Assessing the burden of illness from cervical dystonia using the Toronto Western Spasmodic Torticollis Rating Scale scores and health utility: a meta-analysis of baseline patient-level clinical trial data

Purpose:

This study aimed to explore the burden of illness associated with cervical dystonia (CD), including possible demographic and humanistic correlates of baseline disease severity.

Methods:

The analysis involved the five multinational randomized, placebo-controlled clinical trials that had evaluated the efficacy and safety of Dysport® in patients with CD, including assessment using the Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS). Patient-level TWSTRS scores from the individual studies were meta-analysed to estimate disease severity at baseline. One of the studies had reported Short Form-36 (SF-36) Health Survey quality-of-life measures, and these data were used to investigate whether the severity of CD was associated with humanistic outcomes, as measured by health utility. A generalized regression model was then applied to explore potential correlation between TWSTRS scores and utilities.

Results:

The estimated pooled mean baseline severity of CD in clinical trial entrants, as measured by TWSTRS score, was 43.23 (95% CI?=?39.31–47.15). In general, disease severity was significantly greater in patients aged over 40 years (compared to the reference group aged 18–30 years). However, there was no correlation between disease severity and other demographic characteristics (e.g., weight, height, gender). Higher TWSTRS scores correlated with worse health-related quality of life as perceived by patients and was reflected in health utility (R^2?=?0.133).

Conclusions:

This study was able to define TWSTRS scores in patients with CD in terms of associated utility. This approach could help in capturing the disease’s burden through measures that are more tangible than TWSTRS scores to patients, carers, clinicians, and healthcare payers.     

The Institution,the Economy and the Market: Karl Polanyi's Institutional Thought for Economists

This paper aims to clarify the logical structure of Karl Polanyi's concept of institution, especially with regard to his most important contribution to political economy—the conception of self-regulating markets as institutions. Although Polanyi did not provide a well-developed concept of institution, this article argues that such a concept exists in his work. Moreover, there is in Polanyi's work a sophisticated institutionalist account of the self-regulating market that has been largely overlooked as Polanyi does not present it explicitly. Analyzing the economy as an institutionalized process, as Polanyi does, reveals that the market is neither a natural nor a spontaneous phenomenon—a conclusion that runs counter to conventional economic thinking. Polanyi's approach enables us to view capitalism (the ‘market society’ in Polanyi's language) through a highly specific cultural fact: the fiction of the self-regulating market. This institutional perspective needs to be reassessed beyond new-institutionalist theoretical constructions.     

The Effects of Korean Pop Culture on Hong Kong Residents' Perceptions of Korea as a Potential Tourist Destination

The goal of this study is to assess the influences that Korean pop culture has on Hong Kong residents' perceptions of Korea as a potential tourist destination. Among the 500 distributed questionnaires, 456 were collected. Finally, 440 usable surveys were used for data analysis after eliminating 16 questionnaires with multiple missing answers that were deemed unusable. Data analyses produced many meaningful results. For example, respondents who were less educated and tended to spend more on Korean cultural products had a higher intention to visit Korea after they tasted Korean food. Expenditures on Korean cultural products were a significant contributor to Hong Kong residents' intention to visit Korea after experiencing the three types of Korean pop culture used in this study. Results of this study confirm those of previous studies, which found that the media had a significant influence on a person's choice of tourist destination.     

The Influence of a TV Drama on Visitors’ Perception: A Cross-Cultural Study

The goal of this study is to assess the effects the Korean food featured on the Korean TV drama series Daeganggeum has on the perceptions of national image and intention to visit Korea by residents of Hong Kong, Taiwan, and Thailand. Estimates of structural equation models are used for samples from the three countries to produce information for comparing relationships between variables: on preferring Korean food, the national image of Korea, and the intention to visit Korea for food tourism. The results show similarities and differences between the three national groups. Virtually identical models are found for Hong Kong and Taiwan groups. However, the comparison of Hong Kong and Taiwan groups to the Thailand group demonstrate differences. Specifically, in the Thai sample, distinctiveness of Korean food culture significantly increases the intention to visit Korea for food tourism. All three national groups demonstrate that a strong relationship exists between the national image of Korea and the intention to visit Korea for food tourism.     

Middle-class black consumers and intensity of ethnic identification

This article reports on an empirical study analyzing the differences between black (buppies) and Anglo (yuppies) middle-class consumers responding to advertising featuring celebrity endorsers. Particular attention is given to variability within the black consumer segment by examining intensity of identification and socioeconomic status. Using a laboratory experiment, 160 subjects were drawn from a large metropolitan area. The implications are that while black consumers who have moved up the socioeconomic ladder have similar responses to their Anglo counterparts, they should not necessarily be viewed as having lost strong ethnic identity.     

Better late than never: a study of late entrants in household electrical equipment

For the most part, studies on timing of entry have attempted to determine the advantages that early entrants may be able to develop and hold over subsequent entrants. Given that a large number of firms attempt to enter at a much later stage in the development of the market, it is particularly surprising that little research has attempted to examine the differences in the ability of late movers to penetrate the market. In this paper, we focus exclusively on late movers and examine the extent to which their early success can be tied to existing market conditions, their resource strengths, and their strategic positioning. Copyright © 2003 John Wiley & Sons, Ltd.