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921.
    
The present study seeks to shed further light on what favors the conversion of inventions into innovations in for-profit firms and to advance our understanding of how to tackle cancer grand challenges (CGCs). Specifically, following the literature on knowledge search and recombination, we analyze whether and how cancer-related inventions developed through an intense adoption of scientific knowledge (scientific search intensity) result in (i) a higher number of approved drugs and (ii) a shorter approval time for new drugs. Notably, while the role of science with regard to technological development has been widely studied, the extent to which science-based solutions relate to new product introduction, especially in terms of coping with grand challenges such as approved cancer drugs, is less known. Furthermore, considering the digitization of (health) R&D and the role of information and communication technologies (i.e., digital technologies) to address grand challenges, we examine whether and how cancer-related inventions developed through an intense adoption of digital knowledge (digital search intensity) directly affect the extent and speed of cancer drug approval, as well as whether interaction effects between scientific and digital search intensity exist. We develop hypotheses that we test on a sample of 65,861 cancer-related patents owned by 139 for-profit firms, collected from the USPTO Cancer Moonshot Patent Data. These have a priority date between 1990 and 2010, and have led to 1035 approved drugs. Results reveal that scientific search intensity is not associated with the number of different drugs developed from a single cancer-related invention but is associated with the speed at which the invention leads to a newly approved drug. Digital search intensity appears not to directly affect cancer drug approval, but it lessens the effects of scientific search intensity, thus pointing to a limit of digitization in cancer R&D and innovation processes.  相似文献   
922.
The new economy is a technological revolution involving the information and communication technologies and which affects almost all aspects of the economy, business, and our personal lives. The problems it raises for businesses are not radically new, and even less so from an ethical viewpoint. However, they deserve particular attention, especially now, in the first years of the 21st century, when we are feeling the full impact of the changes brought about by this technological revolution. In this article, I will try to draw a "map" of the main, positive and negative ethical challenges raised by the new economy, concentrating on its three basic features: (1) a knowledge- and information-based technological change, (2) which is taking place in real time on a planetary scale (globalization), and (3) which entails a new, flexible, network-based business organization.  相似文献   
923.
    
Paying Indigenous communities to conserve land for carbon sequestration is a controversial way of tackling climate change. Critics argue that paying for ecological services (or ‘PES’) in the form of carbon offset programmes reduces land and social relations to an economic transaction that devalues Indigenous livelihoods and communities. At the same time, empirical studies have shown that Indigenous communities have accepted and even embraced the idea of being paid to conserve land for climate change mitigation. This paper explores this apparent contradiction by investigating the implementation of Programa Socio Bosque (PSB), a PES carbon sequestration programme in Ecuador. Drawing upon primary fieldwork in the highland province of Chimborazo, it makes the case that PES programmes need to be understood as form of state power that reconfigures and reinforces the ways in which Indigenous peoples engage with the state. Particularly important in this regard is the role of the state in reinforcing the agrarian conditions under which Indigenous communities use and interpret PES payments while at the same time reconfiguring new forms of land conservation. Empirically, the research reveals important complementarities between the goals of carbon sequestration PES programmes and Indigenous land-use practices. Methodologically, it highlights the importance of situating the study of PES programmes in a context of land struggles, community–state relations and agrarian change.  相似文献   
924.
Based on the careful observation and interviews of employees at three companies, and supplemented by cases from the popular business press, a discovery approach is used to derive four management principles that engender creativity and innovation in organizations: (1) manage organizations so that their knowledge base is more diverse than what would occur naturally; (2) encourage employees to embrace a collaborative and non-complacent attitude towards work and the organization; (3) make it possible for organization members to engage in the quick testing of ideas and solutions as they emerge; (4) reward employee and supervisor behaviors that support these principles and punish resistance to their implementation. The principles work in companies even if creativity and innovation are not stated organizational objectives, and do not require large investments or disruptions to work processes to yield valuable results.  相似文献   
925.
To build profitable market positions, new ventures have to address multiple challenges on several fronts. These ventures can compete by being simple (focused) or applying varied ways to compete. The likelihood of these ventures remaining competitive depends on their ability to build novelty into their products and operations, an activity that requires infusing knowledge into their operations. Most ventures, however, have limited knowledge bases and the reach (scope) of their external connections is limited, a factor that prompts them to tap into different external sources in their local areas. This article reports an empirical study of 140 new ventures located in seven regional clusters in Spain. The results show that new ventures can enrich the variety of their strategic repertoire by accessing diverse sources of external knowledge and being exposed to external novel knowledge, while absorptive capacity moderates this relationship. The degree of social development of these clusters also has a positive impact on the strategic variety of new ventures, exhibiting an inverted U-shape curve.  相似文献   
926.
This article establishes an extended set of risk neutral valuation relationships (RNVR's), assuming a representative agent who has an extended power utility function, of the HARA class of utility functions. The utility function of the representative agent displays either increasing, constant or decreasing proportional risk aversion. Aggregate consumption and the random payoff of the underlying asset are bivariate three-parameter lognormal distributed. As an application of the RNVR's, closed-form solutions for the price of a call written on a stock are derived. These include an extra parameter, the threshold parameter, not contained in the Black-Scholes formula.  相似文献   
927.
    
