The paper investigates implications of different theoretical models for hierarchical structure. A sample of 6,578 firms in
the Brazilian manufacturing industry is considered and explanatory factors pertaining to structural characteristics, network
technology, technological innovations, managerial innovations and incentive mechanisms are investigated. Important joint effects
are detected for all groups of variables in partial contrast with the related previous literature. Moreover, one detects significant
joint effect of the newly considered group of incentive variables. The evidence in terms of individual effects is largely
consistent with the predicted effects from the theoretical literature. 相似文献
Background: A 3-month long treatment of paliperidone palmitate (PP3M) has been introduced as an option for treating schizophrenia. Its cost-effectiveness in Spain has not been established.
Aims: To compare the costs and effects of PP3M compared with once-monthly paliperidone (PP1M) from the payer perspective in Spain.
Methods: This study used the recently published trial by Savitz et al. as a core model over 1 year. Additional data were derived from the literature. Costs in 2016 Euros were obtained from official lists and utilities from Osborne et al. The authors conducted both cost-utility and cost-effectiveness analyses. For the former, the incremental cost per quality-adjusted life-year (QALY) gained was calculated. For the latter, the outcomes were relapses and hospitalizations avoided. To assure the robustness of the analyses, a series of 1-way and probability sensitivity analyses were conducted.
Results: The expected cost was lower with PP3M (4,780€) compared with PP1M (5,244€). PP3M had the fewest relapses (0.080 vs 0.161), hospitalizations (0.034 v.s 0.065), and emergency room visits (0.045 v.s 0.096) and the most QALYs (0.677 v.s 0.625). In both cost-effectiveness and cost-utility analyses, PP3M dominated PP1M. Sensitivity analyses confirmed base case findings. For the primary analysis (cost-utility), PP3M dominated PP1M in 46.9% of 10,000 simulations and was cost-effective at a threshold of 30,000€/QALY gained.
Conclusions: PP3M dominated PP1M in all analyses and was, therefore, cost-effective for treating chronic relapsing schizophrenia in Spain. For patients who require long-acting therapy, PP3M appears to be a good alternative anti-psychotic treatment. 相似文献
Training professionals for the new 21st century requires universities to make major changes in their conception of teaching,
which, through the active, committed participation of teachers and students, will lead to the building and developing of the
competencies needed by students for them to perform efficiently, ethically and with social commitment in their future jobs.
The participation of teachers and students and their commitment to quality in the teacher training process are essential elements
in the search for alternative ways to enhance university teaching. This article discusses the teacher training experiences
had by the author in the ICE of Madrid Polytechnic University with the inclusion of data from a study undertaken on the Environmental
Sciences course of this university where teachers, students and postgraduates’ perception of the quality of their vocational
training at university is an important starting point for the design of strategies aimed at enhancing the quality of teaching. 相似文献
Perception of safety is an important factor affecting the leisure behavior of Latinos residing in urban neighborhoods. Yet research on how fear of crime and fear of gangs in particular affect leisure of ethnic and racial minorities is underdeveloped. The objectives of this study are to examine how gangs operate in recreation spaces in Latino neighborhoods, how gangs affect the use of outdoor recreation environments and how Latinos respond to these issues. The study is based on focus groups conducted with Latino residents in Chicago. Findings indicate gang members are almost constantly present in parks, which serve as spaces for drug use and distribution. Moreover, gangs operate in other areas of the neighborhood making it unsafe to access parks. Participants employ strategies to address the gang problem including avoidance, protective and collective behaviors. 相似文献
AbstractThe relationship between tourism and climate change is reciprocal. The effects of climate change on tourism are undeniable. However, tourism and climate change are complex and cross-cutting phenomena that enter policy agendas at different moments and with different discourses. This paper analyses the coherence between the policy domains of climate and tourism at the formulation stage of the policy process, focusing on national and regional government levels and the key touristic offer in Spain – that of sun, sea and sand. The proposed method analyses three dimensions within policy documents: frame significance, policy scope and connotation. Results reveal the imbalance between the two policy domains; the lack of concrete actions and stable mechanisms for achieving greater coherence; and the different conceptions of the issue. The paper considers the causal relationships between tourism and climate change, the consequences of mutual impacts, and the temporal dimension of problem framing. This research brings together three fields of knowledge – tourism, climate change and public policies – and suggests enhancing coherence between tourism and climate policies in order to address the sustainability of tourism destinations. 相似文献
In the past decade, tourism firms have become aware of the great benefits of maintaining a solid base of loyal customers. Because rural tourism is a relatively new phenomenon in some countries, the main antecedent of tourism loyalty remains infrequently studied in rural lodgings. In this work, a structural equations model is explored, with PLS technique, giving relevance to the interrelationships among image, quality, satisfaction, and trust and among these variables and the tourists' behavior variables. Instruments are identified and exploratory research was undertaken among rural tourists of the main rural lodgings in two border regions of Spain and Portugal. The results confirm image as a direct antecedent of perceived quality, satisfaction, trust, and loyalty for rural tourism, too. The analysis also confirmed that quality has a positive influence on satisfaction and loyalty, and trust has a positive influence on loyalty. Image is shown as a key factor to rural lodging managers. This study may help rural tourism managers to develop and implement effective relationship marketing strategies. 相似文献