In this article we clarify mechanisms of genetic regulation of human aging and longevity traits. The objective of this article is to address the issues in previous research of not reaching a genome-wide level of statistical significance and lack of replication in the studies of independent populations. We performed GWAS of human life span using different subsets of data from the original Framingham Heart Study cohort corresponding to different quality control procedures, and we used one subset of selected genetic variants for further analyses. We used a simulation study to show that this approach to combining data improves the quality of GWAS with FHS longitudinal data to compare average age trajectories of physiological variables in carriers and noncarriers of selected genetic variants. We used a stochastic process model of human mortality and aging to investigate genetic influence on hidden biomarkers of aging and on dynamic interaction between aging and longevity. We investigated properties of genes related to selected variants and their roles in signaling and metabolic pathways and showed that the use of different quality control procedures results in different sets of genetic variants associated with life span. We selected 24 genetic variants negatively associated with life span and showed that the joint analyses of genetic data at the time of biospecimen collection and follow-up data substantially improved significance of associations of 24 selected SNPs with life span. We also showed that aging-related changes in physiological variables and in hidden biomarkers of aging differ for the groups of carriers and noncarriers of selected variants. The results of these analyses demonstrated benefits of using biodemographic models and methods in genetic association studies of these traits. Our findings showed that the absence of a large number of genetic variants with deleterious effects may make substantial contribution to exceptional longevity. These effects are dynamically mediated by a number of physiological variables and hidden biomarkers of aging. The results of these research demonstrated benefits of using integrative statistical models of mortality risks in genetic studies of human aging and longevity. 相似文献
As researchers pursue connections between strategic communication and management, they need to critique practices to develop norms that increase strategic communication’s long-term contribution to society. Norms of strategic communication are shaped by socially constructed standards of corporate social responsibility (CSR) and guide how strategic communication fosters organization-public relationships (OPR). Such norms are particularly important regarding deliberative strategic communication, which uses political CSR to guide corporations’ political role. Although principles of OPR and political CSR should foster more ethical strategic communication, some practices weaken such standards. To make that case, this article (1) reviews the historical foundations of deliberative discourse, (2) examines principles of OPR and political CSR, and (3) applies normative principles of deliberative discourse (4) to critique three cases of strategic political communication, known as astroturf lobbying, a deceptive lobbying practice that undermines and fakes grassroots movements. We conclude by integrating the findings into theory building that shifts CSR outcomes from advantaging individual organizations adding value to society. This theme uses ‘creating shared value’ to advocate shared strategic communication. This notion includes the normative claims of political CSR (open discourse, participation, transparency, accountability) to arrive at shared strategic communication that supports the ‘good’ organization and society simultaneously. 相似文献
Development of the modern global entrepreneurship is one of the most perspective and promising means of overcoming the consequences of the global economic crisis, as well as prevention of future crises of economic systems, as it ensures full level of optimization of production and distribution processes. The purpose of the article is to determine perspectives of sustainable development of the global entrepreneurship. For determining the level of sustainability of development of the modern global entrepreneurship, the authors use the methods of statistical analysis of time rows (method of horizontal and trend analysis). The authors perform a complex analysis of dynamics of development of global companies and performed evaluation of their sustainability. Also, the necessity for changing the model of managing the development of modern global entrepreneurship for increasing its sustainability is substantiated. As a result, it is concluded that modern global entrepreneurship is developing in the unstable way, and practical recommendations are offered for solving this problem. A perspective model of sustainable development of the modern global entrepreneurship is developed and presented. A certain limitation of the results of the performed research is the framework character of the offered recommendations.
We provide a set of conditions sufficient for consistency of a general class of fixed effects instrumental variables (FE-IV) estimators in the context of a correlated random coefficient panel data model, where one ignores the presence of individual-specific slopes. We discuss cases where the assumptions are met and violated. Monte Carlo simulations verify that the FE-IV estimator of the population averaged effect performs notably better than other standard estimators, provided a full set of period dummies is included. We also propose a simple test of selection bias in unbalanced panels when we suspect the slopes may vary by individual. 相似文献
In this paper, we provide theory and evidence on the problem of corruption in the Russian Federation. Our theoretical model indicates that in the presence of official corruption, the numbers of tax inspection (collection) employees could be inversely related to per capita tax collection. Our empirical analysis supports our theoretical model, shedding light on one of the most intractable problems in the Russian Federation. 相似文献
The paper discusses several reliability measures: Scott’s pi, Krippendorff’s alpha, free marginal adjustment (Bennett, Alpert and Goldstein’s \(S\)), Cohen’s kappa, and Perreault and Leigh’s \(I\) and the assumptions on which they are based. It is suggested that correlation coefficients between, on one hand, the distribution of qualitative codes and, on the other hand, word co-occurrences and the distribution of the categories identified with the help of the dictionary based on substitution complement the other reliability measures. The paper shows that the choice of the reliability measure depends on the format of the text (stylistic versus rhetorical) and the type of reading (comprehension versus interpretation). Namely, Cohen’s kappa and Bennett, Alpert and Goldstein’s \(S\) emerge as reliability measures particularly suited for perspectival reading of rhetorical texts. Outcomes of the content analysis of 57 texts performed by four coders with the help of computer program QDA Miner inform the analysis. 相似文献
This study explored some human resource and human systems' aspects of the competitive dynamics for firms attempting to survive and prosper within Russia, a highly volatile transition economy. Overall, this study adds to our understanding of international strategic human resource management, dynamic capabilities, and the generation of competitive advantage within transition economies. We found that a relatively new construct derived from the dynamic capabilities and organizational change literatures, known as ‘organizational capacity for change,’ is positively associated with firm performance within a wide variety of Russian firms. Furthermore, we find that the relationship between organizational capacity for change and firm performance is stronger when there are relatively high levels of uncertainty with the task environment. Finally, we found that organizational capacity for change is an important attribute in all sizes of organizations, not just for large organizations as hypothesized. 相似文献