Product and process innovation in biopharmaceuticals: a new perspective on development

Developing new products and processes is increasingly a focal point of competition and often requires the development and successful implementation of novel process technologies. The process development and production of a new biological entity are significantly more complex than those for small molecule drugs. Conventional new product development models in the literature on firm level innovation fail to explain the nature of development projects for biopharmaceuticals. This paper makes the case that a new perspective is required to understand the management of product and process development in biopharmaceuticals. An explanatory model is proposed for this purpose.     

Canadian Exports of Livestock and Meat to the United States

Canadian exports of beef and live cattle to the United States have increased significantly since the late 1980s. Hog and pork exports have increased since the mid-1990s. Major factors affecting exports of beef, pork, cattle and hogs from Canada to the United States include the exchange rate, increased Canadian production, Canada-U.S. price differentials and trade liberalization under the Canada-United States Free Trade Agreement of 1989. Increased Canadian exports have resulted in small but significant reductions in U.S. domestic prices of beef, pork and hogs.     

The acceptability of different types of soymilks available in Cape Town in consumers from high and low socio‐economic areas

The aim of this study was to determine the knowledge and acceptability of soymilk (defined as consumption pattern/usage and taste) by adult consumers, residing in different socio‐economic areas (low vs. high) in Cape Town. The study population of 214 participants were selected using convenience sampling. A questionnaire was developed in order to obtain demographic data (four items); basic general knowledge of soymilk (four items); and acceptability of the tested products (consumption patterns and taste) (eight items). There was a significant difference between the two groups (P = 0.000) regarding basic knowledge of soymilk, with significantly more in the high socio‐economic area (HSEA) having a score of at least 75%. Gender (P = 0.082) and age (P = 0.122) did not have a significant impact on the consumption patterns of soymilk. There was no significant difference between the two groups with respect to current usage (P = 0.228) and frequency of use (P = 0.213) of soymilk. However, a significantly smaller group (P = 0.000) of participants in the low socio‐economic area had previously tasted soymilk compared with those in the HSEA (16.7% vs. 41.5%; P = 0.000). In conclusion, socio‐economic status appeared to be associated with knowledge of soymilk. No significant differences with regard to gender, age or current usage in the two groups studied were noted.     

Formal volunteering: a cross-national test

In this paper, we integrate disparate literatures to contribute to a better cross-national understanding of formal volunteering. We propose that three forms of capital, namely human (country wealth and country education), social (collectivism and liberal democracy) and cultural capital (religiosity) are related to formal volunteering. We use Hierarchical Linear Modeling to test our hypotheses on 38,119 individuals from 21 countries. Our results show all forms of capital (country wealth, country education, religiosity, societal collectivism and liberal democracy) have positive relationships with formal volunteering. Implications for practice and future research are discussed.     

Exercise Regions And Efficient Valuation Of American Lookback Options

This paper presents an efficient method to compute the values and early exercise boundaries of American fixed strike lookback options. The method reduces option valuation to a single optimal stopping problem for standard Brownian motion and an associated path-dependent functional, indexed by one parameter in the absence of dividends and by two parameters in the presence of a dividend rate. Numerical results obtained by this method show that, after a space-time transformation, the stopping boundaries are well approximated by certain piecewise linear functions with a few pieces, leading to fast and accurate approximations for American lookback option values. An explicit decomposition formula for American lookback options is derived and applied not only to the development of these approximations but also to the asymptotic analysis of the early exercise boundary near the expiration date.     

How Kimberly‐Clark Uses Real Options

During the past five years, Kimberly‐Clark (K‐C) has faced a familiar management challenge: How can senior managers bring the rigor and discipline used to make daily operating decisions to the uncertain and risky world of innovation? The challenge was particularly acute at K‐C because the company is well known for its reliance on Return On Invested Capital (ROIC) and Discounted Cash Flow (DCF), both measures that are widely believed to lead to undervaluation of projects with risky upside potential. This article discusses how and why K‐C adopted and now uses the real options approach to project evaluation and management. The authors also share some lessons learned during the adoption process, including how the company adapted the real options framework to its own circumstances and requirements. The K‐C experience shows that successful adoption rests on a number of factors that have less to do with the rigor or precision of quantitative models than with matters of corporate process and organizational design.     

Economics of residential crowding in developing countries

In an attempt to eliminate residential crowding, most countries pursue the policy objective of providing one dwelling unit per household. However, we know little about the demand for various dimensions of housing space which affects the levels of crowding. This paper analyzes the nature of demand for residential space and multiple occupancy in order to identify the major determinants of crowding. The result indicates that to a great extent crowding is explained by economic factors and that the current policy approach to elimination of crowding, which emphasizes one dwelling per household, is not likely to be effective.     

Long-run industry equilibrium with uncertainty

In this paper we consider the effects of uncertainty on industry equilibrium when firms must commit themselves to production before prices are revealed. We show that (a) an increase in demand uncertainty will (i) not affect the equilibrium number and size of firms if they are risk neutral, (ii) reduce the equilibrium number of firms if they are risk averse, but will have an ambiguous effect on their size. (b) In equilibrium, firms operate at capacity if they are risk neutral, but at excess capacity if they are risk averse.     

Bank-led restructuring in Poland (II): bankruptcy and its alternatives

Poland's 1993 Enterprise and Bank Restructuring Programme (EBRP) provided for the resolution of problem loans through bank-led or court-led workouts, liquidation, or loan sales. This paper examines the workings of three traditional exit processes - court-led conciliation, bankruptcy, and state enterprise liquidation. Neither bankruptcy nor court conciliation as currently designed gives creditors in Poland enough control over firsm in financial distress. Suggested improvements in design need to be complemented by strong economic policies that give banks and other creditors powerful incentives to use these debt collection mechanisms. The most problematic of the three exit routes is state enterprise liquidation, and although on paper designed for solvent firms, it is often used to get around bankruptcy and keep debtor management in control of assets for as long as possible. Now that the special bank conciliation process has expired as an option, Poland should shift its energies to improving traditional, broadly applicable exit and workout processes.