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21.
In 2003 Japan proposed a Climate Change Tax to reduce its CO2 emissions to the level required by the Kyoto Protocol. If implemented, the tax would be levied on fossil fuel use and the revenue distributed to encourage the purchase of energy efficient equipment. Analysis using the MIT Emissions Prediction and Policy Analysis (EPPA) model shows that this policy is unlikely to bring Japan into compliance with its Kyoto target unless the subsidy encourages improvement in energy intensity well beyond Japan’s recent historical experience. Similar demand-management programs in the US, where there has been extensive experience, have not been nearly as effective as they would need to be to achieve energy efficiency goals of the proposal. The Tax proposal also calls for limits on international emission trading. We find that this limit substantially affects costs of compliance. The welfare loss with full emissions trading is 1/6 that when Japan meets its target though domestic actions only, the carbon price is lower, and there is a smaller loss of energy-intensive exports. Japan can achieve substantial savings from emissions trading even under cases where, for example, the full amount of the Russian allowance is not available in international markets.  相似文献   
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We examine the connection between Walrasian equilibria of a limit economy (with infinitesimal firms) and the noncooperative (Cournot) equilibria of approximating finite economies (with significant firms). Following earlier work of Novshek and Sonnenschein we allow for set-up cost and permit a minimal form of mixed strategies. We depart from them by requiring that the aggregate production set exhibits some degree (however small) of decreasing returns. Contrasting with their results, it is shown that a (regular) Walrasian equilibrium of a limit economy can always be approximated by a sequence of noncooperative equilibria for the tail of the approximating (finite) economies. Thus, there is a surprising qualitative discontinuity when one passes from the Novshek-Sonnenschein case of aggregate constant returns to scale of the decreasing returns case of this paper.  相似文献   
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Background: Inhibitor development to factor VIII (FVIII) hemophilia therapy results in increased complications and substantial economic costs. The SIPPET study, the first randomized controlled trial to compare the immunogenicity of plasma-derived FVIII (pdFVIII)/von Willebrand factor (VWF) and recombinant-DNA-derived FVIII (rFVIII), demonstrated higher inhibitor rates in previously untreated patients (PUPs) treated with rFVIII than in PUPs treated with pdFVIII/VWF.

Objective: To quantify the economic impact of treating PUPs with pdFVIII/VWF vs rFVIII.

Methods: An Excel-based clinical and economic model was developed from a US healthcare payer perspective and run over a 5-year period. The analysis utilized a cohort approach to model patient treatment and outcomes over a monthly cycle to quantify differences in costs of FVIII, bypassing agents, and hospitalizations for serious bleeds. Rates of high-titer inhibitor development were obtained from the SIPPET study. Patients developing high-titer inhibitors were treated with immune tolerance induction (ITI). Patients who developed low-titer inhibitors and those who did not develop inhibitors continued their usual FVIII treatment. Patients who were successfully treated with ITI returned to FVIII treatment, while unsuccessfully treated patients received bypassing agents. Total costs per treated patient were estimated and a one-way sensitivity analysis was conducted to quantify the impact of parameter uncertainty on the model outcomes.

Results: Total cumulative costs per patient over 5 years were $834,621 for pdFVIII/VWF patients and $1,237,163 for rFVIII patients, representing a total saving of $402,542 per patient over the 5-year period, for an average annual saving of $80,508 per patient.

Conclusions: Based on data from the SIPPET study, this analysis found that initiating FVIII treatment in severe hemophilia A PUPs with pdFVIII/VWF has the potential to offer substantial cost savings to healthcare payers, amounting to a one-third reduction in costs.  相似文献   
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Zimbabwe has recently gone through a widely criticised land reform process that is argued to be the cause of subdued agricultural production. This paper attempts to present a counterfactual picture of the maize market in Zimbabwe had land reform been managed appropriately. The counterfactual is developed through a partial equilibrium framework in order to quantify the impact of the land reform programme. This, to our knowledge, is the first attempt at applying a partial equilibrium framework to an analysis of the impact of land reform. The results of the post-2000 land reform policy simulation showed that actual total maize output was lower than what could have been produced if it was under a pre-2000 land reform system. The study validates the assertion that land reforms contributed to the contraction of output. These results suggest the need for a well planned and executed land reform process, which can still play an important role in output growth and food security.  相似文献   
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More organizations are finding secular counseling provided by employee assistance programs (EAPs) is inadequate for many employees. As a result, increasing numbers of employers are providing services of workplace chaplains. Chaplain services are not necessarily part of the recent fad toward "spirituality" in organizations, but rather address the needs of an increasingly non-churchgoing culture living in a more stressful world.  相似文献   
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Abstract The research question in the present article can be phrased in the following way: what are the elements which influence the perception of the utility of information received from another function? A field study research has been conducted in 40 Belgian companies. In each company, we have studied two on-going innovation projects (one planning project, one development project). Crossfunctional communication behaviours at the R&D/marketing interface have been measured by means of mailed structured questionnaires. Three-hundred and eighty-six questionnaires have been returned. The data analyses show that there are four underlying information dimensions, i.e. the perceived relevance, the perceived comprehensibility, the perceived novelty and the perceived credibility of information. We also discuss some contingency variables (function of the message receiver, stage in the innovation process) that might moderate the impact of these dimensions. It will be shown that the interaction between source and receiver has a significant impact on the perceived credibility, the perceived comprehensibility and the perceived novelty of the received information.  相似文献   
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