非酒精性脂肪性肝炎治疗靶点和靶向药物研发进展

介绍了治疗非酒精性脂肪性肝炎的相关靶点和靶向药物研发方面的进展,分别简述了过氧化物酶体增殖物激活受体、乙酰辅酶A羧化酶、胰高血糖素样肽-1、甲状腺激素受体β、法尼醇X受体、成纤维细胞生长因子19/21、凋亡信号调节激酶1和C-C趋化因子受体2/5等多种非酒精性脂肪性肝炎治疗新靶点,分析了靶点相关药物及其在治疗非酒精性脂肪性肝炎的研发进展及其优缺点。分析表明,通过探索非酒精性脂肪性肝炎的相关靶点及研发的靶向药物,有助于解除非酒精性脂肪性肝炎给人类健康带来的巨大威胁。基于此,对其发展前景进行展望,指出今后可以在以下方面对治疗非酒精性脂肪性肝炎进行深入研究：1)找到非酒精性脂肪性肝炎主要致病机理,从源头治疗非酒精性脂肪性肝炎;2)针对非酒精性脂肪性肝炎的不同靶点进行药物联合治疗;3)研发新的治疗技术(基因疗法、核酸药物以及抗体偶联药物等),将其应用到非酒精性脂肪性肝炎治疗领域。     

The effects of multilateral trading systems on risk and return in equity markets

The event study methodology of Brown and Warner (1985) is adopted and augmented to evaluate the effect of the launch of multilateral trading systems on risk and return in equity markets. The methodology is supplemented with various techniques, such as the nonparametric ranking test and kernel regression, to find out if announcements about the introduction of Chi-X Australia generated abnormal returns (ARs). Asset pricing models are fitted with interaction variables, while GARCH, threshold ARCH (TARCH), exponential GARCH (EGARCH) and power-ARCH (PARCH) are used to determine changes in systematic risk. We find evidence in favour of Fisher’s separation theorem and detect a new market anomaly, which we call the ‘Fisher market anomaly’. Our results show that Chi-X system testings affect ARs. Consistent with the adaptive expectations theory, we confirm that the first announcement about the launch of Chi-X affected systematic risk the most. In addition, we identify industry and firm effects in risk analysis.     

多市场接触对新市场进入及绩效的影响 ——基于10家股份制商业银行的研究

企业在多个市场的竞争互动构成了多市场接触,相较传统的竞争研究,多市场接触更为真实、动态地反映了企业竞争的实际局面。本文以中国10家股份制商业银行为研究对象,研究了多市场接触对银行进入竞争对手所在市场可能性的影响,资源相似性和影响范围在其中发挥的调节作用以及多市场接触对银行绩效的影响。实证结果表明：公司进入竞争对手所在市场的可能性随着多市场接触水平的提升而增大,但偶然形成的多市场接触则与其不相关;相较低资源相似性的公司而言,高资源相似性的公司多市场接触水平对新市场进入的作用将更强;当公司之间是互换性的多市场接触时,多市场接触对新市场进入的作用将减弱;当其他要素保持不变时,公司的绩效随着多市场接触水平的提升而提升。     

现代健康观对我国医改的启示

现代人的健康观是整体健康,医学重点已从诊断治疗转变为预防保健;健康是一种人力资本,用于医疗方面的开支属于＂劳动能力的修理费用＂;＂健康＂已被提到公民福利和国家义务的层面,对国民健康的保障能力要用＂可及性＂和＂可得性＂这两个指标作为标准。现代健康观启示我们：对医改应预防与治疗相结合、遏制医疗费用＂黑洞＂、统筹城乡医疗资源的均衡配置等。     

服务场景中象征要素对顾客行为意愿的影响

从场景印象和顾客自我一致性的角度,深入探讨服务场景中的象征因素对顾客行为意向的作用机理。实证研究结果表明:服务场景中的象征因素有助于顾客形成良好的场景印象,而场景印象显著积极影响顾客的情绪、感知服务质量和自我一致性判断;上述变量进一步促进顾客的行为意向;消费类型对象征因素和场景印象间的关系发挥显著的调节效应。     

