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81.
AbstractAims: Among patients diagnosed with prostate cancer, 10–20% will develop castration-resistant prostate cancer (CRPC) within 5?years; for 70%, CRPC will metastasize, mostly to the lungs and/or liver. We performed a cost-effectiveness model comparing abiraterone plus prednisone (ABI?+?PRD), cabazitaxel plus prednisone (CAB?+?PRD) and enzalutamide (ENZ) for visceral metastatic CRPC post-docetaxel therapy resistance.Methods: A three-state (Progression-Free, Progression, Death) lifetime Markov model was constructed to compare ABI?+?PRD, CAB?+?PRD, and ENZ from a United States healthcare payer perspective (2019?US$; discount rate 3%/yr.). Effectiveness was measured in life-years (LYs) and quality-adjusted life years (QALYs). Inputs included treatment costs, grade III/IV adverse events with incidence ≥5%, physician follow-up, lab and imaging tests. Phase III trial Kaplan-Meier curves were extrapolated to estimate overall survival and Progression-Free transition probabilities. Incremental cost-effectiveness ratios (ICERs) and utility ratios (ICURs), probabilistic sensitivity analyses (PSAs) and cost-effectiveness acceptability curves at willingness-to-pay (WTP) thresholds were estimated.Results: Models estimated 3-year overall survival rates of 1.3% for patients treated with ABI?+?PRD, 16.2% for CAB?+?PRD, and 13.2% for ENZ. Estimated Progression-Free rates at 1.5?years were 0.51% for ABI?+?PRD, 0.27% for CAB?+?PRD, and 14.47% for ENZ. LYs and QALYs were 1.20 and 0.58 respectively for ABI?+?PRD, 1.48 and 0.56 for CAB?+?PRD, and 1.58 and 0.79 for ENZ. Total treatment costs were: $115,433 for ABI?+?PRD, $85,337 for CAB?+?PRD and $109,213 for ENZ. CAB?+?PRD and ENZ dominated ABI?+?PRD due to higher LYs gained. Incremental QALYs for ENZ vs. CAB?+?PRD were larger than incremental LYs. The ICUR for ENZ was $103,674/QALY compared to CAB?+?PRD.Conclusions: This analysis found ENZ provided greater LYs and QALYs than both ABI?+?PRD and CAB?+?PRD, at a lower cost than ABI?+?PRD, but at a higher cost compared to CAB?+?PRD. For patients with visceral mCRPC after docetaxel therapy resistance, ENZ was cost-effective 92% of the time with a WTP threshold of $100,000/QALY. 相似文献
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83.
This article contributes to the literature on board effectiveness by being perhaps the first to systematically examine how the nature of outside directors' prior experience, and resulting expertise, will influence the performance of a focal firm's strategic initiatives. Our theoretical model is grounded in the psychological literature on expertise and its role in group decision making effectiveness. We focus on outside director expertise in acquisition decision making, and its implications for the performance of the acquisitions of a focal firm. Our conceptual framework indicates that directors will develop expertise in making particular kinds of acquisition decisions (e.g., related or unrelated acquisitions or acquisitions in specific industries or product markets) through their past experiences at other firms with decisions about those specific types of acquisitions, and we predict that this experience and expertise will have positive effects on the performance of a focal firm's acquisitions. We extend our theoretical model to consider the conditions under which relevant director experience will prove most beneficial. Our model predicts that outside director acquisition expertise will deliver the greatest benefits when the focal firm's board is independent from management. We find empirical support for all of our hypotheses. In considering how and when director experience and resulting expertise may influence the performance of corporate acquisitions, our theory and results help to highlight a potential second main focus for research on the long‐standing question of what factors render boards of directors effective. Copyright © 2008 John Wiley & Sons, Ltd. 相似文献
84.
