Gene-environment interactions and the complexity of human genetic diseases

In the assessment of mortality and morbidity risk, the ability of family history and genetic test results to predict the age of occurrence, severity, and long-term prognosis of 'genetic' diseases is important. An increasing number of gene-gene and gene-environment interactions have been demonstrated in a number of monogenic Mendelian diseases. These interactions can significantly modify the clinical presentation (disease phenotype) of diseases previously regarded purely as 'genetic.' As a result, 'genetic' diseases can be positioned in a continuum between classic Mendelian and complex disease where the extremes, pure genetic or solely non-genetic, do not exist. The position of any given disease in this continuum is defined by three components: the major gene(s) contributing to the phenotype, the variability added by modifier genes and the significance of environmental factors influencing the phenotype. As the predictive value of genetic test results can be significantly influenced by additional genetic and environmental risk factors, a better understanding of these factors may influence the quantification of mortality and morbidity risk.     

Development strategy for rural areas

In September 1973, the President of the World Bank, Robert S. McNamara, made a challenging address to the Governors of the Central Banks of the member states of the international Monetary Fund. The main subject in his speech was the problem of poverty particularly in rural areas of developing countries, and the design for a strategy for its abolition.     

Food in sub-Saharan Africa : Trends and policy challenges for the 1990s

The food situation in Africa can be expected to become increasingly serious as the end of the century approaches. The gap between domestic supply and food needs in rapidly widening. Yield-increasing technology becomes essential in view of land scarcity in high-potential areas and sustainability problems in marginal zones. The concern of governments for food self-sufficiency, however, must not divert attention from the primary objective of household food security, which is essentially a question of households' real income. Accelerated rural growth and improved rural health and sanitation services accessible to the poor are central elements for household food security improvement.     

Structural transformation in China and India: A note on macroeconomic policies

This paper explores macroeconomic policies that can sustain structural change in China and India. A two-sector open-economy model with endogenous productivity growth, demand driven output and income distribution as an important determinant of economic activity is calibrated to a 2000 SAM for China and a 1999/2000 SAM for India. Short-run analysis concerns temporary equilibria for output, productivity and employment growth rates in the formal sector. In the long-run, the model allows for multiple equilibria which can describe cases of (a) underdevelopment and structural heterogeneity or (b) sustained growth and development. Several simulation exercises are conducted. Specifically, we consider how changes in investment, wages, labor productivity trend and a depreciation of currency affect the macroeconomy and job creation in the formal sector.     

Enlarging the EU: How can the costs be minimised?

Enlargement of the EU will be associated with many costs for all participants— the prospective new members, the old memebers and the EU institutions. A strategy should be pursued that reduces the economic costs as far as possible. This implies a postponement of enlargement until the conditions are more favourable. The author would like to thank Prof. El-Shagi El-Shagi and Dr. Dorothea Witter-Rieder for helful comments on an earlier draft of this paper.