We apply a value chain approach to examine how blackberry producers in Ecuador can improve production and marketing practices to obtain more favorable prices. Results show that general upgrading actions are associated with improved producer prices, and specific activities, such as seeking information from reputable sources can lead to substantial welfare improvements. The paper goes beyond most value chain studies which treat participation in a ‘modern’ value chain as a discrete state. Ecuador's blackberry industry is evolving incrementally with no clearly discernible ‘modern’ market chains. Instead, producers incrementally make improvements in multiple dimensions. Relatively low‐cost practices, many of which do not imply substantial risk or investment, are associated with price improvements. Obstacles to participation in incremental value chain upgrading activities are not insurmountable. In particular, scale of production is not a limiting factor: small‐scale producers are not precluded from adopting improved practices and they do not suffer in terms of price received.  相似文献   
928.
    
Institutionalist explanations of the high non‐standard employment rate in the Spanish labour market have pointed to the relevance of flexibilization at the margin, that is, the deregulation of non‐standard jobs. Using Spanish social security micro data, we find evidence that the liberalization reforms of 2010 and 2012 had flexibilization at their core, that is, greater instability due to open‐ended and full‐time contracts (erosion of employment protection) and a rise in turnover among periphery workers, increasing the segregation gap. We conclude that there is a high level of deregulation and simultaneous dualization due to the combination of flexibilization at the margin (until 2008) and the core (2010–2012).  相似文献   
929.
    
This paper analyses how universities leverage knowledge coming from different technological, institutional, and geographical domains to develop technologies exerting a relevant impact for firms’ technological advancements. The analysis is based on a panel of 219 worldwide universities that filed, at least, a patent belonging to the alternative energy production sector in the period 2002–2010. Results show that using external knowledge originating in different technological and institutional domains exerts an inverted U‐shaped effect on the firms’ subsequent technological progress, while the geographical origin seems to do not exert any influence.  相似文献   
930.
    
Los autores dan cuenta de una investigación sobre los perfiles personales y académicos de hombres y mujeres con responsabilidades directivas en empresas españolas, su situación profesional y su postura respecto a la igualdad de género. Las directivas españolas son más jóvenes que sus homólogos masculinos, pero los alcanzan o superan en cualificación profesional y tienen menos hijos que ellos. Sin embargo, siguen luchando contra las barreras que impiden el aprovechamiento pleno del enorme capital humano femenino. A pesar de las medidas tomadas, más de nueve de cada diez puestos directivos siguen ocupados por hombres.  相似文献   
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