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Daniel Yekutieli Anat Reiner-Benaim Yoav Benjamini Gregory I. Elmer Neri Kafkafi Noah E. Letwin Norman H. Lee 《Statistica Neerlandica》2006,60(4):414-437
The multiplicity problem is evident in the simplest form of statistical analysis of gene expression data – the identification of differentially expressed genes. In more complex analysis, the problem is compounded by the multiplicity of hypotheses per gene. Thus, in some cases, it may be necessary to consider testing millions of hypotheses. We present three general approaches for addressing multiplicity in large research problems. (a) Use the scalability of false discovery rate (FDR) controlling procedures; (b) apply FDR-controlling procedures to a selected subset of hypotheses; (c) apply hierarchical FDR-controlling procedures. We also offer a general framework for ensuring reproducible results in complex research, where a researcher faces more than just one large research problem. We demonstrate these approaches by analyzing the results of a complex experiment involving the study of gene expression levels in different brain regions across multiple mouse strains. 相似文献
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Noah Williams 《Journal of Economic Theory》2004,119(2):271-298
We develop analytic asymptotic methods to characterize time-series properties of nonlinear dynamic stochastic models. We focus on a stochastic growth model which is representative of the models underlying much of modern macroeconomics. Taking limits as the stochastic shocks become small, we derive a functional central limit theorem, a large deviation principle, and a moderate deviation principle. These allow us to calculate analytically the asymptotic distribution of the capital stock, and to obtain bounds on the probability that the log of the capital stock will differ from its deterministic steady-state level by a given amount. This latter result can be applied to characterize the probability and frequency of large business cycles. We then illustrate our theoretical results through some simulations. We find that our results do a good job of characterizing the model economy, both in terms of its average behavior and its occasional large cyclical fluctuations. 相似文献
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As a financial executive, are you a Business answer will determine how successful you will be in tomorrow's digital economy. © 2000 John Wiley & Sons, Inc. 相似文献
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We present several new characterizations of correlated equilibria in games with continuous utility functions. These have the advantage of being more computationally and analytically tractable than the standard definition in terms of departure functions. We use these characterizations to construct effective algorithms for approximating a single correlated equilibrium or the entire set of correlated equilibria of a game with polynomial utility functions. 相似文献
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Noah Shepherd 《旅游业当前问题》2013,16(3-4):309-318
In 1989, two ecotourism operators started business in South Thailand – SeaCanoe, running kayaking trips in Phang Nga Bay, and Siam Safari, running nature tours in Phuket and South Thailand. Both companies have received international awards and recognition for their work in promoting environmentally sensitive tours yet their efforts seem to have been thwarted by the growth in mass tourism within South Thailand. Throughout the 1990s, Phuket received a three-fold increase in arrivals, and with it the establishment of many imitators of the original pioneers. This paper looks at the relationship between mass tourism and ecotourism and questions whether the two are compatible or mutually exclusive. 相似文献
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Research on informal housing tends to focus overwhelmingly on less developed countries, downplaying or ignoring entirely the presence of informality in United States housing markets. In actuality, a longstanding and widespread tradition of informal housing exists in the United States but is typically disregarded by scholars. In this article we draw on three definitions of informality—as non‐compliant, non‐enforced, or deregulated economic activity—to characterize examples of informality in US housing markets, focusing in particular on five institutions that govern housing market activity in this country: property rights law, property transfer law, land‐use and zoning, subdivision regulations, and building codes. The cases presented here challenge the notion that informality is absent from US housing markets and highlight the unique nature of informal housing, US style—namely, that informal housing in the US is geographically uneven, largely hidden and typically interwoven within formal markets. We conclude with a discussion of how research on informal housing in the US can inform research in the global South. 相似文献
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