Melissa L. Finucane Michael J. Blum Rajeev Ramchand Andrew M. Parker Shanthi Nataraj Noreen Clancy 《Journal of Risk Research》2020,23(1):1-10
AbstractResearch and practice aimed at enhancing community resilience to disasters such as hurricanes have focused primarily on the survival of individuals and the development of social capital and networks. Less consideration has been given to the dynamics of social-ecological conditions that can govern post-disaster outcomes. This article provides a rationale for moving research and practice towards an adaptive systems framework, drawing on the cascading challenges that Gulf of Mexico coastal communities have endured since the 2010 Deepwater Horizon (DWH) oil spill. The adaptive approach recognizes that, in some situations, crises can highlight avenues for improvement, where greater resilience can be achieved by addressing the dynamic context of a disaster. We discuss implications for clarifying interdependencies, bridging the science-society gap, and making course corrections through iterative processes. We also highlight how the approach might foster policy addressing global challenges such as changing climate conditions, rapid urbanization, and disease pandemics. 相似文献
85.
Gary Blau Greg Gibson Melissa Bentley Susan Chapman 《International Journal of Training and Development》2012,16(1):54-66
We tested the incremental impact of a job‐related set of variables for explaining a utility judgment training effectiveness variable, that is, course completion skill preparedness, beyond background and course‐related variables. Our respondents were two different emergency medical service samples, 415 basics and 742 paramedics, from the 2008 US Longitudinal Emergency Medical Technician Attributes and Demographic Study. Extending earlier research into the training of US emergency medical services staff, we developed scales for measuring two course‐related affective reaction variables, quality of course materials and quality of lead instructor. We found for both samples that the quality of course materials and quality of lead instructor variables each significantly explained course completion skill preparedness variance beyond controlled‐for background variables. We also found that the set of job‐related variables explained further, additional variance and that job satisfaction was positively related to course completion skill preparedness for both samples. The limitations of the study and future research ideas are discussed. 相似文献
86.
Journal of Business Ethics - Explanations of organizational misconduct frequently point to declining firm performance and/or the actions of unethical or suspect leaders. Evidence that... 相似文献
87.
AbstractKuwait offers a powerful context for investigating the entrepreneurial cultures developing in Gulf countries in response to the concurrent trends of pursuing economic diversification and efficiency, and the constraints posed by cultural narratives that maintain inequality between the sexes. Bringing a capabilities lens to the analysis of entrepreneurship promotion programs means shifting from a focus on meeting basic human needs to ensuring capabilities development. To begin, we discuss the capabilities approach to entrepreneurship with a focus on the necessity/opportunity classification. Next, we review the entrepreneurship ecosystem in Kuwait, including its focus on opportunity entrepreneurs and the legal, economic, and sociocultural framework in which they operate. After considering the impact of Kuwait’s gender-blind approach on women’s entrepreneurship, we conclude with some suggestions for strengthening Kuwait’s potential for capability expansion through entrepreneurship. 相似文献
88.
The current paper addresses three important yet generally overlooked issues regarding the conceptualization and measurement of counterproductive work behaviors (CWBs). First, we argue that the field would benefit from the adoption of situation-specific CWB measures that are tailored to the organization or occupation being studied. Such an approach would ensure that CWB measures include sample-relevant behaviors and exclude irrelevant behaviors. Second, we discuss several potential sub-dimensions of CWBs that should be examined in future research. These sub-dimensions include: 1) legal vs. illegal activities, 2) hostile vs. instrumental aggression, and 3) task-related vs. non-task-related counterproductive behaviors. Finally, we consider the relevance of the bandwidth-fidelity principle to the measurement of CWBs. 相似文献
89.
We examine earnings management around the annual general meeting (AGM) and assess the influence of managerial entrenchment. Consistent with prior research, we show positive and statistically significant abnormal returns surrounding AGMs regardless of the level of managerial entrenchment. We find evidence of significant earnings manipulation primarily among entrenched managers. Specifically, they manage abnormal accruals downward two quarters prior to the AGM and significantly increase abnormal accruals in the quarter immediately before the AGM. Our evidence is consistent with AGMs triggering managers to disseminate information in a manner that shapes the market's perception of the firm. 相似文献
90.
This study explores the role of short sale constraints in explaining the variation in premiums to Net Asset Value (NAV) in REIT pricing. We use proprietary information on short sales between June 2006 and September 2008 to examine how short sales and short sale constraints affect the variation in monthly REIT NAV premiums using panel vector autoregression models. We find that variation in short sale activity across individual REITs can account for at least one‐third of the variation in NAV premiums. Short sale constraints tend to be binding when there is strong demand and limited supply of shares to short. Excess demand leads to overvaluation and the correction of the overvaluation explains the under‐performance of premium REITs. 相似文献