Cost and economic burden of adverse events associated with metastatic melanoma treatments in five countries

Objective: To estimate per-event cost and economic burden associated with managing the most common and/or severe metastatic melanoma (MM) treatment-related adverse events (AEs) in Australia, France, Germany, Italy, and the UK.

Methods: AEs associated with chemotherapy (dacarbazine, paclitaxel, fotemustine), immunotherapy (ipilimumab), and targeted therapy (vemurafenib) were identified by literature review. Medical resource use data associated with managing AEs were collected through two blinded Delphi panel cycles in each of the five countries. Published costs were used to estimate per-event costs and combined with AEs incidence, treatment usage, and MM prevalence to estimate the economic burden for each country.

Results: The costliest AEs were grade 3/4 events due to immunotherapy (Australia/France: colitis; UK: diarrhea) and chemotherapy (Germany/Italy: neutropenia/leukopenia). Treatment of AEs specific to chemotherapy (Australia/Germany/Italy/France: neutropenia/leukopenia) and targeted therapy (UK: squamous cell carcinoma) contributed heavily to country-specific economic burden.

Limitations: Economic burden was estimated assuming that each patient experienced an AE only once. In addition, the context of settings was heterogeneous and the number of Delphi panel experts was limited.

Conclusions: Management costs for MM treatment-associated AEs can be substantial. Results could be incorporated in economic models that support reimbursement dossiers. With the availability of newer treatments, establishment of a baseline measure of the economic burden of AEs will be crucial for assessing their impact on patients and regional healthcare systems.     

Human resource management practices and psychological contracts in Swiss firms: an employer perspective

This article investigates the relationship between HRM practices and organisational performance, considering the fulfilment of the psychological contract as an intermediate variable. Apart from testing the influences of a high-investment HRM system index on the psychological contract, the influence of individual HRM practices and their interaction was examined. The sample consisted of HR managers of 92 firms in Switzerland and the data were collected for the Cranfield Network project. The results showed that the high-investment HRM system index predicted the fulfilment of the psychological contract, and some of the individual HRM practices were correlated with the fulfilment of the psychological contract. The interaction effect of performance appraisal and performance-based pay on the fulfilment of the psychological contract showed that performance appraisal is only effective in combination with a tangible consequence in the form of performance-based pay. We neither found a mediation effect for the psychological contract nor an association with organisational performance. This might be due to the fact that the questionnaire was filled in during the financial crisis in 2008 and that the organisational performance was assessed in an economic crisis. Our study sheds light on the relationship between HRM practices and the psychological contract and contributes to the body of research on psychological contracts from a macro level perspective.     

Weighted least squares estimators in possibly misspecified nonlinear regression

The behavior of estimators for misspecified parametric models has been well studied. We consider estimators for misspecified nonlinear regression models, with error and covariates possibly dependent. These models are described by specifying a parametric model for the conditional expectation of the response given the covariates. This is a parametric family of conditional constraints, which makes the model itself close to nonparametric. We study the behavior of weighted least squares estimators both when the regression function is correctly specified, and when it is misspecified and also involves possible additional covariates.     

Looking for people,places and connections: hindrances when working in multiple locations: a review

Mobile multi‐locational workers move a lot spatially, utilise different locations for work and communicate with others via electronic tools. This article presents an analysis of previously published empirical studies focusing on mobile workers' experiences of hindrances in five types of locations. Our review shows that some of the hindrances are unique for certain types of locations, while others recur in all or most of them. The change of physical locations results in continuous searching for a place to work and remaining socially as an outsider in all communities, including the main office. Limited connections and access in used locations seem to be the main challenges of virtual spaces despite of the recent developments in technology. In addition, we discuss the importance to consider hindrances caused by changing contexts as job demands, which can be influenced in work re/designing process.     

Customer co-creation of travel services: The role of company support and customer satisfaction with the co-creation performance

The tourism industry is characterized by high-contact services in which co-creation of customers plays a major role. This paper develops a conceptual model of customer co-creation of tourism services and empirically tests this model in a travel agency context. Applying a SEM-approach, company support for customers is found to significantly affect the degree of customer co-creation. The degree of co-creation further positively affects customer satisfaction with the service company, customer loyalty, and service expenditures. A test of the moderating effect of the customers' satisfaction with their own co-creation performance on satisfaction with the service company and on service expenditures suggests that those customers who are satisfied with their co-creation activities spend more on their travel arrangements, but that they are less satisfied with the company. Important implications for co-creation theory and practice in high-contact service industries can be derived.     

Social partners' levers: job quality and industrial relations in the waste sector in three small European countries

This article examines how social partners in the waste sector in Austria, Bulgaria and Denmark strive to protect job quality from negative impacts of two European trends: privatisation and greening. The article uses qualitative, comparative research to examine social partners' levers for protecting and improving job quality. Three levers are identified: negotiation power, collective agreements and general regulation that facilitate negotiation and social partnership. In general, privatisation has had a negative influence on job quality and the levers of collective actors, whereas the impact of greening is ambiguous, that is, not necessarily positive. The article concludes that stakeholders' ability to improve job quality is contingent upon their activity on both a national and European level.     

When Production and Consumption Meet: Cultural Contradictions and the Enchanting Myth of Customer Sovereignty

ABSTRACT The central cultural contradiction of capitalism, argued Bell some 25 years ago, was the existence of rationalized, disciplined production alongside free and hedonistic consumption. This paper argues that this thesis, although overstated, has resonance within contemporary capitalism. The paper then considers the question of how this contradiction is managed when production and consumption meet directly within the service interaction. On the production-side rationalization is joined by customer-orientation, and on the consumption-side management promotes consumption of the enchanting myth of sovereignty. Here the customer is meant to experience a sense of being sovereign. At the same time the space is created for the customer to be, potentially, substantively directed and influenced to follow the requirements that flow from the rationalized elements of production. Key aspects of the service interaction, including the menu and its presentation, the display of empathy and aesthetic labour, and the use of naming within the service interaction, are analysed in terms of the promotion of the enchanting myth of sovereignty. Consumption, however, is a fragile process, and remains, to an important degree, 'unmanageable'. The analysis, therefore, also examines how the promotion of the enchanting myth of sovereignty systematically creates the conditions for the myth's negation.     

Verbraucherabteilungen in Unternehmen — eine Chance für Unternehmen und/oder Verbraucher? Zu Fornells Beitrag in ZVP, 2, 1978/4

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