Co-production of social research: strategies for engaged scholarship

There are incentives on both sides of the practitioner–academic divide for co-production of research. This article identifies and evaluates five strategies for achieving more engaged and engaging scholarship. At one end of the spectrum are models involving relatively low levels of involvement by practitioners, for example as the providers of data or passive recipients of research findings. At the other end, practitioners play an active role in commissioning, overseeing and learning from studies. Higher levels of engagement should enhance the prospects of utilization but may risk politicizing the research process. So it is important to be clear about the benefits of and barriers to different forms of co-production and to recognize what works best, in which circumstances and for whom.     

Cost-effectiveness of telaprevir in combination with pegylated interferon alpha and ribavirin in previously untreated chronic hepatitis C genotype 1 patients

Background:

Telaprevir (T, TVR) is a direct-acting antiviral (DAA) used for the treatment of genotype 1 chronic hepatitis C virus (HCV) infection. The sustained virological response (SVR) rates, i.e., undetectable HCV RNA levels 24 weeks after the end of treatment, is what differentiate treatments. This analysis evaluated the cost-effectiveness of TVR combined with pegylated interferon (Peg-IFN) alfa-2a plus ribavirin (RBV), with Peg-IFN and RBV (PR) alone or with boceprevir (B, BOC) plus Peg-IFN alfa-2b and RBV, in naïve patients.

Methods:

A Markov cohort model of chronic HCV disease progression reflected the pathway of naïve patients initiating anti-HCV therapy. SVR rates were derived from a mixed-treatment comparison including results from Phase II and III trials of TVR and BOC, and trials comparing both PR regimens. SVR has significant impact on survival, quality-of-life, and costs. Incremental cost per life year (LY) gained and quality-adjusted-life-year (QALY) gained were computed at lifetime, adopting the (National Health Service) NHS perspective. Cost and health outcomes were discounted at 3.5%. Uncertainty was assessed using deterministic and probabilistic sensitivity analyses. Sub-group analyses were also performed by interleukin (IL)-28B genotype and fibrosis stage.

Results:

Higher costs and improved outcomes were associated with T/PR relative to PR alone, resulting in an ICER of £12,733 per QALY gained. T/PR retained a significant SVR advantage over PR alone and was cost-effective regardless of IL-28B genotype and fibrosis stages. T/PR regimen ‘dominated’ B/PR, generating 0.2 additional QALYs and reducing lifetime cost by £2758. Sensitivity analyses consistently resulted in ICERs less than £30,000/QALY for the T/PR regimen over PR alone.

Limitations:

No head-to-head trial provides direct evidence of better efficacy of T/PR vs B/PR.

Conclusion:

The introduction of TVR-based therapy for genotype 1 HCV patients is cost-effective for naïve patients at the £30,000 willingness-to-pay threshold, regardless of IL-28B genotype or fibrosis stage.     

A Brief Outline of the Israel–Palestinian Conflict

Before we can explore the use of management science, game theory, cognitive science and artificial intelligence to attempt to resolve (or just manage) the Israel–Palestinian dispute, we need some sort of mutual understanding about the conflict. Given such a long and multi-faceted history rife with multiple conflicting claims, interpretations and emphases, all fraught with moral and political implications, it is unlikely that any account will be acceptable to all parties as authoritative. Nevertheless, we must search for some common ground. Our examination of history commences with the life of Abraham, the father of the three great monotheistic religions: Judaism, Christianity, and Islam and continues through to a discussion of Zionism and Arab nationalism. This leads to the creation of the State of Israel on May 14, 1948; celebrated as Yom Ha’atzmaut (Independence Day) and commemorated as ‘al-Nakhba (the catastrophe), according to one’s background. Whilst our discussion concludes with recent events, including the spring 2011 protests and demonstrations spread throughout the Middle East, there is no doubt that during the time between which this article is written and it appears in a journal, momentous events will have occurred.     

