populations, with other deprivations including insecurity, negative coping behaviour and inadequate access to water and sanitation. Within slum populations, there was a significant variation in income and expenditure (p?<?0.05) with lowest income quintiles spending over 100% of their income on food. Significant gender disparities have been shown in lowest income quintiles, with female breadwinners earning 62% compared with male breadwinners (p?<?0.05). Recommendations from this analysis include establishing thresholds for vulnerability and concrete dimensions for measuring resilience that can initiate and guide related interventions.     

Relating to marketing? Why relationship marketing works for not-for-profit organisations

Not-for-profit organisations often consider marketing to be inappropriate to their needs. This may well be true if marketing is thought of in its traditional and outdated ‘transactionally’ focused mode. Relationship marketing, with a focus on relationships rather than transactions, and multiple markets, has the ability to meet the unique needs of not-for-profit organisations. Copyright © 1999 Henry Stewart Publications     

Exploitation or Choice? Exploring the Relative Attractiveness of Employment in the Maquiladoras

This study investigates the relative attractiveness of production level jobs provided by multinational firms in Mexico's maquiladora industry. We take the position that workers themselves are an important and often overlooked source of information relevant to the controversy focusing on the responsibilities of multinational companies to their employees in the developing world. We conducted interviews with 59 maquila production level workers in the Mexican cities of Cd. Juárez and Chihuahua. Using a relative attractiveness framework that compared maquila jobs to other employment available in the local economy, maquila line and technical workers responded to questions addressing why they were working at a maquila, their work history, the attractiveness of maquila jobs compared to both their prior jobs and the jobs held by friends and family, and whether they planned to continue working in the maquilas. While the responses from maquila workers are diverse, they suggest that maquila jobs provide attractive employment for the economically disadvantaged in Northern Mexico.