广东省服务业产业关联效应研究——基于投入-产出法

在21世纪在全球经济发展转型与经济服务化背景下,广东省步入经济发展方式转变和结构调整的工业化中后期阶段,服务业对GDP、就业及经济增长的贡献越来越大,服务业内部各行业之间的关联互动效应对于理解服务业各行业之间的经济关联及其政策涵义有重要意义.基于服务业的四分类法,在2002和2007年广东和中国的投入产出表数据基础上,利用投入产出模型对广东服务业各行业间的产业关联进行分析.通过对广东服务业部门间产业关联指标分析,得出三点结论:第一,广东服务业的内部产业结构层次不尽合理,生产性服务业比重偏低,而房地产业比重偏高,尤其是新兴服务业的关联带动作用不够强.第二,广东服务业中的中间产品型产业部门比重不高,对服务业增长乃至整体经济增长的带动作用有待加强.第三,广东服务业部门间的产业关联程度略低于全国平均水平,服务业内部结构有待进一步优化.     

Performance effects of category assortment and stock allocation decisions for a cash-and-carry wholesaler

This study develops and tests a model of how category assortment, category stock level and within-category stock allocation decisions might affect category sales and stock turnover and reflect category-varying levels of sales heterogeneity and sales volatility. In doing so, it addresses recent calls to consider multiple dimensions of assortment planning. It uses the cash-and-carry wholesaling setting to isolate non-space-related assortment planning and performance variables otherwise difficult to treat in a conventional retailing (e.g. supermarket) context. It develops a structural equation model of how category sales volatility and heterogeneity, as antecedents, might influence both category assortments and stock allocations and thus, in turn, influence category performance.     

Learning Approaches and Outcome‐Based Teaching and Learning: A Case Study in Hong Kong,China

Outcome‐based education is a pedagogical process which focuses on the achievement of certain specified results. Outcome‐based teaching and learning (OBTL), therefore, is concerned with curriculum design and ensuring that the contents, delivery, activities, and assessments are all aligned to help facilitate students to attain specific intended learning outcomes. This study explores whether and how outcome‐based teaching impacts on the learning approaches of one cohort of undergraduate business students at a university in Hong Kong, China to undergo outcome‐based teaching, newly introduced as part of a university‐wide policy to adopt OBTL. The learning approaches of these business students were measured using John Biggs's (1987 Biggs, J. 1987. Student approaches to learning and studying, Melbourne: Australian Council for Educational Research.  [Google Scholar]) Study Process Questionnaire (SPQ) to determine whether these students tended to favor surface learning approaches, deep learning approaches, or achieving learning approaches upon initial entry into the university. Changes in learning approaches were tracked, after a semester's exposure to OBTL, through survey and focus group interview methods. Findings indicated a significant amount of transference between learning approaches deployed by these students, demonstrating a high level of adaptability.     

我国商业房地产开发项目风险评价分析

商业地产开发项目风险管理中,风险评价是对项目开发风险进行综合评价,并且依据风险程度对项目进行开发风险定级。文章利用模糊数学综合评价法,结合实例,建立了商业地产开发项目风险评价指标体系,给出了商业地产开发项目风险评价模型。从而为决策者进行风险管理提供了定量分析依据,为类似商业地产开发项目风险管理提供了参考。     

城市公共物流信息平台功能与结构设计

城市公共物流信息平台的建设是发展现代物流的核心和关键,通过建设物流信息平台可以极大地推动现代物流向信息化方向发展。通过对城市公共物流信息平台的概念、特征、作用和意义等分析,探讨了城市公共物流信息平台的系统功能与结构,在此基础上设计了信息平台的总体框架、层次结构及软硬件。