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131.
The authors recount their experience of the implementation of lean thinking and Six Sigma in pharmaceutical development research and development (R&D). Use of Lean Sigma in pharmaceutical manufacturing is widespread and generally noncontentious. Lean Sigma is used successfully to improve the development of new pharmaceutical manufacturing processes. However, the value of the application of lean and Six Sigma ideas to research & development is controversial. Published material is reviewed, and then the methods, tools, barriers and benefits are discussed, with recommendations for implementation of Lean Sigma into an R&D organisation. 相似文献
132.
Opaque Web practices among low-cost carriers 总被引:1,自引:0,他引:1
The low-cost airlines' adoption of Web technologies to facilitate direct sales has accelerated their market penetration. However, some low-cost carriers are increasingly using Websites to create distance between themselves and their consumers in specific areas of their operations, while simultaneously developing excellence in sales transaction completion via self-service. The ‘opaque’ practices many low-cost carriers employ appear to be intentional design features and are contrary to the ethos of designing a ‘good system’ to facilitate the full spectrum of customer service. As a result, the low-cost sector has come under increased scrutiny for engaging in unfair practices and violating consumer protection law. 相似文献
133.
134.
Ann Mari May 《Feminist Economics》2013,19(4):25-37
Abstract In 2009, Elinor Ostrom received the Nobel Memorial Prize in Economic Sciences for her work, especially on governance of the commons. Trained as a political scientist, Ostrom embraced interdisciplinary research and transdisciplinary collaboration. Ann Mari May and Gale Summerfield's interview with Ostrom, conducted in fall 2011, illustrates the relevance of her work to feminist economics as well as her impressive accomplishments as the first woman recipient of the Nobel prize in economics and as a pioneering woman in academia. Ostrom died on June 12, 2012. 相似文献
135.
The Earth system is a complex adaptive system, characterised by non-linear change and with significant capacity for surprise. In times of systemic crisis, such as dangerous anthropogenic climate change, perverse resilience (for example the structural power of fossil fuel interests in the global economy) can threaten overall Earth system stability. Critical political economic analysis recognises climate change as a threat with significant political economic characteristics and implications. However, key dimensions of climate change as a globally coherent phenomenon, including the important implications of Earth system dynamism and non-linear change, can remain unrecognised, mischaracterised or underestimated. In contrast, resilience approaches describe social-ecological systems but neglect the significance of norms and power relations in human societies. This article builds theory by linking key concepts – hegemony and resilience – from neo-Gramscian political economic analysis and resilience approaches to social-ecological systems. Our objective is to generate a new conceptual framework to improve understanding of the role of politics in social-ecological systems. We use climate change and its mitigation to demonstrate the new framework's potential. 相似文献
136.
Jui-Hua Tsai Ann O. Scheimann Shawn E. McCandless Theresa V. Strong John F. P. Bridges 《Journal of medical economics》2013,16(12):1230-1237
AbstractObjectives: Prader-Willi syndrome (PWS) is a rare genetic disorder associated with varying degrees of hyperphagia, obesity, intellectual disability, and anxiety across the affected individuals’ lifetimes. This study quantified caregiver priorities for potential treatment endpoints to identify unmet needs in PWS.Methods: The authors partnered with the International Consortium to Advance Clinical Trials for PWS (PWS-CTC) and a diverse stakeholder advisory board to develop a best–worst scaling instrument. Seven relevant endpoints were assessed using a balanced incomplete block design. Caregivers were asked to determine the most and least important of a sub-set of four endpoints in each task. Caregivers were recruited nationally though patient registries, email lists, and social media. Best–worst score was calculated to determine caregiver priorities; ranging from 0 (least important) to 10 (most important). A novel kernel-smoothing approach was used to analyze caregiver endpoint priority variations with relation to age of the PWS individual.Results: In total, 457 caregivers participated in the study. Respondents were mostly parents (97%), females (83%), and Caucasian (87%) who cared for a PWS individual ranging from 4–54 years. Caregivers value treatments addressing hyperphagia (score?=?7.08, SE?=?0.17) and anxiety (score?=?6.35, SE?=?0.16) as most important. Key variations in priorities were observed across age, including treatments targeting anxiety, temper outbursts, and intellectual functions.Conclusions: This study demonstrates that caregivers prioritize hyperphagia and, using a novel method, demonstrates that this is independent of the age of the person with PWS. This is even the case for parents of young children who have yet to experience hyperphagia, indicating that these results are not subject to a hypothetical bias. 相似文献
137.
Using a unique proprietary data set of over 5400 realized and unrealized venture capital investments between 1980 and 2005, we examine the impact of demand-related factors, e.g. entrepreneurial activity, as well as supply-related factors, i.e. money provided by VC investors, on the return of individual VC investments. This way, we are able to shed more light on the question whether volatile VC investment returns are rather driven by fundamental changes with regard to the number of attractive investment opportunities or by the overreaction by investors. We find that rising demand for VC, i.e. an increase in entrepreneurial activity, results initially in higher returns. However, our results also indicate that overreaction on the supply side can be observed, destroying deal-level results. Overfunding, specifically overinvesting seems to be a recurring characteristic of the VC industry. In fact, contra-cyclical investment strategies yield highest deal-level returns. 相似文献
138.
Ersin Ancel Ann T. Shih Sharon M. Jones Mary S. Reveley James T. Luxhøj Joni K. Evans 《Journal of Risk Research》2013,16(4):428-451
This paper illustrates the development of an object-oriented Bayesian network (OOBN) to integrate the safety risks contributing to an in-flight loss-of-control aviation accident. With the creation of a probabilistic model, inferences about changes to the states of the accident shaping or causal factors can be drawn quantitatively. These predictive safety inferences derive from qualitative reasoning to conclusions based on data, assumptions, and/or premises, and enable an analyst to identify the most prominent causal factors leading to a risk factor prioritization. Such an approach facilitates a mitigation portfolio study and assessment. The model also facilitates the computation of sensitivity values based on perturbations to the estimates in the conditional probability tables. Such computations lead to identifying the most sensitive causal factors with respect to an accident probability. This approach may lead to vulnerability discovery of emerging causal factors for which mitigations do not yet exist that then informs possible future R&D efforts. To illustrate the benefits of an OOBN in a large and complex aviation accident model, the in-flight loss-of-control accident framework model is presented. 相似文献
139.
This study examines the relationship between use of international accounting standards and companies’ source of finance. We investigate the proposition contained in Nobes’ (1998) model that postulates outsider companies (those with a higher level of public finance) in weak equity–outsider markets (capital markets where public equity finance is not the dominant source of finance) are more likely to change their type of accounting system from one focused on information for creditors and tax authorities to one that meets the needs of external financiers. We found strong support for Nobes’ model. Using 408 German listed companies at 1999, we observed that companies with more outsider finance (the proportion of shares held by outsiders and the presence of public debt) were more likely to use international standards (U.S. GAAP or IAS). The results indicate the importance of controlling for source of finance at the company rather than country level in cross‐country studies investigating the benefits of adoption of international standards. 相似文献
140.
In many countries, firms can choose whether or not to report a revaluation in the financial statements. An analytical model is developed to indicate conditions in which it is more likely that successful firms will choose not to revalue assets as a credible signal to potential investors. These industry settings include a high variance in performance and low equity-to-debt ratios. The empirical results for Belgium confirm that successful firms are less likely to revalue assets in those industries. However, only the revaluation of fixed tangible assets and not financial assets seems to be a credible signal. Finally, the results support the choice to revalue, but not the amount of revaluation, as a signalling device. 相似文献