Virtual worlds

Games, role‐playing, and simulations as developmental tools have been used in education since the 1800s. An emerging form of collaborative game play is virtual worlds; however, the use of virtual worlds in leadership education has not been fully investigated. The purpose of this article is to (a) demonstrate how virtual worlds are a viable venue for leadership education, and (b) present a hierarchy of skills sets that can be developed in virtual world settings. In doing so, this article provides evidence that virtual worlds can be used as a new instructional delivery environment for leadership education as the appeal and intrinsic nature of virtual environments aligns well with the experiential framework of leadership education.     

Endogenous business cycle propagation and the persistence problem: The role of labor-market frictions

Contrasting sharply with a recent trend in DSGE modeling, we propose a business cycle model where frictions and shocks are chosen with parsimony. The model emphasizes a few labor-market frictions and shocks to monetary policy and technology. The model, estimated from U.S. quarterly postwar data, accounts well for important differences in the serial correlation of the growth rates of aggregate quantities, the size of aggregate fluctuations and key comovements, including the correlation between hours and labor productivity. Despite its simplicity, the model offers an answer to the persistence problem (Chari et al., 2000) that does not rely on multiple frictions and adjustment lags or ad hoc backward-looking components. We conclude modern DSGE models need not embed large batteries of frictions and shocks to account for the salient features of postwar business cycles.     

Biases in option prices : Evidence from the foreign currency option market

This paper examines a European call model of option pricing over a data set which does not suffer from the early exercise problems that have plagued earlier studies of call options on common stocks. We specifically examine a data set of American call prices on spot foreign exchange for which it is plausible to apply an adjusted version of the Garman-Kohlhagen (1983) and Grabbe (1983) European call option model. We make adjustments for interest rate risk and find that the model is nearly unbiased in the valuation of foreign currency options. We conclude that the Geske-Roll (1984) conjecture about dividend uncertainty creating biases in stock option prices holds analogously in the foreign currency option market. Interest rate differential risk (analogous to risky dividends) thus appears to be an important element in the valuation of foreign currency options.     

Individual customers' use and integration of resources: Empirical findings and organizational implications in the context of value co-creation

This article addresses the call for empirical work to contribute to the ongoing critique of service-dominant (S-D) logic, and for an assessment of its potential reach to practitioners. It examines the appropriateness of a model of the resource-based view of consumers in an organizational context — the British Library (BL) — and concludes that the model can be adapted to include individual customers with varying motivations (personal/business) for using the BL's services. A detailed analysis of individual customer's operant resources (enabled through access to 565 messages posted to a BL user support forum) provided a different lens through which the organization could consider strategies to support value co-creation. The outcomes, from a collaborative research process, with executives and senior managers of BL, suggest that a sub-division of customer operant resources into physical, cultural and social has empirical support and managerial relevance, and that a focus on individual customer resources can provide insights into how to manage co-creation of value.     

Can Pre-recorded Evidence Raise Conviction Rates in Cases of Domestic Violence?

This paper explores the association between pre-recorded evidence and court outcomes in cases of domestic violence. Net of controls and time fixed effects, we find that cases with pre-recorded evidence are 3.4 percentage points more likely to result in a conviction. This increase occurs through three channels: a 5.6 percentage point increase in the probability of a conviction among (the one in four) cases that proceed to a defended hearing; a 2.4 percentage point increase in the probability of a guilty plea; and, a 2.4 percentage point decrease in the probability that the prosecution withdraws their case.     

The Destination Marketing Organization as an intelligent agent: Evaluating engagement in knowledge management practices

DMOs have been increasingly called upon to adopt the role of knowledge management, becoming intelligent agents with the capacity to gather, assess, and disseminate information among internal and external stakeholders. While knowledge management has remained a prominent topic in the literature, its application within the field of tourism management has been limited. The purpose of this study, therefore, was to ascertain to what extent DMOs have engaged in knowledge management practices through a nation-wide survey of 30 Canadian DMOs. The results demonstrate that, while DMOs have made progress toward becoming intelligent agents, there remains a long way to go.